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POST-IT SIGNED

Pathogen Oriented SNARE Trafficking for Immune Tailoring

Total Cost €

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EC-Contrib. €

0

Partnership

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 POST-IT project word cloud

Explore the words cloud of the POST-IT project. It provides you a very rough idea of what is the project "POST-IT" about.

disease    preliminary    recruitment    antigens    chemistry    turn    phagosome    sensitivity    histocompatibility    macrophages    altered    energy    functional    vaccinations    immune    diseases    microscopy    hypothesize    molecular    toll    pathogen    therapies    lifetime    recognition    orthogonal    cells    dendritic    infectious    trigger    clearance    rster    binding    peptides    alters    receptors    triggers    cell    signaling    dcs    proteins    promoted    imimmune    resonance    fusion    roles    trafficking    prevent    fluorescence    snares    pathogens    flim    snare    autonomous    phagosomal    data    mhc    adaptive    activation    transporters    proteases    oriented    fret    bio    membrane    ingest    antigen    function    transfer    promotes    imaging    resolve    multiple    literature    quantitative    minority    correct    complexes    ouml    self    receptor    mediated    presentation    technique    lacking    harmless    healthy    autoimmune    ingested    phagosomes    phosphorylation   

Project "POST-IT" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2025-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 2˙000˙000.00

Map

 Project objective

ImImmune clearance of infectious diseases requires correct T cell activation by macrophages and dendritic cells (DCs) that present peptides derived from ingested pathogens on major histocompatibility complexes (MHC). Yet, macrophages and DCs also ingest self-antigens present in healthy cells and their presentation might trigger autoimmune disease. Presentation of the minority of ingested pathogens is promoted by so-called phagosome-autonomous trafficking. Here, pathogen binding to Toll-like receptors in phagosomes triggers recruitment of proteases and transporters to these phagosomes, but not to other phagosomes present in the same cell, promoting specific presentation of pathogen-derived peptides. However, a molecular understanding of this pathogen-oriented phagosome-autonomous trafficking is lacking. The goal of this project is to determine how phagosome-autonomous pathogen recognition promotes presentation of pathogen-derived over harmless self-antigens. Based on my preliminary data and literature, I hypothesize that Toll-like receptor signaling triggers phosphorylation of multiple SNARE proteins at the phagosomal membrane. As SNARE phosphorylation can promote or prevent membrane fusion, this alters delivery of proteases and transporters to these phagosomes, which in turn promotes presentation of pathogen-derived peptides. Objective 1 is to determine how SNARE function is altered upon pathogen-recognition in phagosomes using my novel quantitative Förster resonance energy transfer-fluorescence lifetime imaging microscopy (FRET-FLIM)-based technique. Objective 2 is to address how Toll-like receptor-mediated SNARE phosphorylation affects phagosome-autonomous trafficking. Objective 3 is to resolve the functional roles of SNAREs in antigen presentation using a novel bio-orthogonal chemistry-based method. This study will explain the high sensitivity of the adaptive immune system for pathogens and could lead to better vaccinations and therapies for infectious diseases.

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The information about "POST-IT" are provided by the European Opendata Portal: CORDIS opendata.

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