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CCT SIGNED

The psychology and neurobiology of cognitive control training in humans

Total Cost €

EC-Contrib. €

Partnership

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CCT project word cloud

Explore the words cloud of the CCT project. It provides you a very rough idea of what is the project "CCT" about.

neurobiology avoidance neurophysiology stimuli emotion differences subproject statistical 36 helping alcohol behavioural gabaergic trial reveal impulsive mediate fmri clinical discover despite outcomes weight actions works inhibition microstructure guardian complete nature moderators brain regions therapy influence remote altered relate tms produces reward addiction internet power function regulates suitability determined little adjunct cortex overeating cct costly behaviours influences white causal training thoughts benefits dangerous cognitive structure alters motor emerged worldwide 2a imaging determinants predicted concurrent consumption implications prefrontal producing recruiting stimulation effect promises life individual 2b effectiveness inappropriate coupling reducing

Project "CCT" data sheet

The following table provides information about the project.

Coordinator	CARDIFF UNIVERSITY Organization address address: NEWPORT ROAD 30-36 city: CARDIFF postcode: CF24 ODE website: www.cardiff.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙998˙305 €
EC max contribution	1˙998˙305 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-11-01 to 2020-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CARDIFF UNIVERSITY CARDIFF UNIVERSITY Organization address address: NEWPORT ROAD 30-36 city: CARDIFF postcode: CF24 ODE website: www.cardiff.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CARDIFF)	coordinator	1˙998˙305.00

Map

Project objective

Cognitive control regulates our thoughts and actions, helping us avoid impulsive behaviours that are inappropriate, costly or dangerous. In recent years, evidence has emerged that training in behavioural tasks that promote response inhibition or avoidance of specific stimuli can enhance cognitive control, reducing overeating and alcohol consumption. Despite the promising nature of cognitive control training (CCT), we know little about which CCT methods are most effective, how individual differences determine training outcomes, whether CCT produces benefits for real-life behaviour, and how CCT alters – and is determined by – the structure and function of the brain. My aim is to discover what works in CCT and how the effects of training relate to neurophysiology. Subproject 1 will be the largest ever trial on the effectiveness of different CCT methods for achieving weight loss, recruiting 36,000 participants worldwide to complete an internet-based training programme via the Guardian. This study will reveal, with high statistical power, which CCT methods are the most effective and which individual differences are most important for producing real-life benefits. Subproject 2 will investigate how CCT influences neurobiology, and how individual differences in neurobiology influence CCT outcomes. In Subproject 2a, I will focus on theoretically predicted changes to GABAergic systems in prefrontal and motor cortex, and I will test the effect of GABAergic brain stimulation on training outcomes. In Subproject 2b, I will use concurrent brain stimulation (TMS) and brain imaging (fMRI) to test how CCT alters top-down coupling between prefrontal cortex and remote regions that mediate reward and emotion. I will also study how CCT alters, and is altered by, white matter microstructure. This project promises to advance understanding of the causal determinants and moderators of CCT, with implications for its suitability as a clinical adjunct in addiction therapy and behaviour change.

Publications

List of publications.
year	authors and title	journal	last update
2018	Lindsay Walker, Natalia S. Lawrence, Christopher D. Chambers, Marsha Wood, Julie Barnett, Hannah Durrant, Lindsey Pike, Gerard Oâ€™Grady, Sven Bestmann, Andrew Kythreotis (under review) Supporting evidence-informed policy and scrutiny: a consultation of UK research professionals published pages: , ISSN: 1932-6203, DOI: 10.31235/osf.io/59snr	PLOS ONE	2019-06-06
2018	L. Maizey, R.C. Adams, N.S. Lawrence, F. Verbruggen, C.D. Chambers The neurobiology of cognitive control training as a weight loss aid published pages: 461, ISSN: 0195-6663, DOI: 10.1016/j.appet.2017.11.055	Appetite 123	2019-06-06
2018	Jemma Sedgmond, Natalia S. Lawrence, Frederick Verbruggen, Sinead Morrison, Christopher D. Chambers, Rachel C. Adams (under review) Prefrontal brain stimulation during food-related inhibition training: Effects on food craving, food consumption and inhibitory control published pages: , ISSN: 2054-5703, DOI:	Royal Society Open Science	2019-06-06
2018	Loukia Tzavella, Leah Maizey, Andrew Lawrence, Christopher D. Chambers (under review) Stage 1 Registered Report: The role of healthiness and explicit liking in food-related affective priming published pages: , ISSN: 1069-9384, DOI:	Psychonomic Bulletin & Review	2019-06-06
2018	R.C. Adams, L. Maizey, N.S. Lawrence, F. Frederick Verbruggen, C.D. Chambers Cognitive control training to reduce overeating and promote weight loss: A large online randomised controlled trial published pages: 467, ISSN: 0195-6663, DOI: 10.1016/j.appet.2017.11.075	Appetite 123	2019-06-06
2016	Rachel C. Adams, Natalia S. Lawrence, Kate Button, Christopher D. Chambers Preregistered protocol: The effects of training response inhibition on self-reported liking of unhealthy foods: a replication study investigating moderators of training response published pages: , ISSN: , DOI:		2019-06-06
2018	Loukia Tzavella, Natalia S. Lawrence, Kate Button, Christopher D. Chambers, Rachel C. Adams Preregistered Protocol: The effect of inhibition training on approach-avoidance tendencies for unhealthy foods published pages: , ISSN: , DOI:		2019-06-06
2017	Anne Eileen Campbell, Christopher D. Chambers, Christopher P.G. Allen, Craig Hedge, Petroc Sumner Impairment of manual but not saccadic response inhibition following acute alcohol intoxication published pages: 242-254, ISSN: 0376-8716, DOI: 10.1016/j.drugalcdep.2017.08.022	Drug and Alcohol Dependence 181	2019-06-06
2017	Loukia Tzavella, Frederick Verbruggen, Christopher D. Chambers Preregistered protocol: Testing the efficacy of a novel inhibitory control training protocol for altering food preferences published pages: , ISSN: , DOI:		2019-06-06

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