Explore the words cloud of the PArtCell project. It provides you a very rough idea of what is the project "PArtCell" about.
The following table provides information about the project.
DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV
|Coordinator Country||Germany [DE]|
|Total cost||1˙994˙956 €|
|EC max contribution||1˙994˙956 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2020-03-01 to 2025-02-28|
Take a look of project's partnership.
|1||DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV||DE (AACHEN)||coordinator||1˙994˙956.00|
In the crowded cell, nonspecific interactions between biomolecules alter biochemical equilibria. This matrix of weak nonspecific interactions is composed of hydrophobic, electrostatic, H-bonding, van der Waals, and steric interactions, and is “the dark matter of biology”.
Inaccurate prediction of the behaviour of biomolecules inside cells hampers drug discovery: A high throughput drug screen against a purified target protein in dilute buffer ignores the presence of these weak interactions and results are less relevant. High throughput screens directly in cells are however more difficult to control, interpret and measure.
PArtCell provides a key advance by combining the high level of control and ease of high-throughput screening on purified proteins, with the relevance of screening in the native environment.
The aim is to construct artificial cells that provide a physiologically relevant drug-screening platform.
We will achieve this aim by constructing artificial cells with a matrix of weak nonspecific interactions akin living cells as verified with newly engineered fluorescent probes. The probes measure hydrophobicity, electrostatics and steric effects, as well as the physicochemical state of pathogenic condensates, in healthy and stressed living cells. With this information, we will benchmark artificial cells. Drug screens are applied against pathogenic oligomers that we now can observe in these well-characterized artificial cells.
This research will update textbook knowledge and provide the molecular origin of the matrix of weak nonspecific interactions in living cells. It provides a platform that allows screening against targets under native-like conditions not achievable with other methods. This research thus provides a new opportunity to screen drugs against diseases for which we have no cure yet.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PARTCELL" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "PARTCELL" are provided by the European Opendata Portal: CORDIS opendata.
The Emergence of Language in Social InteractionRead More
Self-Emulsification Route to NanoEmulsions by Cooling of Industrially Relevant CompoundsRead More
A NUDGE IN THE RIGHTS DIRECTION? REDESIGNING THE ARCHITECTURE OF HUMAN RIGHTS REMEDIESRead More