Opendata, web and dolomites
FuelVesicles SIGNED
Commercialization of open vesicles to fuel downstream reaction networks
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0FuelVesicles project word cloud
Explore the words cloud of the FuelVesicles project. It provides you a very rough idea of what is the project "FuelVesicles" about.
vitamins
analytics
sustainable
chemistry
scientists
external
networks
proteins
antibiotics
managed
syntheses
limited
synthetic
dissipation
mitochondria
materials
tried
autonomously
acid
draining
gain
bottleneck
feasibility
hasn
form
biotechnological
ratio
removal
interaction
time
dna
cascade
reported
equilibrium
autonomous
ip
amino
cell
periods
adp
adenosine
biotech
atp
drive
plan
tests
functional
numerous
free
truly
evident
living
triphosphate
chemical
generation
power
longer
completely
acids
reaction
life
diphosphate
feeding
carry
magnitude
endergonic
exist
drug
reactions
away
kept
houses
mobile
demanding
constant
fuel
mimic
operation
cells
vesicles
poc
strengthen
cytosol
nucleic
minimal
bio
operate
commercialization
creates
sequencing
molecules
lasting
partnering
supply
construct
stops
intervention
prepare
energy
reserves
depletion
actions
Project "FuelVesicles" data sheet
The following table provides information about the project.
| Coordinator |
RIJKSUNIVERSITEIT GRONINGEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 0 € |
| EC max contribution | 150˙000 € (0%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-PoC |
| Funding Scheme | ERC-POC-LS |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-04-01 to 2021-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | RIJKSUNIVERSITEIT GRONINGEN | NL (GRONINGEN) | coordinator | 150˙000.00 |
Map
Project objective
Numerous biotechnological processes require Adenosine-5'-triphosphate (ATP) as a form of free energy to drive endergonic reactions. The bottleneck is that after some time the reaction stops due to adenosine diphosphate (ADP) build up and the depletion of energy reserves. In living cells, functional and sustainable out-of-equilibrium networks exist. Scientists have tried to mimic such autonomous systems without the need for external interaction, or fuel supply. Real success hasn’t been reported. We managed to construct a fuel system in synthetic vesicles that is kept away from equilibrium by controlling the energy dissipation. These vesicles are power houses for sustainable production of ATP (and removal of ADP) much like mitochondria power the ATP-demanding reactions in the cytosol of a cell. In further tests, we were able to reach an order of magnitude longer autonomous operation of a real-life application making our approach truly unique. All the comparable approaches focus on feeding the reaction with ATP without draining of the ADP. Our system creates the fuel from an amino acid while the ATP/ADP ratio is kept constant. The gain for applications is evident; the reactions, and therefore systems, can operate autonomously for long periods of time. This is particularly important for mobile systems with limited supply of reaction materials and where user intervention has to be minimal. Therefore, we expect to enable a completely new generation of autonomous biotech and chemistry applications, such as targeted drug delivery, analytics of nucleic acids or proteins, and cascade reactions for (bio)chemical syntheses of antibiotics, vitamins and other complex molecules. In this PoC, we will advance the commercialization of our approach by carrying out a technical feasibility for sustainable production of ATP for long-lasting sequencing of DNA application. In addition, we will prepare a commercialization plan, carry out partnering actions and strengthen the IP further.
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The information about "FUELVESICLES" are provided by the European Opendata Portal: CORDIS opendata.
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