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ChromatinLEGO SIGNED

Chromatin readout: Dissecting the protein-chromatin interaction code in living cells

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ChromatinLEGO project word cloud

Explore the words cloud of the ChromatinLEGO project. It provides you a very rough idea of what is the project "ChromatinLEGO" about.

vivo    unclear    uncover    binding    marks    revealing    mediate    principles    determinants    panel    es    crds    underlying    modifications    neuronal    influence    dissect    cell    cells    dynamic    first    combinatorial    profiling    computational    engineering    multiple    proteome    paradigms    spatiotemporal    systematically    local    recruitment    genomics    protein    recognised    elucidate    manner    function    guided    components    systematic    logic    regulators    epigenome    chromatinlego    interactions    mediates    sites    selectivity    domains    reductionistic    dependent    quantitative    genome    utilise    characterise    specificity    regulation    stem    genomic    throughput    dissecting    crd    despite    living    functional    regulatory    proteins    context    parallel    preferences    overarching    efforts    unified    specialised    composition    organisation    reader    individual    combine    chromatin    mechanisms    specify    mediated    strategy    coordinated   

Project "ChromatinLEGO" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT ZURICH 

Organization address
address: RAMISTRASSE 71
city: ZURICH
postcode: 8006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙999˙375 €
 EC max contribution 1˙999˙375 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (ZURICH) coordinator 1˙999˙375.00

Map

 Project objective

Chromatin modifications are key regulators of genome function. They can be directly recognised by specialised protein reader domains, leading to coordinated recruitment of regulatory proteins to the genome in a dynamic, spatiotemporal manner. Despite many efforts to characterise chromatin-mediated protein recruitment, the underlying principles that determine specificity and how chromatin marks influence the proteome composition at genomic sites in living cells, remain unclear. Here I propose to uncover the underlying logic that mediates specificity between regulatory proteins and chromatin states by using a reductionistic approach that enables us to study these interactions in a controlled and comprehensive manner in living cells. Towards this we combine high-throughput stem cell engineering with functional genomics and computational methods to achieve the following aims: First, we aim to identify and characterise the genome-wide binding preferences of a comprehensive panel of chromatin reader domains (CRD) by using a novel strategy for comparative profiling of multiple protein-genome interactions in parallel. Second, we will systematically dissect the context-dependent determinants that mediate individual and combinatorial CRD binding to the genome. Finally, we will utilise the selectivity of CRDs to uncover the local proteome at defined chromatin states in ES and neuronal cells, revealing novel components involved in the regulation and organisation of the epigenome. The overarching goal of ChromatinLEGO is to elucidate in a systematic, quantitative and unified manner, how protein-genome interactions are guided by specific chromatin modifications. Through identifying the chromatin-dependent recruitment principles of regulatory factors, and by dissecting the underlying mechanisms that specify these interactions, this study will provide novel paradigms and important advances to our current understanding of chromatin function in vivo.

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The information about "CHROMATINLEGO" are provided by the European Opendata Portal: CORDIS opendata.

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