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SynWaiXen SIGNED

Total Synthesis of Waixenicin A and Xenibellol A

Total Cost €

EC-Contrib. €

Partnership

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SynWaiXen project word cloud

Explore the words cloud of the SynWaiXen project. It provides you a very rough idea of what is the project "SynWaiXen" about.

fused reported creation members anticancer rapid save structures cytotoxicity derivatives syntheses recognition exhibit motif improvement catalyzed first diterpenoids xenia biological family time total organocatalytic heterocyclic molecular lines structural circumstance therapeutic prevented central transformation retrosynthetic thereby carben bicyclization complexity nhc cancer realization lactone methodology desirable patients purpose marine corroborated natural despite until xenibellol potentially realized pattern care employed day medical un reaction waixenicin sustainable synthetic cell human accessed drugs

Project "SynWaiXen" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET INNSBRUCK Organization address address: INNRAIN 52 city: INNSBRUCK postcode: 6020 website: http://www.uibk.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Total cost	174˙167 €
EC max contribution	174˙167 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-EF-ST
Starting year	2020
Duration (year-month-day)	from 2020-03-01 to 2022-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET INNSBRUCK UNIVERSITAET INNSBRUCK Organization address address: INNRAIN 52 city: INNSBRUCK postcode: 6020 website: http://www.uibk.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (INNSBRUCK)	coordinator	174˙167.00

Map

Project objective

The realization of the first total syntheses of the two marine natural products waixenicin A and xenibellol A is the aim of this proposal. For this purpose, a N-heterocyclic carben (NHC)-catalyzed bicyclization shall be employed as key transformation. Both target structures are members of the Xenia diterpenoids family and exhibit cytotoxicity against human cancer cell lines. Despite these highly desirable, promising biological properties and unique structural features, therapeutic applications have been prevented by the circumstance that no synthetic access has been achieved until this day. Using retrosynthetic pattern recognition, we realized that the central fused lactone motif (of both natural products) could be efficiently accessed via a recently reported NHC-catalyzed bicyclization reaction. This organocatalytic methodology enables a rapid creation of molecular complexity and, therefore, its application to these total syntheses should save time and other resources. If a therapeutic potential can be corroborated, a synthetic access would provide this family of Xenia diterpenoids (or their derivatives) as possible anticancer drugs. As a result, this project could potentially lead to an improvement of medical care for future cancer patients, thereby also addressing a UN sustainable development goal.

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The information about "SYNWAIXEN" are provided by the European Opendata Portal: CORDIS opendata.