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ChondUb SIGNED

Identification and characterisation of novel WWP2 substrates and their role in chondrogenesis and osteoarthritis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Outcomes and results

 ChondUb project word cloud

Explore the words cloud of the ChondUb project. It provides you a very rough idea of what is the project "ChondUb" about.

joint    elucidated    immune    learning    ligases    oa    combination    collaborations    degradation    eular    uncover    arthritis    osteoarthritis    drugs    cell    leader    ubiquitin    techniques    aligned    cellular    regulates    dynamics    fellowship    ligase    newcastle    excellence    ubiquitination    biology    performed    record    surgery    craniofacial    young    chief    gt    treatment    conduct    opportunity    acquire    relief    laboratory    characterise    substrates    track    national    previously    molecular    group    chondrogenesis    signalling    models    weissman    wwp2    excellent    health    shown    complementary    replacement    cure    disease    career    form    demographic    centre    horizon2020    prof    arising    cartilage    dr    independent    pathogenesis    cancer    roles    envisage    supervision    poorly    mouse    skills    reinforce    differentiation    stem    multidisciplinary    plays    uk    pain    achievement    diseases    creative    characterised    age    protein    population    signaling    university    10    groups   

Project "ChondUb" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITY OF NEWCASTLE UPON TYNE 

Organization address
address: KINGS GATE
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU
website: http://www.ncl.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website http://research.ncl.ac.uk/chondub/
 Total cost 171˙792 €
 EC max contribution 171˙792 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) coordinator 171˙792.00
2    United States Department of Health and Human Services US (Washington D.C.) partner 0.00

Map

 Project objective

Osteoarthritis (OA), characterised by cartilage degradation, is the most common form of arthritis affecting >10% of the EU population over 60 years of age. The pathogenesis is only poorly understood. There is no cure available and current treatment involves pain relief and joint replacement surgery. WWP2 is an ubiquitin ligase involved in stem cell differentiation, cancer development and immune responses, and importantly plays crucial roles in chondrogenesis and craniofacial development. However, its role in cartilage biology and OA development has not been elucidated. Ubiquitination regulates most signalling pathways and cellular processes. Previously, I have shown that ubiquitination plays a role in OA development. Here I aim to identify and characterise WWP2 substrates using a combination of novel techniques. In addition, I will investigate the role of WWP2 and its substrates in cartilage biology with the goal to uncover molecular targets for OA treatment and other WWP2-related diseases. The project is aligned with the “Health, Demographic Change and Well-Being” and “Understanding disease” challenges of Horizon2020. The work will be performed under supervision of Dr Weissman, Chief of the Laboratory of Protein Dynamics and Signaling at the National Cancer Institute (US) and at “EULAR Centre of Excellence” at Newcastle University (UK) under supervision of Prof Young. Dr Weissman has an excellent track record in ubiquitin ligases biology and development of drugs targeting them and Prof Young in cartilage biology and mouse models of OA. Therefore, both groups are highly complementary for this project and envisage future collaborations arising from this fellowship. During this multidisciplinary project I will acquire new knowledge and will reinforce my research skills by learning novel techniques. It is a great opportunity to conduct a creative and independent research facilitating achievement of my main career goal to become an independent research group leader.

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The information about "CHONDUB" are provided by the European Opendata Portal: CORDIS opendata.

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