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Integration of knowledge and biobank resources in comprehensive translational approach for personalized prevention and treatment of metabolic disorders

Total Cost €


EC-Contrib. €






Project "INTEGROMED" data sheet

The following table provides information about the project.


Organization address
city: RIGA
postcode: 1067

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Latvia [LV]
 Total cost 800˙000 €
 EC max contribution 800˙000 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-WIDESPREAD-2018-03
 Funding Scheme CSA
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2022-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    LUNDS UNIVERSITET SE (LUND) participant 150˙000.00
3    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 150˙000.00
4    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 150˙000.00


 Project objective

INTEGROMED is aiming to provide LBMC with the opportunity to integrate the experience of research excellence institutions and existing resources by creating a research and innovation network with three internationally leading organizations in the translational medicine area – University of Dundee, Lund University, and Weizmann Institute of Science. The strategy of INTEGROMED is to increase excellence and develop sustainable approach targeting virtually all aspects of translational medicine including the optimal use of clinical and biobank resources, integration of different omics in systemic workflow, reaching development of bedside applications and fostering entrepreneurism. Project has a strong focus on study of metabolic disorders including type 2 diabetes, however the training, mentoring and stuff exchange activities as well as practical outcomes will be available for other fields including researchers, clinicians and other stakeholders in Latvia, promoting the implementation of the developed strategies at larger scale. The result of project will be accomplished by following three main objectives. (1) To improve and optimize the use of resources provided by large biobanks and prospective cohorts in combination with national health care system, improve knowledge in establishment of clinical studies for development of precision medicine approaches. (2) To strengthen collaboration-based training of specialists in areas of multi-omics approaches, bioinformatics, and modelling to increase excellence in implementing cutting edge multi omics technologies in such areas as genomics, methylation and expression profile, microbiome and metabolome analysis. (3) To elaborate a long-term strategy and sustainability plan involving all relevant stakeholders, ensure development and training in clinical applications and entrepreneurial skills to build an innovation ecosystem around LBMC.


year authors and title journal last update
List of publications.
2018 Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth, Janis Klovins
Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals
published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-018-0593-x
Clinical Epigenetics 10/1 2019-12-16
2019 Dita Gudra, Saeed Shoaie, Davids Fridmanis, Janis Klovins, Hugo Wefer, Ivars Silamikelis, Raitis Peculis, Ineta Kalnina, Ilze Elbere, Ilze Radovica-Spalvina, Rolf Hultcrantz, Ģirts Šķenders, Marcis Leja, Lars Engstrand
A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies
published pages: 1723-1725, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-316225
Gut 68/9 2019-12-16
2018 Mikhail Baryshev, Inna Inashkina, Kristine Salmina, Anda Huna, Thomas R Jackson, Jekaterina Erenpreisa
DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells
published pages: 362-366, ISSN: 1538-4101, DOI: 10.1080/15384101.2018.1426412
Cell Cycle 17/3 2019-12-16
2016 Linda Zaharenko, Ineta Kalnina, Kristine Geldnere, Ilze Konrade, Solveiga Grinberga, Jozef Židzik, Martin Javorský, Aivars Lejnieks, Liene Nikitina-Zake, Davids Fridmanis, Raitis Peculis, Ilze Radovica-Spalvina, Dace Hartmane, Osvalds Pugovics, Ivan Tkáč, Lucia Klimčáková, Valdis Pīrāgs, Janis Klovins
Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients
published pages: 531-540, ISSN: 0804-4643, DOI: 10.1530/eje-16-0347
European Journal of Endocrinology 175/6 2019-12-16
2018 Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Kristine Sekace, Ilze Radovica-Spalvina, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins
Association of metformin administration with gut microbiome dysbiosis in healthy volunteers
published pages: e0204317, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0204317
PLOS ONE 13/9 2019-12-16
2018 Vita Rovite, Yael Wolff-Sagi, Linda Zaharenko, Liene Nikitina-Zake, Elmars Grens, Janis Klovins
Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results
published pages: 353-360, ISSN: 0917-5040, DOI: 10.2188/jea.je20170079
Journal of Epidemiology 28/8 2019-12-16
2019 Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovins
Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals
published pages: e0224835, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0224835
PLOS ONE 14/11 2019-12-16

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