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FuelVesicles SIGNED

Commercialization of open vesicles to fuel downstream reaction networks

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FuelVesicles project word cloud

Explore the words cloud of the FuelVesicles project. It provides you a very rough idea of what is the project "FuelVesicles" about.

autonomous    kept    reported    scientists    adp    exist    molecules    tried    gain    diphosphate    evident    interaction    periods    dissipation    dna    construct    supply    partnering    removal    drug    bio    numerous    cell    drive    hasn    chemistry    time    commercialization    prepare    magnitude    atp    actions    constant    amino    mimic    away    acid    demanding    analytics    autonomously    poc    depletion    feasibility    mitochondria    synthetic    vitamins    cytosol    acids    networks    reaction    reserves    fuel    external    ip    functional    strengthen    antibiotics    plan    form    equilibrium    stops    proteins    endergonic    biotechnological    completely    longer    sustainable    minimal    energy    vesicles    managed    intervention    feeding    carry    limited    living    operation    chemical    truly    lasting    free    cascade    biotech    draining    reactions    houses    power    creates    adenosine    nucleic    cells    sequencing    operate    materials    tests    mobile    generation    syntheses    bottleneck    life    triphosphate    ratio   

Project "FuelVesicles" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 150˙000.00

Map

 Project objective

Numerous biotechnological processes require Adenosine-5'-triphosphate (ATP) as a form of free energy to drive endergonic reactions. The bottleneck is that after some time the reaction stops due to adenosine diphosphate (ADP) build up and the depletion of energy reserves. In living cells, functional and sustainable out-of-equilibrium networks exist. Scientists have tried to mimic such autonomous systems without the need for external interaction, or fuel supply. Real success hasn’t been reported. We managed to construct a fuel system in synthetic vesicles that is kept away from equilibrium by controlling the energy dissipation. These vesicles are power houses for sustainable production of ATP (and removal of ADP) much like mitochondria power the ATP-demanding reactions in the cytosol of a cell. In further tests, we were able to reach an order of magnitude longer autonomous operation of a real-life application making our approach truly unique. All the comparable approaches focus on feeding the reaction with ATP without draining of the ADP. Our system creates the fuel from an amino acid while the ATP/ADP ratio is kept constant. The gain for applications is evident; the reactions, and therefore systems, can operate autonomously for long periods of time. This is particularly important for mobile systems with limited supply of reaction materials and where user intervention has to be minimal. Therefore, we expect to enable a completely new generation of autonomous biotech and chemistry applications, such as targeted drug delivery, analytics of nucleic acids or proteins, and cascade reactions for (bio)chemical syntheses of antibiotics, vitamins and other complex molecules. In this PoC, we will advance the commercialization of our approach by carrying out a technical feasibility for sustainable production of ATP for long-lasting sequencing of DNA application. In addition, we will prepare a commercialization plan, carry out partnering actions and strengthen the IP further.

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The information about "FUELVESICLES" are provided by the European Opendata Portal: CORDIS opendata.

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