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NICHEADAPT SIGNED

Deciphering the niche adaptations of a gut commensal involved in educating the host immune system

Total Cost €

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EC-Contrib. €

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Partnership

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 NICHEADAPT project word cloud

Explore the words cloud of the NICHEADAPT project. It provides you a very rough idea of what is the project "NICHEADAPT" about.

immunostimulatory    infectious    mediate    tlr5    localized    establishing    hurdle    allowed    ileal    intimate    vitro    host    sfb    structure    epithelial    commensal    constraints    th17    disease    cell    stage    activation    integral    proteins    species    immunological    pro    protecting    cycle    employed    signaling    attachment    interaction    gnotobiology    stimulate    monocolonization    fosters    discovered    techniques    gut    severity    unicellular    tested    niche    induction    microbiota    microscopy    found    inflammatory    maturation    life    first    culturing    spectrometry    co    bacteria    microbe    revealing    autoimmune    pathogen    humans    structures    replicative    driving    notably    induces    overcame    missing    developmental    immune    remained    tip    vertebrate    health    view    transcriptomics    mass    critical    filamentous    flagellated    poorly    bacterium    particle    exacerbate    plays    generation    resistance    genome    lack    pathogens    link    consequence    pointed    segmented    postnatal    epithelium    models    sequencing    striking    evolution    broad    iga    surface   

Project "NICHEADAPT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙948 €
 EC max contribution 1˙999˙948 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2021
 Duration (year-month-day) from 2021-01-01   to  2025-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙999˙948.00

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 Project objective

The gut microbiota plays an integral part in driving the postnatal maturation of the gut immune system and in protecting the host from pathogens. The commensal segmented filamentous bacteria (SFB) plays a critical role in these processes through its intimate attachment to the ileal epithelium using a unique pointed tip structure on its unicellular ‘infectious’ particle. SFB induces a broad pro-inflammatory immune activation, and notably a striking induction of IgA and Th17 cell responses, that fosters pathogen resistance but can also exacerbate disease severity in a number of autoimmune models, making SFB an important microbe in health and disease. SFB is found in many vertebrate species, including humans, and SFB monocolonization has allowed a detail study of its immunostimulatory potential. However, the unique and complex life-cycle of SFB and SFB’s interaction with the host has remained poorly understood due to a lack of in vitro culturing techniques. We recently overcame this hurdle by establishing the first in vitro SFB-host cell co-culturing system. Using this system, unicellular SFB were discovered to be flagellated and to stimulate TLR5 signaling, revealing a missing link of immunological importance in the SFB life-cycle. This important developmental stage will now be further characterized and its immunological consequence assessed using gnotobiology. State-of-the-art microscopy techniques will be employed to characterize in detail the SFB life-cycle and novel structures discovered during in vitro growth. Unicellular SFB surface proteins will be identified using mass spectrometry, localized on the bacterium and tested for their ability to mediate host cell attachment. In addition, next generation sequencing and transcriptomics will be used to assess SFB genome evolution and SFB niche constraints. Together, this work will lead to a detailed view of the SFB life-cycle and how SFB has adapted to its unique replicative niche at the epithelial surface.

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The information about "NICHEADAPT" are provided by the European Opendata Portal: CORDIS opendata.

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