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FuelVesicles SIGNED

Commercialization of open vesicles to fuel downstream reaction networks

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 FuelVesicles project word cloud

Explore the words cloud of the FuelVesicles project. It provides you a very rough idea of what is the project "FuelVesicles" about.

completely    sustainable    constant    interaction    biotech    networks    chemical    reserves    kept    biotechnological    form    proteins    nucleic    gain    acids    diphosphate    mimic    materials    cytosol    energy    operation    feeding    supply    truly    reaction    plan    evident    living    bio    antibiotics    operate    autonomous    prepare    synthetic    autonomously    construct    ratio    dissipation    triphosphate    vesicles    generation    longer    intervention    limited    stops    vitamins    creates    dna    periods    syntheses    scientists    mobile    amino    draining    partnering    tried    endergonic    sequencing    strengthen    exist    molecules    time    reactions    mitochondria    commercialization    demanding    adenosine    free    minimal    cascade    away    chemistry    cell    magnitude    tests    actions    reported    analytics    houses    drug    power    life    external    acid    poc    feasibility    adp    equilibrium    hasn    numerous    lasting    fuel    functional    bottleneck    drive    cells    atp    ip    removal    carry    depletion    managed   

Project "FuelVesicles" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 150˙000.00

Map

 Project objective

Numerous biotechnological processes require Adenosine-5'-triphosphate (ATP) as a form of free energy to drive endergonic reactions. The bottleneck is that after some time the reaction stops due to adenosine diphosphate (ADP) build up and the depletion of energy reserves. In living cells, functional and sustainable out-of-equilibrium networks exist. Scientists have tried to mimic such autonomous systems without the need for external interaction, or fuel supply. Real success hasn’t been reported. We managed to construct a fuel system in synthetic vesicles that is kept away from equilibrium by controlling the energy dissipation. These vesicles are power houses for sustainable production of ATP (and removal of ADP) much like mitochondria power the ATP-demanding reactions in the cytosol of a cell. In further tests, we were able to reach an order of magnitude longer autonomous operation of a real-life application making our approach truly unique. All the comparable approaches focus on feeding the reaction with ATP without draining of the ADP. Our system creates the fuel from an amino acid while the ATP/ADP ratio is kept constant. The gain for applications is evident; the reactions, and therefore systems, can operate autonomously for long periods of time. This is particularly important for mobile systems with limited supply of reaction materials and where user intervention has to be minimal. Therefore, we expect to enable a completely new generation of autonomous biotech and chemistry applications, such as targeted drug delivery, analytics of nucleic acids or proteins, and cascade reactions for (bio)chemical syntheses of antibiotics, vitamins and other complex molecules. In this PoC, we will advance the commercialization of our approach by carrying out a technical feasibility for sustainable production of ATP for long-lasting sequencing of DNA application. In addition, we will prepare a commercialization plan, carry out partnering actions and strengthen the IP further.

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The information about "FUELVESICLES" are provided by the European Opendata Portal: CORDIS opendata.

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