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DIVISION BELL SIGNED

The role of TETRASPANINS in plant cell division orientation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DIVISION BELL project word cloud

Explore the words cloud of the DIVISION BELL project. It provides you a very rough idea of what is the project "DIVISION BELL" about.

light    bulk    despite    animals    divisions    bioimaging    decisions    single    biology    scaffolds    thrilling    genome    provides    switch    play    cortical    decide    mechanism    imaging    conserved    tets    regulation    act    putative    cell    periclinal    sequencing    morphogenesis    notch    divide    developmental    innovative    remarkable    anticlinal    plasma    edge    organizing    plants    shed    found    plant    transcriptional    expertise    executors    translate    tetraspanin    molecular    vital    conceptual    function    editing    overlap    cells    functions    arabidopsis    validate    elusive    prime    cutting    plane    proteomics    tet    genes    host    trafficking    techniques    direction    orientation    lab    unpublished    plausible    membrane    candidates    family    root    datasets    division    scaffolding    roles    vascular    zone    contrast    how    rna    eukaryotes    bell    proteins    unravel    regulates    signaling    science    tissues    combine    me   

Project "DIVISION BELL" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 178˙320 €
 EC max contribution 178˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 178˙320.00

Map

 Project objective

How do plant cells decide in which direction to divide? Despite many years of research, we still do not know. This is remarkable, because the selection of the division plane is one of the most important developmental decisions a plant cell has to make throughout its growth. My host lab recently identified the transcriptional pathway that regulates the switch from anticlinal to periclinal cell divisions in the developing Arabidopsis root vascular tissues. However, the executors that translate this transcriptional program into division plane selection remain elusive. By overlap analysis of unpublished bulk- and single-cell-RNA-sequencing datasets generated recently in my host lab, I found that the TETRASPANIN (TET) genes are prime candidates for such executors of cell division orientation. The TET family is conserved throughout eukaryotes, and in animals, TETs act as molecular scaffolds at the plasma membrane and play important roles in the regulation of membrane trafficking, signaling, cell morphogenesis and other vital processes. In contrast, in plants, the molecular functions of TETs are not known, but their putative scaffolding function provides a plausible mechanism for the regulation of cell division orientation through organizing proteins at the cortical division zone. In DIVISION BELL, I will unravel the molecular function of plant TETs and validate their role in the regulation of cell division orientation during root vascular development. To reach this goal, I will combine my expertise in cell biology and bioimaging with state of the art genome-editing techniques, cutting-edge proteomics and top-notch imaging approaches available at the host institute. This innovative approach will allow me to shed light on the mechanism of cell division orientation regulation by the TETRASPANIN proteins, with the potential to make major conceptual advances in this thrilling field of plant science.

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The information about "DIVISION BELL" are provided by the European Opendata Portal: CORDIS opendata.

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