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Oralis SIGNED

Oralis, The first oral human insulin treatment for Type 2 Diabetes Mellitus

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Oralis project word cloud

Explore the words cloud of the Oralis project. It provides you a very rough idea of what is the project "Oralis" about.

orally    liver    glycaemic    bioavailable    demonstrated    sme    gt    trade    daily    disease    oramed    protein    bn    century    region    market    oral    individuals    capability    treatment    longer    commercialise    considerable    claim    eventual    diabetes    300    annually    stigma    co    sufficient    overcome    injectable    est    finalise    transform    instrument    415m    quality    multiple    efficacy    insulin    therapies    share    649    paradigm    2020    options    injecting    life    5000    trials    agreements    hundreds    social    patient    doses    lives    created    injected    confirm    mellitus    trial    revenue    concentration    patients    globally    49    protects    bgl    first    estimation    caring    billion    injections    blood    181m    morbidities    49m    global    oralis    burden    worth    clinical    lifespans    61    glucose    thousands    huge    tract    adherence    prevention    people    newest    levels    prognosis    last    proven    generate    pain    commercial    solution    t2dm    opens    pod    gastrointestinal    type    creation    harsh    pharmaceuticals   

Project "Oralis" data sheet

The following table provides information about the project.

Coordinator		 ORAMED LTD 

Organization address
address: ELZA ST 2
city: JERUSALEM
postcode: 9370648
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Israel [IL]
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-1
 Funding Scheme SME-1
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ORAMED LTD IL (JERUSALEM) coordinator 50˙000.00

Map

 Project objective

Type 2 Diabetes Mellitus (T2DM) affects 415M people globally, 49M of them within Europe. Caring for these individuals costs Europe €181M billion annually. However, more needs to be done as T2DM and its related co-morbidities claim hundreds of thousands of lives each year in the region. The early control of blood glucose levels (BGL) is the key to the prevention of the disease, and longer lifespans with better prognosis and higher quality of life for T2DM patients. The last century has seen considerable development in T2DM treatment, but the eventual solution to control BGL for many patients are multiple daily insulin injections. This has created a huge global market to be worth €49 billion (est. 2020). The pain, social stigma, and burden associated with injecting insulin contribute to a non-adherence to treatment that has been estimated to be as high as 61%, at a cost 9,649€ per patient per year. Oramed Pharmaceuticals (Oramed) will transform this paradigm with its POD™ technology. It protects protein therapies like insulin from the harsh conditions in the gastrointestinal tract, allowing then to be taken orally. This opens a way into oral insulin treatment to overcome many of the issues contributing to non-adherence of injected insulin treatment in T2DM patients. Using POD™ technology Oramed has produced the first oral insulin and demonstrated its efficacy in Phase II clinical trials with >300 patients and >5000 doses. We have proven oralis capability to deliver to the liver bioavailable insulin at sufficient concentration to produce significant glucose control in all glycaemic parameters in T2DM patients. Through the SME instrument Oramed will finalise the Phase III clinical trial to confirm the efficacy of oralis for glycaemic control in T2DM patients. We have already reach commercial agreements to commercialise oralis. Our estimation is to generate a similar revenue creation and market share as the newest injectable insulin options of €1.7 bn in 5 years.

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The information about "ORALIS" are provided by the European Opendata Portal: CORDIS opendata.

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