Explore the words cloud of the SynWaiXen project. It provides you a very rough idea of what is the project "SynWaiXen" about.
The following table provides information about the project.
|Coordinator Country||Austria [AT]|
|Total cost||174˙167 €|
|EC max contribution||174˙167 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2020-03-01 to 2022-02-28|
Take a look of project's partnership.
|1||UNIVERSITAET INNSBRUCK||AT (INNSBRUCK)||coordinator||174˙167.00|
The realization of the first total syntheses of the two marine natural products waixenicin A and xenibellol A is the aim of this proposal. For this purpose, a N-heterocyclic carben (NHC)-catalyzed bicyclization shall be employed as key transformation. Both target structures are members of the Xenia diterpenoids family and exhibit cytotoxicity against human cancer cell lines. Despite these highly desirable, promising biological properties and unique structural features, therapeutic applications have been prevented by the circumstance that no synthetic access has been achieved until this day. Using retrosynthetic pattern recognition, we realized that the central fused lactone motif (of both natural products) could be efficiently accessed via a recently reported NHC-catalyzed bicyclization reaction. This organocatalytic methodology enables a rapid creation of molecular complexity and, therefore, its application to these total syntheses should save time and other resources. If a therapeutic potential can be corroborated, a synthetic access would provide this family of Xenia diterpenoids (or their derivatives) as possible anticancer drugs. As a result, this project could potentially lead to an improvement of medical care for future cancer patients, thereby also addressing a UN sustainable development goal.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYNWAIXEN" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "SYNWAIXEN" are provided by the European Opendata Portal: CORDIS opendata.
How other minds are represented in the human brain: Neural computations underlying Theory of MindRead More
Retrospective genomic analyses of shortfin Mako shark (Isurus oxyrinchus) using DNA from archived jawsRead More
Mathematics AnalogiesRead More