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LIGHT4LUNGS SIGNED

Inhalable Aerosol Light Source for Controlling Drug-Resistant Bacterial Lung Infections

Total Cost €

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EC-Contrib. €

0

Partnership

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 LIGHT4LUNGS project word cloud

Explore the words cloud of the LIGHT4LUNGS project. It provides you a very rough idea of what is the project "LIGHT4LUNGS" about.

porphyrins    added    mortality    aerosol    encompasses    materials    diseases    toxicity    particles    respiratory    advantage    inhalable    therapeutic    organs    infections    excite    sources    whereby    healthcare    bacteria    host    fibrosis    physical    multidrug    invasive    chronic    irrespective    nanomedicine    light    treatment    tethers    scheme    morbidity    internal    persistent    clinically    science    antimicrobial    nanotechnology    cytotoxic    itself    effect    luminescence    tests    lung    local    oxygen    medicine    models    scientific    cystic    photosensitiser    eliminating    efficacy    photosensitising    species    pathogenic    definition    antibiotics    avoiding    iron    photodynamic    lungs    light4lungs    profile    photonics    elicit    self    patients    replaced    safe    tract    hospital    lack    source    breathable    activation    externally    reactive    bacterial    departs    extended    acquired    paradigms    recalcitrant    free    action    lightning    resistance    drug    tissue    endogenous    eliminated    expertise    combined    combines    photosensitisers   

Project "LIGHT4LUNGS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT QUIMIC DE SARRIA 

Organization address
address: CALLE VIA AUGUSTA 384-394
city: Barcelona
postcode: 8017
website: www.iqs.edu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 3˙493˙625 €
 EC max contribution 3˙493˙625 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT QUIMIC DE SARRIA ES (Barcelona) coordinator 714˙375.00
2    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 593˙125.00
3    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 532˙500.00
4    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) participant 410˙000.00
5    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) participant 372˙500.00
6    CARDIFF SCINTIGRAPHICS LIMITED UK (CARDIFF) participant 336˙875.00
7    SORBONNE UNIVERSITE FR (PARIS) participant 294˙250.00
8    WEDO PROJECT INTELLIGENCE MADE EASY SL ES (BARCELONA) participant 240˙000.00

Map

 Project objective

Light4lungs addresses the problem of antimicrobial resistance in the treatment of chronic lung infections, which are the leading cause of morbidity and mortality in patients with diseases such as cystic fibrosis and hospital-acquired lung infections. The goal is to develop a novel therapeutic scheme for the treatment of the infections, whereby antibiotics will be replaced by inhalable light sources that will excite bacterial endogenous photosensitisers (e.g., iron-free porphyrins), eliminating the pathogenic bacteria by the photodynamic effect (local production of cytotoxic reactive oxygen species by the combined action of light, a photosensitiser and oxygen) irrespective of its multidrug resistance profile. The treatment will be safe for the host tissue because of its lack of self-photosensitising ability. Light4Lungs departs from current paradigms: (1) bacterial infections will be treated without antibiotics, which will be replaced by breathable light sources; (2) bacteria will be eliminated without any externally-added drug, taking advantage of endogenous photosensitisers; (3) a breathable light source will be used to elicit the therapeutic action, avoiding the use of invasive physical tethers to deliver light to the lungs. The project encompasses the development of particles with persistent luminescence, the aerosol technology for activation and delivery to the lungs, and the definition of the treatment parameters through toxicity and efficacy tests in clinically relevant models of respiratory infections. The project combines several different scientific expertise from photonics to medicine. The results will be useful for patients with recalcitrant respiratory tract bacterial infections and will eventually be extended to other diseases in the lungs and in other internal organs. The impact reaches beyond antimicrobial resistance itself and will affect many other fields such as healthcare, nanomedicine, materials science and nanotechnology and lightning

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The information about "LIGHT4LUNGS" are provided by the European Opendata Portal: CORDIS opendata.

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