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Tac1-Ovulation SIGNED

Addressing the Roles of Tachykinins in the Control of Ovulation: Focus on the Substance-P/Tachykinin Receptor Type 1 (Tac1/Tacr1) System

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Tac1-Ovulation project word cloud

Explore the words cloud of the Tac1-Ovulation project. It provides you a very rough idea of what is the project "Tac1-Ovulation" about.

virogenetic    manipulation    relevance    women    anovulation    shown    physiological    female    acts    signaling    ill    family    excitatory    release    regulate    special    substance    ovary    sp    neurons    ovulation    genetic    premature    worldwide    kiss1    neuronal    output    health    mechanisms    gonadotropin    generation    patho    chemo    action    area    map    subfertility    hence    centrally    preovulatory    activation    fertility    ovulatory    modulate    regulators    dreadds    rostral    syndrome    solid    functional    hypothalamic    gnrh    rodents    techniques    unknown    data    monitoring    gonadotropins    tac    preliminary    strategies    reproductive    tac1    coupled    genomics    roles    insufficiency    silencing    mandatory    encoded    drives    ovarian    projections    actions    expand    deteriorating    helping    disorders    mice    surge    brain    amenorrhea    tachykinin    timed    polycystic    suggested    tracing    inhibitory    secretion    nk1r    dysfunction    tacr1    receptor    upstream   

Project "Tac1-Ovulation" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE CORDOBA 

Organization address
address: AVENIDA DE MEDINA AZAHARA 5
city: CORDOBA
postcode: 14005
website: www.uco.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE CORDOBA ES (CORDOBA) coordinator 172˙932.00

Map

 Project objective

Reproductive health is deteriorating worldwide, via as yet unknown mechanisms. The most common cause of in/subfertility in women is ovulatory dysfunction; anovulation being associated to conditions as polycystic ovary syndrome, hypothalamic amenorrhea and premature ovarian insufficiency. Hence, better understanding of the mechanisms controlling ovulation is mandatory for improved management of reproductive disorders. While hypothalamic GnRH neurons are the major output pathway for the brain control of ovulation, upstream Kiss1 neurons, particularly in the rostral hypothalamic area in rodents, have been suggested to be crucial for the timed activation of GnRH neurons and generation of the preovulatory surge of gonadotropins that drives ovulation. However, the major regulators of this Kiss1/GnRH pathway remains ill defined. Substance P (SP, encoded by Tac1), a member of the tachykinin (TAC) family that acts via the receptor, NK1R (encoded by Tacr1), has been shown to centrally regulate gonadotropin release, and, according to our preliminary data, might modulate the pre-ovulatory surge in mice. Yet, the patho-physiological relevance of SP/NK1R signaling in ovulatory control needs to be defined. Here, we will apply functional genomics and virogenetic approaches to assess the roles and mechanisms of action of SP/NK1R signaling in the control of ovulation, with special attention to its actions in Kiss1 and GnRH neurons. To this end, we will apply (i) virogenetic-driven Tacr1 silencing in Kiss1 and GnRH neurons; (ii) tracing techniques to map Tac1 neuronal projections to Kiss1 and GnRH neurons; and (ii) chemo-genetic manipulation of Tac1 neurons, via excitatory and inhibitory DREADDs, coupled to monitoring of gonadotropin secretion and ovulation. Our project, which is based on our solid preliminary data, will expand our understanding of the mechanisms controlling ovulation and female fertility, helping to define novel strategies for reproductive control in the future.

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The information about "TAC1-OVULATION" are provided by the European Opendata Portal: CORDIS opendata.

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