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Met_Cav SIGNED

Metal-Functionalized Cavitands for a Site-Selective C-H hydroxylation of Aliphatic Compounds

Total Cost €

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EC-Contrib. €

0

Partnership

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 Met_Cav project word cloud

Explore the words cloud of the Met_Cav project. It provides you a very rough idea of what is the project "Met_Cav" about.

chemoselectivity    cavity    transformation    oxidants    environment    constructing    oxidation    alkyl    metal    reactive    oxidative    pockets    functionalized    hydrophobic    abundant    applicable    alkanes    substrate    consequently    ethane    chemicals    mild    inertness    catalytic    rationales    site    converted    encapsulated    chain    groups    cheap    bonds    capitalized    distinguish    functional    utilizing    stability    inert    rigid    industrial    generation    reaction    heavier    benign    fresh    ing    progress    centers    alcohols    structurally    binding    environmentally    chemical    overcome    containing    selective    inner    variety    metalloenzymes    hydroxylation    species    feedstock    nevertheless    performing    residues    poorly    orientation    chemistry    terminal    desired    selectivity    synthetic    power    molecules    functioning    modern    spatial    combines    catalysts    easily    interior    oxo    position    valent    methane    commodity    underlying    cavitands    affinity    substrates    decades    utmost    natural    chemically    differentiation    accessible    principles    sustainable   

Project "Met_Cav" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙438˙750 €
 EC max contribution 1˙438˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 1˙438˙750.00

Map

 Project objective

Selective hydroxylation of abundant, but chemically inert C-H bonds remains one of the great challenges in modern chemistry. Given that the resulting alcohols can easily be converted into a variety of other functional groups, this process is key to the large-scale production of commodity chemicals from a natural feedstock. Consequently, developing sustainable and environmentally benign catalysts capable of performing this transformation by utilizing cheap oxidants is of utmost importance. Such catalysts must be reactive enough to overcome the chemical inertness of C-H bonds, yet avoid over-oxidation, and be able to distinguish the target reaction site from other C-H bonds present. Although in recent decades significant progress has been achieved in catalytic hydroxylation of methane and ethane, selective hydroxylation of heavier alkanes (as well as of alkyl chain residues particularly at the terminal position) is still only possible by natural metalloenzymes. While being environment-friendly and functioning under mild conditions, these natural catalysts are poorly applicable to large-scale industrial processes due to their low stability and high cost. Nevertheless, the underlying principles such as (1) reactive metal centers embedded in hydrophobic pockets, (2) structurally defined reaction environment, and (3) affinity-based differentiation between substrates and products, can be capitalized upon for constructing a new generation of synthetic catalysts. The project will demonstrate how these rationales can be implemented with novel metal-functionalized cavitands – inner cavity containing molecules with a rigid metal-binding site accessible only from their interior. This fresh design combines the oxidative power of high valent metal-oxo species with the chemoselectivity for hydrophobic substrates, necessary to avoid product over-oxidation, while the desired site-selectivity is achieved by a well-defined spatial orientation of the encapsulated substrate molecules.

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The information about "MET_CAV" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-13 20:58:26) correctly updated