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THERAUTISM SIGNED

New molecular targets and proof-of-concept therapies for Autism Spectrum Disorders

Total Cost €

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EC-Contrib. €

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Partnership

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Project "THERAUTISM" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙025 €
 EC max contribution 1˙499˙025 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙025.00

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 Project objective

Autism is the major neurodevelopmental health public issue, affecting 1/100 child births worldwide. These disorders are diagnosed before the age of 3, based on behavioural cues: deficits in social interaction and communication as well as stereotyped and restrained behaviours. There is no medication to improve this condition. Most recent molecular targets identified within narrow frameworks (unspecific molecule, single tissue targeted, single disease model used) have failed in clinical trials. My first objective aims at thwarting this autism research gap, unravelling the common molecular and cellular dysfunctions underlying autism-related behaviours across several preclinical models and neuronal circuits. In particular, setting up translatomic analyses in these paradigms will identify and validate new molecular therapeutic targets. I recently deciphered one such molecular substrate, involving the loss of oxytocin transcripts in oxytocinergic axon terminals thus demonstrating the feasibility of this global approach. The second major objective of my project is to hijack the properties of a newly identified protein function to restore this new target and rescue social deficits in different preclinical models of autism. This would yield a novel and safe gene therapy vector which has never been explored before. Altogether, my research project will deliver strategic resources to the scientific and medical communities that will spur the development of new treatment options for autistic patients.

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The information about "THERAUTISM" are provided by the European Opendata Portal: CORDIS opendata.

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