Opendata, web and dolomites

NICHEADAPT SIGNED

Deciphering the niche adaptations of a gut commensal involved in educating the host immune system

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NICHEADAPT project word cloud

Explore the words cloud of the NICHEADAPT project. It provides you a very rough idea of what is the project "NICHEADAPT" about.

severity    inflammatory    epithelial    microbe    link    critical    induces    broad    pointed    employed    infectious    mediate    disease    life    structures    host    evolution    structure    immunostimulatory    consequence    protecting    flagellated    revealing    striking    unicellular    niche    pathogen    fosters    segmented    developmental    gut    models    driving    ileal    resistance    lack    species    microscopy    humans    establishing    autoimmune    health    surface    activation    localized    stimulate    postnatal    immune    immunological    th17    generation    particle    stage    sfb    iga    vitro    epithelium    tip    commensal    pathogens    first    vertebrate    replicative    exacerbate    genome    allowed    transcriptomics    constraints    poorly    missing    interaction    induction    tlr5    tested    plays    overcame    remained    mass    attachment    sequencing    proteins    co    culturing    techniques    microbiota    maturation    monocolonization    gnotobiology    view    pro    found    integral    discovered    notably    cycle    bacteria    bacterium    intimate    signaling    filamentous    cell    spectrometry    hurdle   

Project "NICHEADAPT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙948 €
 EC max contribution 1˙999˙948 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2021
 Duration (year-month-day) from 2021-01-01   to  2025-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙999˙948.00

Map

 Project objective

The gut microbiota plays an integral part in driving the postnatal maturation of the gut immune system and in protecting the host from pathogens. The commensal segmented filamentous bacteria (SFB) plays a critical role in these processes through its intimate attachment to the ileal epithelium using a unique pointed tip structure on its unicellular ‘infectious’ particle. SFB induces a broad pro-inflammatory immune activation, and notably a striking induction of IgA and Th17 cell responses, that fosters pathogen resistance but can also exacerbate disease severity in a number of autoimmune models, making SFB an important microbe in health and disease. SFB is found in many vertebrate species, including humans, and SFB monocolonization has allowed a detail study of its immunostimulatory potential. However, the unique and complex life-cycle of SFB and SFB’s interaction with the host has remained poorly understood due to a lack of in vitro culturing techniques. We recently overcame this hurdle by establishing the first in vitro SFB-host cell co-culturing system. Using this system, unicellular SFB were discovered to be flagellated and to stimulate TLR5 signaling, revealing a missing link of immunological importance in the SFB life-cycle. This important developmental stage will now be further characterized and its immunological consequence assessed using gnotobiology. State-of-the-art microscopy techniques will be employed to characterize in detail the SFB life-cycle and novel structures discovered during in vitro growth. Unicellular SFB surface proteins will be identified using mass spectrometry, localized on the bacterium and tested for their ability to mediate host cell attachment. In addition, next generation sequencing and transcriptomics will be used to assess SFB genome evolution and SFB niche constraints. Together, this work will lead to a detailed view of the SFB life-cycle and how SFB has adapted to its unique replicative niche at the epithelial surface.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NICHEADAPT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NICHEADAPT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Neurovulnerability (2019)

Molecular mechanisms underlying selective neuronal death in motor neuron diseases

Read More  

SUBMODULAR (2019)

The Power of Randomness and Continuity in Submodular Optimization

Read More  

Photopharm (2020)

Photopharmacology: From Academia toward the Clinic.

Read More  
lastchecktime (2022-05-17 4:33:20) correctly updated