Explore the words cloud of the MADONNA project. It provides you a very rough idea of what is the project "MADONNA" about.
The following table provides information about the project.
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
|Coordinator Country||Spain [ES]|
|Total cost||2˙968˙817 €|
|EC max contribution||2˙968˙817 € (100%)|
1. H2020-EU.1.2.1. (FET Open)
|Duration (year-month-day)||from 2018-01-01 to 2021-12-31|
Take a look of project's partnership.
|1||AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS||ES (MADRID)||coordinator||526˙713.00|
|2||EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH||CH (ZUERICH)||participant||439˙327.00|
|3||UNIVERSITAT BASEL||CH (BASEL)||participant||429˙413.00|
|4||UNIVERSITY OF GLASGOW||UK (GLASGOW)||participant||421˙875.00|
|5||BIOFACTION KG||AT (WIEN)||participant||410˙310.00|
|7||UNIVERSIDAD POMPEU FABRA||ES (BARCELONA)||participant||313˙450.00|
|8||SORBONNE UNIVERSITE||FR (PARIS)||participant||100˙227.00|
|9||UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6||FR (PARIS)||participant||0.00|
This Project is about bringing a suite of chemical reactions (and its related non-biological compounds and elements) to the biological fold (i.e. their 'biologization') by going beyond the Central Dogma of Molecular Biology (DNA→ RNA→ proteins→ metabolism) through both tuning and overcoming the uni-directionality of the information flow. To reverse-engineer reactions into a biological code, the utility function of the chemical process of interest will be progressively coupled to the fitness function of a live carrier (e.g. an engineered, synthetic or cyborg-ized bacterial chassis), the intermediate steps being supported by automated chemo-robots. The new-to-nature reactions (NTN) pursued within the MADONNA lifetime as case studies will include CO2 capture and recruitment of elemental silicon to become part of essential organo-Si metabolites. Along with the development of the new reactions, the research agenda of the Project will also include the [i] modelling and prediction on the impact of the new biotransformations on the overall functioning of the Biosphere once/if adopted at a large scale by the industrial sector and [ii] design of environmental simulators for evaluating the performance and evolution of the new biological reactions under given physico-chemical settings. With such approaches, MADONNA aims to fill many of the gaps between the 3 types of global-scale processing of chemical elements operating in our planet: Geochemical, Biological and Industrial. The scale of applications of the foundational technologies developed herein (which spin themselves much beyond CO2 and silicon) is unprecedented and a large number of societal ramifications including ethical, security, safety, economic, governance and public perceptions aspects at stake will be included. If successful, MADONNA will enable an entirely new type of sustainable industry in which many types of waste become assets instead of liabilities.
|Data management plan||Open Research Data Pilot||2019-05-16 21:00:47|
|Morbidostat for heterotic computation of (bio)chemical problems||Demonstrators, pilots, prototypes||2019-05-16 21:00:47|
|An integrated computational frame for merging NTN reactions to extant metabolism||Other||2019-05-16 21:00:47|
|Setup of a Project website and Logo||Websites, patent fillings, videos etc.||2019-05-16 21:00:47|
Take a look to the deliverables list in detail: detailed list of MADONNA deliverables.
|year||authors and title||journal||last update|
Ã–zlem Akkaya, Pablo I. Nikel, Danilo PÃ©rez-Pantoja, VÃctor de Lorenzo
Evolving metabolism of 2,4-dinitrotoluene triggers SOS-independent diversification of host cells
published pages: 314-326, ISSN: 1462-2912, DOI: 10.1111/1462-2920.14459
|Environmental Microbiology 21/1||2019-05-16|
TomÃ¡s Aparicio, VÃctor de Lorenzo, Esteban MartÃnez-GarcÃa
Improved Thermotolerance of Genome-Reduced Pseudomonas putida EM42 Enables Effective Functioning of the P L / c I857 System
published pages: 1800483, ISSN: 1860-6768, DOI: 10.1002/biot.201800483
|Biotechnology Journal 14/1||2019-05-16|
Max ChavarrÃa, VÃctor de Lorenzo
The imbroglio of the physiological Cra effector clarified at last
published pages: 273-277, ISSN: 0950-382X, DOI: 10.1111/mmi.14080
|Molecular Microbiology 109/3||2019-05-16|
Blai Vidiella, Josep SardanyÃ©s, Ricard SolÃ©
Exploiting delayed transitions to sustain semiarid ecosystems after catastrophic shifts
published pages: 20180083, ISSN: 1742-5689, DOI: 10.1098/rsif.2018.0083
|Journal of The Royal Society Interface 15/143||2019-05-16|
Pavel DvoÅ™Ã¡k, VÃctor de Lorenzo
Refactoring the upper sugar metabolism of Pseudomonas putida for co-utilization of cellobiose, xylose, and glucose
published pages: 94-108, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.05.019
|Metabolic Engineering 48||2019-05-16|
Ricard V. SolÃ©, RaÃºl MontaÃ±ez, Salva Duran-Nebreda, Daniel Rodriguez-Amor, Blai Vidiella, Josep SardanyÃ©s
Population dynamics of synthetic terraformation motifs
published pages: 180121, ISSN: 2054-5703, DOI: 10.1098/rsos.180121
|Royal Society Open Science 5/7||2019-05-16|
Gonzalo Durante-RodrÃguez, VÃctor de Lorenzo, Pablo I. Nikel
A Post-translational Metabolic Switch Enables Complete Decoupling of Bacterial Growth from Biopolymer Production in Engineered Escherichia coli
published pages: 2686-2697, ISSN: 2161-5063, DOI: 10.1021/acssynbio.8b00345
|ACS Synthetic Biology 7/11||2019-05-16|
VÃctor de Lorenzo
Evolutionary tinkering vs. rational engineering in the times of synthetic biology
published pages: , ISSN: 2195-7819, DOI: 10.1186/s40504-018-0086-x
|Life Sciences, Society and Policy 14/1||2019-05-16|
Ã–zlem Akkaya, Danilo R. PÃ©rez-Pantoja, BelÃ©n Calles, Pablo I. Nikel, VÃctor de Lorenzo
The Metabolic Redox Regime of Pseudomonas putida Tunes Its Evolvability toward Novel Xenobiotic Substrates
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.01512-18
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MADONNA" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "MADONNA" are provided by the European Opendata Portal: CORDIS opendata.