Opendata, web and dolomites

MechaPattern SIGNED

Coordination between cell identity, tissue mechanics and proportionate patterning during vertebrate eye formation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MechaPattern project word cloud

Explore the words cloud of the MechaPattern project. It provides you a very rough idea of what is the project "MechaPattern" about.

lines    signaling    sheet    link    activation    teleost    deep    feasible    morphogenetic    patterning    movements    generation    paradigm    retinal    plan    precursors    independently    morphogen    foundation    taz    independent    models    mechanisms    integrate    fide    proportionated    intrinsic    spatiotemporal    light    organ    eye    understand    3d    crosstalk    size    experiments    questions    specification    extremely    embryonic    precise    rpe    cells    innovative    morphogenesis    optic    cell    epithelial    microscopy    wnt    modeling    progress    beta    reporter    cup    experts    generate    identity    self    mouse    multiple    protocols    bona    host    regeneration    cutting    invariant    stem    pigmented    interdisciplinary    catenin    technologies    yap    final    map    pattern    amenable    revisited    cups    root    computational    perturbations    vertebrate    mechanical    made    groundwork    analyzing    edge    powerful    vivo    perspective    determinants    relies    context    folding    hubs    unprecedented   

Project "MechaPattern" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-04-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 160˙932.00

Map

 Project objective

The development of an organ requires the precise coordination between pattern formation, morphogenetic movements and the final size of the system. Significant progress has been made in understanding these processes independently. The aim of this proposal is to integrate this information by analyzing coordination hubs, such as the crosstalk between YAP/TAZ and Wntβ-catenin pathways during the specification of the identity and the mechanical properties of the cell. I will use the development of the vertebrate eye as a defined paradigm. To identify intrinsic and relevant properties of this system, the two most powerful and amenable models of eye morphogenesis will be analyzed: the self-generation of 3D optic cups from mouse Embryonic Stem Cells and the in vivo development of the teleost eye. The plan is to generate a spatiotemporal activation map of the main determinants of eye identity and use them to link morphogen signaling with key morphogenetic processes in specific cells. This will be the groundwork to identify the role of retinal pigmented epithelial (RPE) cells during optic cup folding, the context that I will use to understand both the coordination between morphogen patterning (Wnt) and mechanical properties (Yap) of the retinal precursors, and between proportionated patterning and eye size (scale-invariant mechanisms). This proposal relies on the collaboration of multiple experts from the host institute and on the use of already developed bona fide protocols, reporter lines and signaling perturbations experiments, but revisited with cutting-edge technologies, such as light sheet microscopy and computational modeling. Thus, it is an extremely innovative but feasible project to understand deep-root questions of organ formation. Moreover, this interdisciplinary project will open unprecedented opportunities in the field of organ regeneration from a comprehensive morphogenetic perspective, which will be the foundation of my future independent research.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MECHAPATTERN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MECHAPATTERN" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Widow Spider Mating (2020)

Immature mating as a novel tactic of an invasive widow spider

Read More  

TARGET SLEEP (2020)

Boosting motor learning through sleep and targeted memory reactivation in ageing and Parkinson’s disease

Read More  

CP-FTmmW Aminogen (2020)

Chemistry and structure of aminogen radicals using chirped-pulse Fourier transform (sub)millimeter rotational spectroscopy

Read More