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Chromatin readout: Dissecting the protein-chromatin interaction code in living cells

Total Cost €


EC-Contrib. €






 ChromatinLEGO project word cloud

Explore the words cloud of the ChromatinLEGO project. It provides you a very rough idea of what is the project "ChromatinLEGO" about.

elucidate    influence    reader    crds    logic    living    characterise    functional    recognised    efforts    specialised    composition    strategy    determinants    uncover    genomic    reductionistic    context    revealing    regulatory    components    quantitative    binding    combinatorial    specify    manner    domains    marks    computational    stem    multiple    mediates    dissect    recruitment    despite    profiling    parallel    function    proteome    chromatin    underlying    cell    overarching    crd    vivo    mediate    sites    specificity    dissecting    mechanisms    systematic    panel    unclear    cells    selectivity    modifications    first    mediated    neuronal    local    dependent    engineering    epigenome    principles    paradigms    organisation    preferences    genome    regulation    coordinated    systematically    es    combine    protein    proteins    throughput    utilise    guided    genomics    interactions    spatiotemporal    dynamic    regulators    individual    chromatinlego    unified   

Project "ChromatinLEGO" data sheet

The following table provides information about the project.


Organization address
address: RAMISTRASSE 71
city: ZURICH
postcode: 8006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙999˙375 €
 EC max contribution 1˙999˙375 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (ZURICH) coordinator 1˙999˙375.00


 Project objective

Chromatin modifications are key regulators of genome function. They can be directly recognised by specialised protein reader domains, leading to coordinated recruitment of regulatory proteins to the genome in a dynamic, spatiotemporal manner. Despite many efforts to characterise chromatin-mediated protein recruitment, the underlying principles that determine specificity and how chromatin marks influence the proteome composition at genomic sites in living cells, remain unclear. Here I propose to uncover the underlying logic that mediates specificity between regulatory proteins and chromatin states by using a reductionistic approach that enables us to study these interactions in a controlled and comprehensive manner in living cells. Towards this we combine high-throughput stem cell engineering with functional genomics and computational methods to achieve the following aims: First, we aim to identify and characterise the genome-wide binding preferences of a comprehensive panel of chromatin reader domains (CRD) by using a novel strategy for comparative profiling of multiple protein-genome interactions in parallel. Second, we will systematically dissect the context-dependent determinants that mediate individual and combinatorial CRD binding to the genome. Finally, we will utilise the selectivity of CRDs to uncover the local proteome at defined chromatin states in ES and neuronal cells, revealing novel components involved in the regulation and organisation of the epigenome. The overarching goal of ChromatinLEGO is to elucidate in a systematic, quantitative and unified manner, how protein-genome interactions are guided by specific chromatin modifications. Through identifying the chromatin-dependent recruitment principles of regulatory factors, and by dissecting the underlying mechanisms that specify these interactions, this study will provide novel paradigms and important advances to our current understanding of chromatin function in vivo.

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The information about "CHROMATINLEGO" are provided by the European Opendata Portal: CORDIS opendata.

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