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ENHPATHY SIGNED

Molecular basis of human enhanceropathies

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "ENHPATHY" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 3˙992˙397 €
 EC max contribution 3˙992˙397 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 274˙802.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 297˙522.00
3    SYDDANSK UNIVERSITET DK (ODENSE M) participant 297˙522.00
4    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) participant 281˙982.00
5    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 281˙276.00
6    ADVANCED BIODESIGN FR (SAINT-PRIEST) participant 274˙802.00
7    ELVESYS FR (PARIS) participant 274˙802.00
8    GEN-X BV NL (AMSTERDAM) participant 265˙619.00
9    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) participant 265˙619.00
10    HUMANITAS UNIVERSITY IT (PIEVE EMANUELE) participant 261˙499.00
11    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 252˙788.00
12    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) participant 250˙904.00
13    UNIVERSIDAD DE CANTABRIA ES (SANTANDER) participant 250˙904.00
14    USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE CZ (PRAHA 4) participant 234˙871.00
15    UNIWERSYTET WARSZAWSKI PL (WARSZAWA) participant 227˙478.00

Map

 Project objective

Mutations within coding genes have traditionally been considered the major genetic cause of human disease. However, it is becoming increasingly clear that the genetic, structural and/or epigenetic disruption of enhancers and enhancer landscapes represent major etiological factors in numerous human diseases (i.e. enhanceropathies), ranging from rare congenital disorders to common diseases associated with ageing (e.g. cancer, diabetes). Although changes in enhancer activity are predicted to have broad pathological and therapeutic implications, we currently have a limited mechanistic understanding of human enhanceropathies. This reflects, at least partly, our still primitive and partial understanding of the mechanisms whereby enhancers can control gene expression. We hypothesize that enhancers are a diverse group of regulatory sequences that can utilize different mechanisms to control gene expression at the transcriptional and/or post-transcriptional level. Consequently, human enhanceropathies are likely to display an equally diverse molecular basis that, we believe, can only be uncovered using highly multidisciplinary systems biology approaches. Chiefly, elucidating the molecular basis of human enhanceropathies has far reaching translational implications, especially considering the pandemic proportions that some of these disorders are acquiring in recent years. Therefore, the major goal of the ENHPATHY network is to provide early-stage researchers with a multidisciplinary training in which cutting-edge genomic and genetic engineering approaches are ombined with various in vitro and in vivo disease models. Moreover, together with our private partners we aim at translating our molecular findings into new diagnostic and therapeutic strategies.

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