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ARISE SIGNED

mAlaRIa Sex dEtermination

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ARISE project word cloud

Explore the words cloud of the ARISE project. It provides you a very rough idea of what is the project "ARISE" about.

stage    wild    forms    carriers    molecular    embark    subset    population    determinants    countries    influence    lab    biological    edge    widen    migevec    genuine    figure    caused    earliest    confident    environment    sex    supervisor    basic    montpellier    single    transmitted    parasite    male    gametocytes    mostly    uncover    basis    harnessing    he    found    whilst    infection    infected    undertaking    female    events    small    developmental    arise    transcriptomics    falciparum    transmitting    roles    talman    blood    dr    trajectory    group    endemic    cycle    dimorphism    supporting    commitment    understand    asexual    sexual    mosquitoes    strain    nf54    propagation    centres    powerful    parasites    invaluable    france    conduct    genus    expertise    malaria    mechanisms    history    transcriptome    cutting    am    replication    natural    mivegec    cell    power    innovative    divert    disease    plasmodium    ird    biology    provides    genes    scrnaseq    populations    unknown   

Project "ARISE" data sheet

The following table provides information about the project.

Coordinator
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT 

Organization address
address: BOULEVARD DE DUNKERQUE 44 CS 90009
city: MARSEILLE
postcode: 13572
website: www.ird.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT FR (MARSEILLE) coordinator 184˙707.00

Map

 Project objective

Malaria is caused by parasites of the genus Plasmodium. Whilst the disease is caused by asexual parasites, only sexual forms are capable of transmitting the infection to mosquitoes. Sexual forms arise from a small subset of blood-stage parasites which divert from the cycle of asexual replication and embark on a sexual developmental trajectory. Targeting the small population of parasites transmitted to mosquitoes would provide a powerful malaria control method. Although several genes have been found to have sex-specific roles, the molecular basis of the sex-determining mechanisms of Plasmodium into one or the other sex is mostly unknown. In this proposal I will apply innovative approaches to uncover the pathway of sex-determination in P. falciparum, in both lab-adapted parasites and wild parasite populations. Specifically, I will (i) determine the earliest events in sexual dimorphism using single-cell transcriptomics (scRNAseq) in a lab-adapted P. falciparum strain (NF54); (ii) understand determinants of malaria sexual determination in wild parasites by harnessing the power of scRNAseq; (iii) identify factors that influence determination into male or female gametocytes in natural parasite populations obtained from infected carriers. My supervisor, Dr Talman, is a leading figure in Plasmodium transcriptome analysis and sexual biology of the parasite. He has recently set up his group in Montpellier at MIGEVEC, one of the top IRD Centres in France. MIVEGEC has a unique and long history of supporting research and provides the best environment to conduct cutting-edge research in the lab as well as in challenging conditions in malaria endemic countries. Although this project represents an ambitious undertaking, I am confident my strong previous experience in malaria research and the genuine commitment to widen my field of expertise will contribute to have a major impact, providing an invaluable insight into a basic biological process essential for parasite propagation.

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The information about "ARISE" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2023-02-05 18:14:58) correctly updated