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HALOSPATH SIGNED

Halogen metabolism of brown macroalgae and its biological significance in the context of pathologies - An omics approach

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EC-Contrib. €

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Partnership

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 HALOSPATH project word cloud

Explore the words cloud of the HALOSPATH project. It provides you a very rough idea of what is the project "HALOSPATH" about.

expertise    proteomics    molecular    lab    generate    nothing    revealing    transfer    metabolites    resilience    host    knowledgebase    cutting    threat    induction    exploited    metabolomics    eurychasma    till    multigenic    iodo    documentation    nevertheless    macroalgal    elicitor    bioactive    understudied    halospath    haloperoxidase    macroalgae    series    datasets    filamentous    resistance    elucidate    nature    mariculture    proper    outbreaks    seq    20    complemented    pathologies    natural    insights    limited    pathosystem    halogen    immunity    acquire    edge    transcriptomics    disease    losses    lack    unprecedented    mechanism    causing    pathogen    brown    sustainable    equity    populations    posteriori    analytical    phylotaxonomy    ecosystems    intends    urgency    gene    halometabolite    infection    infective    rna    ectocarpus    spectacular    medina    defense    halometabolites    date    time    annually    transcriptomic    secondment    metabolomic    families    envisaging    containment    explored    gender    laminaria    biology    marine    secrets    bromo    macroalga    haloperoxidases    mechanisms    morphologically    skills    peroxidases    independent    significance    interactions    scope    containing    ecosystem    group    highlighted    metabolism    pathogens    mimicking    significantly   

Project "HALOSPATH" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN 

Organization address
address: KING'S COLLEGE REGENT WALK
city: ABERDEEN
postcode: AB24 3FX
website: http://www.abdn.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-11-23   to  2022-11-22

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) coordinator 224˙933.00

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 Project objective

Macroalgal pathogens are a threat to the sustainable development of macroalgal mariculture and natural populations in marine ecosystems, causing spectacular disease outbreaks and significant losses (10-20% annually). The lack of proper posteriori containment and disease management measures has increased the urgency to study macroalgal pathologies. Nevertheless, the biology of macroalgal pathogens is understudied and limited to their documentation and phylotaxonomy. Elicitor-based short-term studies mimicking pathogen infection complemented with recent transcriptomics and proteomics of Ectocarpus-Eurychasma pathosystem highlighted the induction of haloperoxidases as a generic defense mechanism in brown macroalgae. Nothing is known about the nature of metabolites, in particular halometabolites, involved in macroalgal host-pathogen interactions till date. HALOSPATH intends to elucidate the significance of halogen metabolism in defense and immunity mechanisms of the filamentous brown macroalga Ectocarpus (containing one haloperoxidase gene) and the morphologically complex Laminaria (containing two large multigenic families of bromo- and iodo-peroxidases) against pathologies, using an integrated approach of time-series comparative metabolomics, and RNA-seq transcriptomics. This will generate large metabolomic and transcriptomic datasets, offering unprecedented insights to advance the knowledgebase of disease resistance/infection mechanism in macroalgae, revealing the secrets behind the infective success of these pathogens that could be exploited for resilience of macroalgal ecosystem to pathogens. Potential bioactive halometabolite products will be explored during secondment at MEDINA, envisaging transfer of knowledge across EU. This project will significantly advance the scope of existing research in the host lab and contribute to gender equity in research. I will acquire cutting-edge analytical, molecular skills and expertise to lead my own independent research group.

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The information about "HALOSPATH" are provided by the European Opendata Portal: CORDIS opendata.

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