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Alloem SIGNED

Maternal immune response to allogeneic embryos

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Alloem project word cloud

Explore the words cloud of the Alloem project. It provides you a very rough idea of what is the project "Alloem" about.

period    utmost    transferred    fetuses    jeopardize    peri    donor    arrested    biggest    animals    endometrial    pregnancy    performance    paternal    almost    technologies    transfer    ivf    immune    pregnancies    strategies    producer    reproductive    et    pigs    emergent    raised    breeding    pig    goals    ai    prolificacy    natural    insemination    embryos    double    unveil    welfare    world    semi    hypothesis    mother    full    fact    sustainability    oocytes    free    70    determinant    residue    dialogue    supporting    material    interesting    accounted    paradox    exporter    fertility    implantation    difference    genetic    transcriptomic    environments    species    death    highest    allogeneic    artificial    starting    livestock    regulation    unrelated    mortality    placenta    view    immunological    cytokine    porcine    regulating    competitiveness    humans    antibiotic    healthy    comparatively    recipient    maternal    mechanisms    efficient    tissue    high    standards    embryo    embryonic    contain   

Project "Alloem" data sheet

The following table provides information about the project.

Coordinator
LINKOPINGS UNIVERSITET 

Organization address
address: CAMPUS VALLA
city: LINKOPING
postcode: 581 83
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LINKOPINGS UNIVERSITET SE (LINKOPING) coordinator 191˙852.00

Map

 Project objective

High embryonic mortality at the peri-implantation period (70%) is accounted after pig embryo transfer (ET), which is almost double than that of natural breeding or artificial insemination (AI). Since pregnancy is an interesting immunological paradox, our starting hypothesis is that the mechanisms regulating the maternal immune response to the embryos may be less efficient in the case of ET pregnancies, where the transferred embryos are allogeneic (e.g. contain paternal and maternal material unrelated to the recipient mother) than after natural breeding or AI, where only paternal material is unrelated to the mother (semi-allogeneic). This difference could be behind the increased embryonic death. The project will study transcriptomic and cytokine changes of porcine endometrial tissue in the presence of semi-allogeneic and allogeneic embryos during the peri-implantation period and also in the placenta of healthy and arrested fetuses. The results of the project will unveil mechanisms behind embryo-maternal dialogue. This fact is relevant in view of the necessary implementation of emergent breeding technologies, as embryo transfer (ET), for supporting sustainability and competitiveness of the European pig sector. EU is currently second biggest pig producer in the world and the largest exporter of antibiotic- and residue-free pig products derived from animals raised on highest welfare standards and with the highest genetic value. The understanding of embryo-maternal dialogue under allogeneic environments might be determinant to implement new strategies to increase the reproductive performance after ET not only in pigs but also, comparatively, in other livestock species and even in humans, where the use of donor oocytes for IVF is currently increasing. This project, with a focus on pregnancy immunological regulation, is of utmost interest for the EU goals, contributing to determine which factors still jeopardize full fertility and prolificacy when applying ET technology.

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The information about "ALLOEM" are provided by the European Opendata Portal: CORDIS opendata.

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