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Canonical and Non-canonical modes of Chromosome Segregation in Oocyte Meiosis

Total Cost €


EC-Contrib. €






 ChromoSOMe project word cloud

Explore the words cloud of the ChromoSOMe project. It provides you a very rough idea of what is the project "ChromoSOMe" about.

scenarios    diversity    specialized    vast    canonical    majority    proliferate    unichromosomal    kinetochore    reproducing    reproductive    embryos    carry    electron    wp1    sexually    gametes    division    mitosis    genome    defective    spontaneous    regulate    chromosomes    wp2    genomes    self    spindle    incorrect    capacity    relies    cells    centrosomal    combining    nematodes    analyzing    inaccuracy    abortion    cell    geometry    considering    fertilization    mechanisms    meiotic    reproduction    oocyte    poorly    single    meiosis    silico    technologies    genomic    modeling    aneuploid    proteomic    decisive    chromosome    haploid    microscopy    obstacle    live    oogenesis    principles    tissues    wealth    species    divisions    individuals    molecular    ploidy    segregation    assembly    nematode    universal    female    oocytes    resolution    drive    disciplinary    rounds    cutting    evolution    edge    homeostasis    replication    biochemistry    parthenogenetic    wp3    machinery    analyze    leads    constraints    coupled    multiplication    components    organisms    follow    diploid    somatic    dissect   

Project "ChromoSOMe" data sheet

The following table provides information about the project.


Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙561˙563 €
 EC max contribution 1˙561˙563 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Cell division is crucial for the development of complex organisms, for the homeostasis of tissues, and for the reproductive capacity of individuals. While most somatic cells are diploid and proliferate through mitosis, multiplication of sexually reproducing species relies on haploid gametes that are generated through a specialized cell division process called meiosis. To achieve this reduction in ploidy, two rounds of chromosome segregation follow a single phase of genome replication. Inaccuracy in this process leads to gametes that carry an incorrect number of chromosomes and to aneuploid embryos after fertilization. In their vast majority, these are non-viable and lead to spontaneous abortion: defective meiotic division is therefore a major obstacle in achieving reproduction. However, the key principles that drive this process are still poorly understood, one main reason being the diversity of the molecular scenarios that have been adopted across evolution to regulate oocyte chromosome segregation. To dissect the key components of oocyte meiotic chromosome segregation, we propose to carry out a multi-disciplinary approach, combining several nematode species with the use of high-resolution live and electron microscopy, cutting edge genomic and proteomic technologies, and biochemistry coupled to in silico modeling. In Work Package 1 (WP1), we will analyze the molecular mechanisms controlling the self-assembly of the chromosome segregation machinery -the meiotic spindle- in the oocyte. WP2 will focus on defining how chromosome segregation is achieved in oocytes with non-canonical kinetochore geometry. WP3 aims at analyzing meiotic divisions in parthenogenetic nematodes with specific meiotic constraints, such as centrosomal oogenesis and unichromosomal genomes. By considering the wealth of mechanisms that can drive chromosome segregation in oocytes, this project will provide decisive steps towards understanding the essential and universal features of female meiosis.

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The information about "CHROMOSOME" are provided by the European Opendata Portal: CORDIS opendata.

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