Explore the words cloud of the ENHPATHY project. It provides you a very rough idea of what is the project "ENHPATHY" about.
The following table provides information about the project.
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
|Coordinator Country||France [FR]|
|Total cost||3˙992˙397 €|
|EC max contribution||3˙992˙397 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2020-03-01 to 2024-02-29|
Take a look of project's partnership.
|1||INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE||FR (PARIS)||coordinator||274˙802.00|
|2||KOBENHAVNS UNIVERSITET||DK (KOBENHAVN)||participant||297˙522.00|
|3||SYDDANSK UNIVERSITET||DK (ODENSE M)||participant||297˙522.00|
|4||KUNGLIGA TEKNISKA HOEGSKOLAN||SE (STOCKHOLM)||participant||281˙982.00|
|5||ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE||CH (LAUSANNE)||participant||281˙276.00|
|6||ADVANCED BIODESIGN||FR (SAINT-PRIEST)||participant||274˙802.00|
|8||GEN-X BV||NL (AMSTERDAM)||participant||265˙619.00|
|9||KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW||NL (AMSTERDAM)||participant||265˙619.00|
|10||HUMANITAS UNIVERSITY||IT (PIEVE EMANUELE)||participant||261˙499.00|
|11||EUROPEAN MOLECULAR BIOLOGY LABORATORY||DE (HEIDELBERG)||participant||252˙788.00|
|12||FUNDACIO CENTRE DE REGULACIO GENOMICA||ES (BARCELONA)||participant||250˙904.00|
|13||UNIVERSIDAD DE CANTABRIA||ES (SANTANDER)||participant||250˙904.00|
|14||USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE||CZ (PRAHA 4)||participant||234˙871.00|
|15||UNIWERSYTET WARSZAWSKI||PL (WARSZAWA)||participant||227˙478.00|
Mutations within coding genes have traditionally been considered the major genetic cause of human disease. However, it is becoming increasingly clear that the genetic, structural and/or epigenetic disruption of enhancers and enhancer landscapes represent major etiological factors in numerous human diseases (i.e. enhanceropathies), ranging from rare congenital disorders to common diseases associated with ageing (e.g. cancer, diabetes). Although changes in enhancer activity are predicted to have broad pathological and therapeutic implications, we currently have a limited mechanistic understanding of human enhanceropathies. This reflects, at least partly, our still primitive and partial understanding of the mechanisms whereby enhancers can control gene expression. We hypothesize that enhancers are a diverse group of regulatory sequences that can utilize different mechanisms to control gene expression at the transcriptional and/or post-transcriptional level. Consequently, human enhanceropathies are likely to display an equally diverse molecular basis that, we believe, can only be uncovered using highly multidisciplinary systems biology approaches. Chiefly, elucidating the molecular basis of human enhanceropathies has far reaching translational implications, especially considering the pandemic proportions that some of these disorders are acquiring in recent years. Therefore, the major goal of the ENHPATHY network is to provide early-stage researchers with a multidisciplinary training in which cutting-edge genomic and genetic engineering approaches are ombined with various in vitro and in vivo disease models. Moreover, together with our private partners we aim at translating our molecular findings into new diagnostic and therapeutic strategies.
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The information about "ENHPATHY" are provided by the European Opendata Portal: CORDIS opendata.