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POST-IT SIGNED

Pathogen Oriented SNARE Trafficking for Immune Tailoring

Total Cost €

0

EC-Contrib. €

0

Partnership

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 POST-IT project word cloud

Explore the words cloud of the POST-IT project. It provides you a very rough idea of what is the project "POST-IT" about.

ingested    roles    literature    histocompatibility    self    orthogonal    imimmune    disease    correct    prevent    membrane    activation    energy    dcs    signaling    oriented    fret    snare    lacking    proteases    diseases    resonance    toll    preliminary    ouml    cell    trafficking    ingest    phagosome    quantitative    complexes    autonomous    mhc    minority    resolve    pathogen    flim    recruitment    peptides    promoted    multiple    vaccinations    receptor    adaptive    fusion    therapies    presentation    harmless    clearance    binding    recognition    antigens    imaging    transporters    macrophages    data    alters    autoimmune    snares    chemistry    immune    fluorescence    infectious    receptors    phagosomal    rster    microscopy    cells    phagosomes    technique    promotes    transfer    antigen    dendritic    triggers    functional    trigger    turn    mediated    function    molecular    altered    healthy    pathogens    phosphorylation    bio    hypothesize    sensitivity    proteins    lifetime   

Project "POST-IT" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2025-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 2˙000˙000.00

Map

 Project objective

ImImmune clearance of infectious diseases requires correct T cell activation by macrophages and dendritic cells (DCs) that present peptides derived from ingested pathogens on major histocompatibility complexes (MHC). Yet, macrophages and DCs also ingest self-antigens present in healthy cells and their presentation might trigger autoimmune disease. Presentation of the minority of ingested pathogens is promoted by so-called phagosome-autonomous trafficking. Here, pathogen binding to Toll-like receptors in phagosomes triggers recruitment of proteases and transporters to these phagosomes, but not to other phagosomes present in the same cell, promoting specific presentation of pathogen-derived peptides. However, a molecular understanding of this pathogen-oriented phagosome-autonomous trafficking is lacking. The goal of this project is to determine how phagosome-autonomous pathogen recognition promotes presentation of pathogen-derived over harmless self-antigens. Based on my preliminary data and literature, I hypothesize that Toll-like receptor signaling triggers phosphorylation of multiple SNARE proteins at the phagosomal membrane. As SNARE phosphorylation can promote or prevent membrane fusion, this alters delivery of proteases and transporters to these phagosomes, which in turn promotes presentation of pathogen-derived peptides. Objective 1 is to determine how SNARE function is altered upon pathogen-recognition in phagosomes using my novel quantitative Förster resonance energy transfer-fluorescence lifetime imaging microscopy (FRET-FLIM)-based technique. Objective 2 is to address how Toll-like receptor-mediated SNARE phosphorylation affects phagosome-autonomous trafficking. Objective 3 is to resolve the functional roles of SNAREs in antigen presentation using a novel bio-orthogonal chemistry-based method. This study will explain the high sensitivity of the adaptive immune system for pathogens and could lead to better vaccinations and therapies for infectious diseases.

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The information about "POST-IT" are provided by the European Opendata Portal: CORDIS opendata.

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