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FuelVesicles SIGNED

Commercialization of open vesicles to fuel downstream reaction networks

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FuelVesicles project word cloud

Explore the words cloud of the FuelVesicles project. It provides you a very rough idea of what is the project "FuelVesicles" about.

limited    supply    poc    gain    carry    tried    reactions    external    cells    free    time    power    vesicles    nucleic    dissipation    numerous    syntheses    chemical    acids    magnitude    ip    analytics    reserves    biotechnological    stops    functional    synthetic    feasibility    autonomously    strengthen    exist    generation    tests    diphosphate    hasn    vitamins    reaction    mitochondria    scientists    intervention    mimic    away    draining    acid    creates    construct    antibiotics    plan    reported    interaction    triphosphate    adenosine    atp    prepare    periods    proteins    dna    demanding    bottleneck    commercialization    drug    cell    energy    constant    molecules    cascade    minimal    operation    sequencing    evident    bio    sustainable    networks    actions    longer    amino    truly    equilibrium    kept    houses    lasting    biotech    living    chemistry    ratio    removal    cytosol    endergonic    materials    form    drive    completely    autonomous    adp    depletion    operate    mobile    managed    partnering    feeding    life    fuel   

Project "FuelVesicles" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 150˙000.00

Map

 Project objective

Numerous biotechnological processes require Adenosine-5'-triphosphate (ATP) as a form of free energy to drive endergonic reactions. The bottleneck is that after some time the reaction stops due to adenosine diphosphate (ADP) build up and the depletion of energy reserves. In living cells, functional and sustainable out-of-equilibrium networks exist. Scientists have tried to mimic such autonomous systems without the need for external interaction, or fuel supply. Real success hasn’t been reported. We managed to construct a fuel system in synthetic vesicles that is kept away from equilibrium by controlling the energy dissipation. These vesicles are power houses for sustainable production of ATP (and removal of ADP) much like mitochondria power the ATP-demanding reactions in the cytosol of a cell. In further tests, we were able to reach an order of magnitude longer autonomous operation of a real-life application making our approach truly unique. All the comparable approaches focus on feeding the reaction with ATP without draining of the ADP. Our system creates the fuel from an amino acid while the ATP/ADP ratio is kept constant. The gain for applications is evident; the reactions, and therefore systems, can operate autonomously for long periods of time. This is particularly important for mobile systems with limited supply of reaction materials and where user intervention has to be minimal. Therefore, we expect to enable a completely new generation of autonomous biotech and chemistry applications, such as targeted drug delivery, analytics of nucleic acids or proteins, and cascade reactions for (bio)chemical syntheses of antibiotics, vitamins and other complex molecules. In this PoC, we will advance the commercialization of our approach by carrying out a technical feasibility for sustainable production of ATP for long-lasting sequencing of DNA application. In addition, we will prepare a commercialization plan, carry out partnering actions and strengthen the IP further.

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The information about "FUELVESICLES" are provided by the European Opendata Portal: CORDIS opendata.

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