Opendata, web and dolomites

MechaPattern SIGNED

Coordination between cell identity, tissue mechanics and proportionate patterning during vertebrate eye formation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MechaPattern project word cloud

Explore the words cloud of the MechaPattern project. It provides you a very rough idea of what is the project "MechaPattern" about.

cutting    lines    mouse    intrinsic    amenable    relies    link    experiments    perspective    made    bona    movements    3d    deep    sheet    yap    reporter    embryonic    technologies    signaling    powerful    morphogenesis    optic    interdisciplinary    retinal    paradigm    questions    epithelial    edge    independently    revisited    map    generate    microscopy    foundation    eye    spatiotemporal    experts    teleost    feasible    vivo    hubs    rpe    cells    determinants    self    cup    protocols    root    cups    taz    vertebrate    organ    cell    pigmented    understand    multiple    activation    perturbations    extremely    precursors    morphogenetic    models    context    innovative    plan    size    light    invariant    host    morphogen    final    fide    progress    computational    groundwork    specification    unprecedented    beta    stem    identity    regeneration    mechanical    pattern    proportionated    analyzing    folding    generation    integrate    crosstalk    patterning    independent    precise    modeling    wnt    mechanisms    catenin   

Project "MechaPattern" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-04-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 160˙932.00

Map

 Project objective

The development of an organ requires the precise coordination between pattern formation, morphogenetic movements and the final size of the system. Significant progress has been made in understanding these processes independently. The aim of this proposal is to integrate this information by analyzing coordination hubs, such as the crosstalk between YAP/TAZ and Wntβ-catenin pathways during the specification of the identity and the mechanical properties of the cell. I will use the development of the vertebrate eye as a defined paradigm. To identify intrinsic and relevant properties of this system, the two most powerful and amenable models of eye morphogenesis will be analyzed: the self-generation of 3D optic cups from mouse Embryonic Stem Cells and the in vivo development of the teleost eye. The plan is to generate a spatiotemporal activation map of the main determinants of eye identity and use them to link morphogen signaling with key morphogenetic processes in specific cells. This will be the groundwork to identify the role of retinal pigmented epithelial (RPE) cells during optic cup folding, the context that I will use to understand both the coordination between morphogen patterning (Wnt) and mechanical properties (Yap) of the retinal precursors, and between proportionated patterning and eye size (scale-invariant mechanisms). This proposal relies on the collaboration of multiple experts from the host institute and on the use of already developed bona fide protocols, reporter lines and signaling perturbations experiments, but revisited with cutting-edge technologies, such as light sheet microscopy and computational modeling. Thus, it is an extremely innovative but feasible project to understand deep-root questions of organ formation. Moreover, this interdisciplinary project will open unprecedented opportunities in the field of organ regeneration from a comprehensive morphogenetic perspective, which will be the foundation of my future independent research.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MECHAPATTERN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MECHAPATTERN" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Widow Spider Mating (2020)

Immature mating as a novel tactic of an invasive widow spider

Read More  

MY MITOCOMPLEX (2021)

Functional relevance of mitochondrial supercomplex assembly in myeloid cells

Read More  

Inflapoptosis (2019)

Gasdermin D is a novel effector in the extrinsic apoptosis pathway

Read More