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Tac1-Ovulation SIGNED

Addressing the Roles of Tachykinins in the Control of Ovulation: Focus on the Substance-P/Tachykinin Receptor Type 1 (Tac1/Tacr1) System

Total Cost €


EC-Contrib. €






 Tac1-Ovulation project word cloud

Explore the words cloud of the Tac1-Ovulation project. It provides you a very rough idea of what is the project "Tac1-Ovulation" about.

tac    expand    gonadotropins    area    rodents    ill    patho    functional    gnrh    deteriorating    physiological    hypothalamic    projections    neuronal    preliminary    drives    kiss1    strategies    genomics    female    hence    upstream    regulate    brain    shown    centrally    special    encoded    data    disorders    suggested    output    genetic    amenorrhea    rostral    worldwide    chemo    polycystic    anovulation    modulate    mechanisms    unknown    map    dysfunction    timed    fertility    dreadds    family    women    nk1r    relevance    virogenetic    ovulation    subfertility    coupled    excitatory    tracing    syndrome    preovulatory    inhibitory    helping    manipulation    secretion    neurons    ovary    mice    ovulatory    regulators    action    techniques    reproductive    generation    mandatory    release    surge    silencing    tac1    signaling    substance    acts    sp    monitoring    actions    receptor    tacr1    premature    ovarian    activation    gonadotropin    insufficiency    health    roles    solid    tachykinin   

Project "Tac1-Ovulation" data sheet

The following table provides information about the project.


Organization address
postcode: 14005

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2022-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE CORDOBA ES (CORDOBA) coordinator 172˙932.00


 Project objective

Reproductive health is deteriorating worldwide, via as yet unknown mechanisms. The most common cause of in/subfertility in women is ovulatory dysfunction; anovulation being associated to conditions as polycystic ovary syndrome, hypothalamic amenorrhea and premature ovarian insufficiency. Hence, better understanding of the mechanisms controlling ovulation is mandatory for improved management of reproductive disorders. While hypothalamic GnRH neurons are the major output pathway for the brain control of ovulation, upstream Kiss1 neurons, particularly in the rostral hypothalamic area in rodents, have been suggested to be crucial for the timed activation of GnRH neurons and generation of the preovulatory surge of gonadotropins that drives ovulation. However, the major regulators of this Kiss1/GnRH pathway remains ill defined. Substance P (SP, encoded by Tac1), a member of the tachykinin (TAC) family that acts via the receptor, NK1R (encoded by Tacr1), has been shown to centrally regulate gonadotropin release, and, according to our preliminary data, might modulate the pre-ovulatory surge in mice. Yet, the patho-physiological relevance of SP/NK1R signaling in ovulatory control needs to be defined. Here, we will apply functional genomics and virogenetic approaches to assess the roles and mechanisms of action of SP/NK1R signaling in the control of ovulation, with special attention to its actions in Kiss1 and GnRH neurons. To this end, we will apply (i) virogenetic-driven Tacr1 silencing in Kiss1 and GnRH neurons; (ii) tracing techniques to map Tac1 neuronal projections to Kiss1 and GnRH neurons; and (ii) chemo-genetic manipulation of Tac1 neurons, via excitatory and inhibitory DREADDs, coupled to monitoring of gonadotropin secretion and ovulation. Our project, which is based on our solid preliminary data, will expand our understanding of the mechanisms controlling ovulation and female fertility, helping to define novel strategies for reproductive control in the future.

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The information about "TAC1-OVULATION" are provided by the European Opendata Portal: CORDIS opendata.

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