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Alloem SIGNED

Maternal immune response to allogeneic embryos

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 Alloem project word cloud

Explore the words cloud of the Alloem project. It provides you a very rough idea of what is the project "Alloem" about.

pigs    hypothesis    paradox    death    transcriptomic    maternal    world    highest    70    cytokine    pregnancies    regulating    starting    period    strategies    pregnancy    double    standards    prolificacy    difference    arrested    ivf    recipient    utmost    full    emergent    fertility    efficient    immunological    supporting    reproductive    tissue    semi    free    humans    unrelated    goals    oocytes    donor    fetuses    high    dialogue    animals    porcine    mother    producer    peri    performance    interesting    environments    jeopardize    accounted    endometrial    technologies    implantation    biggest    contain    residue    embryo    et    artificial    unveil    species    fact    allogeneic    welfare    natural    livestock    material    breeding    exporter    embryonic    transferred    pig    immune    almost    genetic    comparatively    placenta    insemination    antibiotic    raised    mechanisms    healthy    ai    transfer    competitiveness    determinant    view    paternal    embryos    sustainability    mortality    regulation   

Project "Alloem" data sheet

The following table provides information about the project.

Coordinator
LINKOPINGS UNIVERSITET 

Organization address
address: CAMPUS VALLA
city: LINKOPING
postcode: 581 83
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LINKOPINGS UNIVERSITET SE (LINKOPING) coordinator 191˙852.00

Map

 Project objective

High embryonic mortality at the peri-implantation period (70%) is accounted after pig embryo transfer (ET), which is almost double than that of natural breeding or artificial insemination (AI). Since pregnancy is an interesting immunological paradox, our starting hypothesis is that the mechanisms regulating the maternal immune response to the embryos may be less efficient in the case of ET pregnancies, where the transferred embryos are allogeneic (e.g. contain paternal and maternal material unrelated to the recipient mother) than after natural breeding or AI, where only paternal material is unrelated to the mother (semi-allogeneic). This difference could be behind the increased embryonic death. The project will study transcriptomic and cytokine changes of porcine endometrial tissue in the presence of semi-allogeneic and allogeneic embryos during the peri-implantation period and also in the placenta of healthy and arrested fetuses. The results of the project will unveil mechanisms behind embryo-maternal dialogue. This fact is relevant in view of the necessary implementation of emergent breeding technologies, as embryo transfer (ET), for supporting sustainability and competitiveness of the European pig sector. EU is currently second biggest pig producer in the world and the largest exporter of antibiotic- and residue-free pig products derived from animals raised on highest welfare standards and with the highest genetic value. The understanding of embryo-maternal dialogue under allogeneic environments might be determinant to implement new strategies to increase the reproductive performance after ET not only in pigs but also, comparatively, in other livestock species and even in humans, where the use of donor oocytes for IVF is currently increasing. This project, with a focus on pregnancy immunological regulation, is of utmost interest for the EU goals, contributing to determine which factors still jeopardize full fertility and prolificacy when applying ET technology.

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The information about "ALLOEM" are provided by the European Opendata Portal: CORDIS opendata.

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