Explore the words cloud of the RegARcis project. It provides you a very rough idea of what is the project "RegARcis" about.
The following table provides information about the project.
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
|Coordinator Country||Spain [ES]|
|Total cost||160˙932 €|
|EC max contribution||160˙932 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2020-03-31 to 2022-03-30|
Take a look of project's partnership.
|1||FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE||ES (L'HOSPITALET DE LLOBREGAT)||coordinator||160˙932.00|
The significance of epigenetic deregulation is a very hot topic in current prostate cancer (PC) research. New mutations have been identified in several epigenetic regulators known for their interaction with the AR. In fact, the role of chromatin remodeling factors facilitating enhancer-promoter cooperation in the formation of the AR transcriptional complex has long been demonstrated. Accordingly, the marked redistribution of AR binding sites (cistrome) during tumorigenesis is arguably the most recurrent genetic or epigenetic alterations in PC. Thus, this MCSA project aims at elucidating the role of the SWI/SNF chromatin-remodeling complex in the emergence of resistance to anti-AR signaling inhibitors. This is of utmost importance as resistance to AR signaling inhibition is arguably the principle hallmark of lethal prostate cancer. To this end, I aim at (i) investigating the SWI/SNF dependent chromatin accessibility and AR cistrome; and at (ii) assessing the actionability of SWI/SNF interacting partners in castration resistance prostate cancer (CRPC). In short, this MSCA proposal will help to define the repertoire of SWI/SNF coregulators in CRPC and to determine the extent of AR cistrome remodeling to envision new therapeutic strategies and help predict treatment response.
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The information about "REGARCIS" are provided by the European Opendata Portal: CORDIS opendata.
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