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Met_Cav SIGNED

Metal-Functionalized Cavitands for a Site-Selective C-H hydroxylation of Aliphatic Compounds

Total Cost €

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EC-Contrib. €

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Partnership

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 Met_Cav project word cloud

Explore the words cloud of the Met_Cav project. It provides you a very rough idea of what is the project "Met_Cav" about.

principles    easily    hydroxylation    industrial    functioning    distinguish    ethane    functional    synthetic    substrates    chemically    benign    position    encapsulated    consequently    bonds    selective    methane    rigid    centers    alkanes    reactive    utmost    substrate    utilizing    decades    mild    overcome    chemical    terminal    chemistry    containing    catalytic    inner    metalloenzymes    structurally    inertness    constructing    pockets    cavitands    selectivity    environmentally    performing    combines    residues    transformation    applicable    variety    feedstock    rationales    underlying    binding    site    fresh    poorly    inert    generation    ing    oxidants    species    commodity    accessible    natural    alcohols    orientation    oxidative    stability    reaction    functionalized    chain    alkyl    molecules    spatial    chemoselectivity    abundant    progress    cavity    hydrophobic    metal    valent    catalysts    chemicals    oxidation    power    sustainable    environment    heavier    interior    oxo    capitalized    converted    groups    differentiation    modern    cheap    desired    nevertheless    affinity   

Project "Met_Cav" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙438˙750 €
 EC max contribution 1˙438˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 1˙438˙750.00

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 Project objective

Selective hydroxylation of abundant, but chemically inert C-H bonds remains one of the great challenges in modern chemistry. Given that the resulting alcohols can easily be converted into a variety of other functional groups, this process is key to the large-scale production of commodity chemicals from a natural feedstock. Consequently, developing sustainable and environmentally benign catalysts capable of performing this transformation by utilizing cheap oxidants is of utmost importance. Such catalysts must be reactive enough to overcome the chemical inertness of C-H bonds, yet avoid over-oxidation, and be able to distinguish the target reaction site from other C-H bonds present. Although in recent decades significant progress has been achieved in catalytic hydroxylation of methane and ethane, selective hydroxylation of heavier alkanes (as well as of alkyl chain residues particularly at the terminal position) is still only possible by natural metalloenzymes. While being environment-friendly and functioning under mild conditions, these natural catalysts are poorly applicable to large-scale industrial processes due to their low stability and high cost. Nevertheless, the underlying principles such as (1) reactive metal centers embedded in hydrophobic pockets, (2) structurally defined reaction environment, and (3) affinity-based differentiation between substrates and products, can be capitalized upon for constructing a new generation of synthetic catalysts. The project will demonstrate how these rationales can be implemented with novel metal-functionalized cavitands – inner cavity containing molecules with a rigid metal-binding site accessible only from their interior. This fresh design combines the oxidative power of high valent metal-oxo species with the chemoselectivity for hydrophobic substrates, necessary to avoid product over-oxidation, while the desired site-selectivity is achieved by a well-defined spatial orientation of the encapsulated substrate molecules.

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The information about "MET_CAV" are provided by the European Opendata Portal: CORDIS opendata.

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