Opendata, web and dolomites

FluAttack SIGNED

Validation of a novel antiviral drug candidate against influenza

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FluAttack project word cloud

Explore the words cloud of the FluAttack project. It provides you a very rough idea of what is the project "FluAttack" about.

clinical    molecules    epithelial    context    erc    pandemics    creation    urgently    infections    pandemic    predicted    100nm    hits    model    family    reduce    tests    solution    devastating    virus    stg    anti    agent    cellular    airway    world    few    risk    secure    resistance    time    innovative    economic    extremely    hit    with    cells    licensing    potent    approved    screening    start    inhibitors    lives    replication    societies    pathogens    infection    trials    poc    repurposing    plan    lt    viral    powerful    3d    650    commercial    vivo    treat    rely    lab    mouse    influenza    solutions    data    preclinical    validate    efficacy    escape    prevent    burden    agree    ipr    preventing    million    specialists    respect    action    options    therapeutic    organization    advantage    actually    candidate    perfect    limitations    limited    antivir    function    viruses    mode    human    compounds    deaths    demand    ic50    worldwide    patent    went    molecule    health    cancer    heavy    drug    strategy    characterise    severe    vaccination   

Project "FluAttack" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 139˙081.00
2    CNRS INNOVATION FR (PARIS) participant 10˙919.00

Map

 Project objective

With 3 to 5 million severe cases and up to 650,000 deaths per year worldwide, influenza viruses are not only major human pathogens, they are also a heavy economic burden to our societies. In addition, influenza pandemics can occur at any time with potential devastating effects in terms of lives and costs. Solutions to prevent infection, to treat severe influenza cases and to respond to a severe pandemic are currently extremely limited and rely on vaccination and on only few approved molecules. All these solutions have their limitations with respect to efficacy and all face the problem of viral resistance. Thus, the demand for new options against influenza infections is high. The World Health Organization (WHO) and influenza virus specialists agree that innovative and effective anti-influenza compounds with a reduced risk of viral escape are urgently needed. The main goal of this ERC PoC is to provide key data on a promising innovative therapeutic solution identified in the lab. Taking advantage of a powerful screening system we have developed during the ERC StG ANTIViR, we have identified a family of molecules as potent inhibitors of influenza virus (with IC50<100nM). The mode of action of these molecules is known and they actually target a cellular function essential to all influenza viruses. Preventing viral replication by targeting a cellular function is a novel approach, predicted to strongly reduce the risk of drug resistance. Importantly, one of our hits went through several phase II and III clinical trials as an anti-cancer agent, making this molecule a perfect candidate for drug repurposing. In this context, the specific objectives of this ERC PoC are: i) to further characterise and validate our best hit, in particular in commercial 3D human airway epithelial cells and in vivo in a mouse model, and ii) to secure IPR and to establish an exploitation strategy plan (patent licensing or creation of a start-up) to support future development and preclinical tests.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FLUATTACK" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FLUATTACK" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

OSIRIS (2020)

Automatic measurement of speech understanding using EEG

Read More  

EASY-IPS (2019)

a rapid and efficient method for generation of iPSC

Read More  

ENTRAPMENT (2019)

Septins: from bacterial entrapment to cellular immunity

Read More