Opendata, web and dolomites

AGEMEC SIGNED

Age-dependent mechanisms of sporadic Alzheimer’s Disease in patient-derived neurons

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 AGEMEC project word cloud

Explore the words cloud of the AGEMEC project. It provides you a very rough idea of what is the project "AGEMEC" about.

mild    exclusively    spec    strategies    mature    aerobic    neuropsychiatric    suggests    glycolysis    appear    contrast    understand    shows    dependent    ipsc    age    metabolite    illuminate    majority    direct    cognitive    cellular    agnostic    disease    interesting    neuronal    data    impairment    harness    epigenetic    mci    signature    permitting    elusive    cancer    opens    metabolome    explore    signatures    patient    differentiation    profound    treatment    patients    mechanisms    models    transcriptome    preliminary    neurons    mechanistic    first    assays    ins    landscape    ad    differentiated    ultimate    discovered    sporadic    glutamatergic    alzheimer    aging    fail    diseases    fibroblasts    contribution    treatable    de    switch    interface    malfunction    regulators    pathology    probably    manner    surprisingly    started    preserves    earliest    connection    overwhelming    combine    neuroscience    avenues    serotonergic    mass    people    human    risk    links    accounts    link    model    anticipate    profiling    metabolic    conversion    manipulating   

Project "AGEMEC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET INNSBRUCK 

Organization address
address: INNRAIN 52
city: INNSBRUCK
postcode: 6020
website: http://www.uibk.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙499˙565 €
 EC max contribution 1˙499˙565 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET INNSBRUCK AT (INNSBRUCK) coordinator 1˙499˙565.00

Map

 Project objective

Sporadic Alzheimer’s Disease (AD) accounts for the overwhelming majority of all AD cases and exclusively affects people at old age. However, mechanistic links between aging and AD pathology remain elusive. We recently discovered that in contrast to iPSC models, direct conversion of human fibroblasts into induced neurons (iNs) preserves signatures of aging, and we have started to develop a patient-based iN model system for AD. Our preliminary data suggests that AD iNs show a neuronal but de-differentiated transcriptome signature. In this project, we first combine cellular neuroscience assays and epigenetic landscape profiling to understand how neurons in AD fail to maintain their fully mature differentiated state, which might be key in permitting disease development. Next, using metabolome analysis including mass spec metabolite assessment, we explore a profound metabolic switch in AD iNs that shows surprisingly many aspects of aerobic glycolysis observed also in cancer. While this link might represent an interesting connection between two age-dependent and de-differentiation-associated diseases, it also opens new avenues to harness knowledge from the cancer field to better understand sporadic AD. We further focus on identifying and manipulating key metabolic regulators that appear to malfunction in an age-dependent manner, with the ultimate goal to define potential targets and treatment strategies. Finally, we will focus on early AD mechanisms by extending our model to mild cognitive impairment (MCI) patients. An agnostic transcriptome and epigenetic landscape approach of glutamatergic and serotonergic iNs will help to determine the earliest and probably most treatable disease mechanisms of AD, and to better understand the contribution of neuropsychiatric risk factors. We anticipate that this project will help to illuminate the mechanistic interface of cellular aging and the development of AD, and help to define new strategies for AD.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "AGEMEC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "AGEMEC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More  

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More