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Microbial deployment of new-to-nature chemistries for refactoring the barriers between living and non-living matter

Total Cost €


EC-Contrib. €






 MADONNA project word cloud

Explore the words cloud of the MADONNA project. It provides you a very rough idea of what is the project "MADONNA" about.

silicon    security    planet    ethical    waste    sustainable    coupled    biologization    herein    chemical    assets    biosphere    robots    global    public    intermediate    industry    code    perceptions    foundational    themselves    agenda    liabilities    safety    synthetic    live    engineered    reverse    suite    settings    capture    gaps    rna    ramifications    successful    overcoming    reactions    simulators    organo    evolution    metabolites    engineer    spin    performance    technologies    automated    nature    cyborg    proteins    tuning    pursued    si    function    bacterial    chassis    flow    instead    fold    uni    fill    fitness    societal    geochemical    dna    biological    chemo    metabolism    unprecedented    prediction    industrial    recruitment    dogma    co2    functioning    environmental    molecular    rarr    of    progressively    directionality    economic    stake    compounds    ntn    governance    ized    biotransformations    elemental    utility    central    entirely    once    carrier    biology    types    madonna    physico    lifetime   

Project "MADONNA" data sheet

The following table provides information about the project.


Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website
 Total cost 2˙968˙817 €
 EC max contribution 2˙968˙817 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
3    UNIVERSITAT BASEL CH (BASEL) participant 429˙413.00
4    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 421˙875.00
5    BIOFACTION KG AT (WIEN) participant 410˙310.00
6    Isthmus FR (Paris) participant 327˙500.00
7    UNIVERSIDAD POMPEU FABRA ES (BARCELONA) participant 313˙450.00
8    SORBONNE UNIVERSITE FR (PARIS) participant 100˙227.00


 Project objective

This Project is about bringing a suite of chemical reactions (and its related non-biological compounds and elements) to the biological fold (i.e. their 'biologization') by going beyond the Central Dogma of Molecular Biology (DNA→ RNA→ proteins→ metabolism) through both tuning and overcoming the uni-directionality of the information flow. To reverse-engineer reactions into a biological code, the utility function of the chemical process of interest will be progressively coupled to the fitness function of a live carrier (e.g. an engineered, synthetic or cyborg-ized bacterial chassis), the intermediate steps being supported by automated chemo-robots. The new-to-nature reactions (NTN) pursued within the MADONNA lifetime as case studies will include CO2 capture and recruitment of elemental silicon to become part of essential organo-Si metabolites. Along with the development of the new reactions, the research agenda of the Project will also include the [i] modelling and prediction on the impact of the new biotransformations on the overall functioning of the Biosphere once/if adopted at a large scale by the industrial sector and [ii] design of environmental simulators for evaluating the performance and evolution of the new biological reactions under given physico-chemical settings. With such approaches, MADONNA aims to fill many of the gaps between the 3 types of global-scale processing of chemical elements operating in our planet: Geochemical, Biological and Industrial. The scale of applications of the foundational technologies developed herein (which spin themselves much beyond CO2 and silicon) is unprecedented and a large number of societal ramifications including ethical, security, safety, economic, governance and public perceptions aspects at stake will be included. If successful, MADONNA will enable an entirely new type of sustainable industry in which many types of waste become assets instead of liabilities.


List of deliverables.
Data management plan Open Research Data Pilot 2019-05-16 21:00:47
Morbidostat for heterotic computation of (bio)chemical problems Demonstrators, pilots, prototypes 2019-05-16 21:00:47
An integrated computational frame for merging NTN reactions to extant metabolism Other 2019-05-16 21:00:47
Setup of a Project website and Logo Websites, patent fillings, videos etc. 2019-05-16 21:00:47

Take a look to the deliverables list in detail:  detailed list of MADONNA deliverables.


year authors and title journal last update
List of publications.
2019 Özlem Akkaya, Pablo I. Nikel, Danilo Pérez-Pantoja, Víctor de Lorenzo
Evolving metabolism of 2,4-dinitrotoluene triggers SOS-independent diversification of host cells
published pages: 314-326, ISSN: 1462-2912, DOI: 10.1111/1462-2920.14459
Environmental Microbiology 21/1 2019-05-16
2019 Tomás Aparicio, Víctor de Lorenzo, Esteban Martínez-García
Improved Thermotolerance of Genome-Reduced Pseudomonas putida EM42 Enables Effective Functioning of the P L / c I857 System
published pages: 1800483, ISSN: 1860-6768, DOI: 10.1002/biot.201800483
Biotechnology Journal 14/1 2019-05-16
2018 Max Chavarría, Víctor de Lorenzo
The imbroglio of the physiological Cra effector clarified at last
published pages: 273-277, ISSN: 0950-382X, DOI: 10.1111/mmi.14080
Molecular Microbiology 109/3 2019-05-16
2018 Blai Vidiella, Josep Sardanyés, Ricard Solé
Exploiting delayed transitions to sustain semiarid ecosystems after catastrophic shifts
published pages: 20180083, ISSN: 1742-5689, DOI: 10.1098/rsif.2018.0083
Journal of The Royal Society Interface 15/143 2019-05-16
2018 Pavel Dvořák, Víctor de Lorenzo
Refactoring the upper sugar metabolism of Pseudomonas putida for co-utilization of cellobiose, xylose, and glucose
published pages: 94-108, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.05.019
Metabolic Engineering 48 2019-05-16
2018 Ricard V. Solé, Raúl Montañez, Salva Duran-Nebreda, Daniel Rodriguez-Amor, Blai Vidiella, Josep Sardanyés
Population dynamics of synthetic terraformation motifs
published pages: 180121, ISSN: 2054-5703, DOI: 10.1098/rsos.180121
Royal Society Open Science 5/7 2019-05-16
2018 Gonzalo Durante-Rodríguez, Víctor de Lorenzo, Pablo I. Nikel
A Post-translational Metabolic Switch Enables Complete Decoupling of Bacterial Growth from Biopolymer Production in Engineered Escherichia coli
published pages: 2686-2697, ISSN: 2161-5063, DOI: 10.1021/acssynbio.8b00345
ACS Synthetic Biology 7/11 2019-05-16
2018 Víctor de Lorenzo
Evolutionary tinkering vs. rational engineering in the times of synthetic biology
published pages: , ISSN: 2195-7819, DOI: 10.1186/s40504-018-0086-x
Life Sciences, Society and Policy 14/1 2019-05-16
2018 Özlem Akkaya, Danilo R. Pérez-Pantoja, Belén Calles, Pablo I. Nikel, Víctor de Lorenzo
The Metabolic Redox Regime of Pseudomonas putida Tunes Its Evolvability toward Novel Xenobiotic Substrates
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.01512-18
mBio 9/4 2019-05-16

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The information about "MADONNA" are provided by the European Opendata Portal: CORDIS opendata.

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