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ChondUb SIGNED

Identification and characterisation of novel WWP2 substrates and their role in chondrogenesis and osteoarthritis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ChondUb project word cloud

Explore the words cloud of the ChondUb project. It provides you a very rough idea of what is the project "ChondUb" about.

dr    reinforce    techniques    ligases    chief    substrates    cartilage    uncover    laboratory    fellowship    degradation    learning    cellular    mouse    10    molecular    leader    pathogenesis    health    form    career    record    multidisciplinary    immune    shown    university    signalling    achievement    weissman    regulates    characterised    drugs    osteoarthritis    horizon2020    arthritis    young    surgery    collaborations    groups    biology    protein    poorly    previously    cell    combination    eular    creative    excellent    ubiquitination    population    complementary    age    centre    disease    gt    supervision    ubiquitin    models    replacement    pain    stem    chondrogenesis    wwp2    aligned    diseases    signaling    joint    newcastle    performed    elucidated    track    differentiation    acquire    prof    independent    skills    conduct    demographic    opportunity    group    cure    envisage    characterise    arising    craniofacial    treatment    ligase    national    cancer    oa    dynamics    roles    excellence    plays    relief    uk   

Project "ChondUb" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF NEWCASTLE UPON TYNE 

Organization address
address: KINGS GATE
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU
website: http://www.ncl.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://research.ncl.ac.uk/chondub/
 Total cost 171˙792 €
 EC max contribution 171˙792 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) coordinator 171˙792.00
2    United States Department of Health and Human Services US (Washington D.C.) partner 0.00

Map

 Project objective

Osteoarthritis (OA), characterised by cartilage degradation, is the most common form of arthritis affecting >10% of the EU population over 60 years of age. The pathogenesis is only poorly understood. There is no cure available and current treatment involves pain relief and joint replacement surgery. WWP2 is an ubiquitin ligase involved in stem cell differentiation, cancer development and immune responses, and importantly plays crucial roles in chondrogenesis and craniofacial development. However, its role in cartilage biology and OA development has not been elucidated. Ubiquitination regulates most signalling pathways and cellular processes. Previously, I have shown that ubiquitination plays a role in OA development. Here I aim to identify and characterise WWP2 substrates using a combination of novel techniques. In addition, I will investigate the role of WWP2 and its substrates in cartilage biology with the goal to uncover molecular targets for OA treatment and other WWP2-related diseases. The project is aligned with the “Health, Demographic Change and Well-Being” and “Understanding disease” challenges of Horizon2020. The work will be performed under supervision of Dr Weissman, Chief of the Laboratory of Protein Dynamics and Signaling at the National Cancer Institute (US) and at “EULAR Centre of Excellence” at Newcastle University (UK) under supervision of Prof Young. Dr Weissman has an excellent track record in ubiquitin ligases biology and development of drugs targeting them and Prof Young in cartilage biology and mouse models of OA. Therefore, both groups are highly complementary for this project and envisage future collaborations arising from this fellowship. During this multidisciplinary project I will acquire new knowledge and will reinforce my research skills by learning novel techniques. It is a great opportunity to conduct a creative and independent research facilitating achievement of my main career goal to become an independent research group leader.

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The information about "CHONDUB" are provided by the European Opendata Portal: CORDIS opendata.

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