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MechaPattern SIGNED

Coordination between cell identity, tissue mechanics and proportionate patterning during vertebrate eye formation

Total Cost €


EC-Contrib. €






 MechaPattern project word cloud

Explore the words cloud of the MechaPattern project. It provides you a very rough idea of what is the project "MechaPattern" about.

plan    experts    generation    root    foundation    unprecedented    fide    technologies    interdisciplinary    context    rpe    mechanisms    understand    activation    beta    questions    mechanical    generate    groundwork    protocols    hubs    cell    morphogen    deep    teleost    retinal    eye    amenable    vertebrate    wnt    precise    perspective    spatiotemporal    independently    map    3d    size    light    multiple    proportionated    extremely    made    microscopy    embryonic    lines    invariant    cups    revisited    specification    cup    precursors    stem    vivo    identity    determinants    self    pattern    organ    link    integrate    morphogenesis    host    paradigm    powerful    edge    cells    relies    analyzing    pigmented    catenin    reporter    epithelial    taz    independent    signaling    perturbations    innovative    patterning    optic    cutting    feasible    movements    yap    intrinsic    crosstalk    mouse    bona    experiments    regeneration    computational    final    modeling    progress    morphogenetic    sheet    models    folding   

Project "MechaPattern" data sheet

The following table provides information about the project.


Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-04-15


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The development of an organ requires the precise coordination between pattern formation, morphogenetic movements and the final size of the system. Significant progress has been made in understanding these processes independently. The aim of this proposal is to integrate this information by analyzing coordination hubs, such as the crosstalk between YAP/TAZ and Wntβ-catenin pathways during the specification of the identity and the mechanical properties of the cell. I will use the development of the vertebrate eye as a defined paradigm. To identify intrinsic and relevant properties of this system, the two most powerful and amenable models of eye morphogenesis will be analyzed: the self-generation of 3D optic cups from mouse Embryonic Stem Cells and the in vivo development of the teleost eye. The plan is to generate a spatiotemporal activation map of the main determinants of eye identity and use them to link morphogen signaling with key morphogenetic processes in specific cells. This will be the groundwork to identify the role of retinal pigmented epithelial (RPE) cells during optic cup folding, the context that I will use to understand both the coordination between morphogen patterning (Wnt) and mechanical properties (Yap) of the retinal precursors, and between proportionated patterning and eye size (scale-invariant mechanisms). This proposal relies on the collaboration of multiple experts from the host institute and on the use of already developed bona fide protocols, reporter lines and signaling perturbations experiments, but revisited with cutting-edge technologies, such as light sheet microscopy and computational modeling. Thus, it is an extremely innovative but feasible project to understand deep-root questions of organ formation. Moreover, this interdisciplinary project will open unprecedented opportunities in the field of organ regeneration from a comprehensive morphogenetic perspective, which will be the foundation of my future independent research.

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The information about "MECHAPATTERN" are provided by the European Opendata Portal: CORDIS opendata.

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