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HALOSPATH SIGNED

Halogen metabolism of brown macroalgae and its biological significance in the context of pathologies - An omics approach

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EC-Contrib. €

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Partnership

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 HALOSPATH project word cloud

Explore the words cloud of the HALOSPATH project. It provides you a very rough idea of what is the project "HALOSPATH" about.

significantly    halogen    analytical    macroalgae    medina    ecosystem    mariculture    insights    nothing    transfer    annually    time    ectocarpus    unprecedented    intends    families    halometabolites    explored    lack    losses    significance    complemented    independent    interactions    multigenic    nature    laminaria    mimicking    revealing    gene    resistance    metabolites    knowledgebase    mechanism    seq    pathogens    elucidate    metabolism    20    highlighted    populations    urgency    brown    elicitor    disease    defense    resilience    morphologically    bromo    documentation    pathogen    transcriptomic    induction    scope    outbreaks    date    haloperoxidases    mechanisms    edge    datasets    macroalgal    containing    threat    filamentous    till    containment    marine    proteomics    gender    nevertheless    generate    pathosystem    pathologies    envisaging    causing    lab    exploited    immunity    bioactive    equity    infective    spectacular    understudied    molecular    secrets    acquire    group    peroxidases    metabolomic    biology    skills    transcriptomics    limited    metabolomics    cutting    iodo    macroalga    eurychasma    haloperoxidase    halometabolite    sustainable    halospath    posteriori    infection    host    phylotaxonomy    natural    ecosystems    rna    secondment    expertise    proper    series   

Project "HALOSPATH" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN 

Organization address
address: KING'S COLLEGE REGENT WALK
city: ABERDEEN
postcode: AB24 3FX
website: http://www.abdn.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-11-23   to  2022-11-22

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) coordinator 224˙933.00

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 Project objective

Macroalgal pathogens are a threat to the sustainable development of macroalgal mariculture and natural populations in marine ecosystems, causing spectacular disease outbreaks and significant losses (10-20% annually). The lack of proper posteriori containment and disease management measures has increased the urgency to study macroalgal pathologies. Nevertheless, the biology of macroalgal pathogens is understudied and limited to their documentation and phylotaxonomy. Elicitor-based short-term studies mimicking pathogen infection complemented with recent transcriptomics and proteomics of Ectocarpus-Eurychasma pathosystem highlighted the induction of haloperoxidases as a generic defense mechanism in brown macroalgae. Nothing is known about the nature of metabolites, in particular halometabolites, involved in macroalgal host-pathogen interactions till date. HALOSPATH intends to elucidate the significance of halogen metabolism in defense and immunity mechanisms of the filamentous brown macroalga Ectocarpus (containing one haloperoxidase gene) and the morphologically complex Laminaria (containing two large multigenic families of bromo- and iodo-peroxidases) against pathologies, using an integrated approach of time-series comparative metabolomics, and RNA-seq transcriptomics. This will generate large metabolomic and transcriptomic datasets, offering unprecedented insights to advance the knowledgebase of disease resistance/infection mechanism in macroalgae, revealing the secrets behind the infective success of these pathogens that could be exploited for resilience of macroalgal ecosystem to pathogens. Potential bioactive halometabolite products will be explored during secondment at MEDINA, envisaging transfer of knowledge across EU. This project will significantly advance the scope of existing research in the host lab and contribute to gender equity in research. I will acquire cutting-edge analytical, molecular skills and expertise to lead my own independent research group.

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The information about "HALOSPATH" are provided by the European Opendata Portal: CORDIS opendata.

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