Opendata, web and dolomites

GAMBBa SIGNED

Gene-activated AntiMicrobial Biomaterials for Bone regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 GAMBBa project word cloud

Explore the words cloud of the GAMBBa project. It provides you a very rough idea of what is the project "GAMBBa" about.

sustained    bioglasses       skills    modern    alexander    significantly    antimicrobial    activated    antibiotic    treatment    bone    plan    ions    proven    osteomyelitis    medicine    profile    boccaccini    acquiring    antagomir    healing    universit    capacity    independent    metal    dna    mature    competences    tissue    auml    eliminate    engineering    infection    entrepreneurship    bioactive    supervised    erlangen    devastating    functionalised    osteogenic    globally    me    technologies    environment    career    pbmp    dual    nanohydroxyapatite    nanoparticles    alternative    133a    repair    attempting    personal    complication    friedrich    prof    uuml    fellowship    osteoconductive    bacterial    combining    college    enhancement    collagen    antibiotics    plasmid    alarming    brien    complementary    combined    royal    regarded    simultaneously    clinical    resistance    action    leadership    tackles    commercialisation    pioneered    ireland    group    surgeons    scientist    incorporation    genetic    regeneration    achievement    innovative    scaffolds    microrna    diligently    cargoes    guided    profs    biomaterial    lab    defects    gene    professional    competitiveness    regenerative    visibility    rnberg   

Project "GAMBBa" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 184˙590.00

Map

 Project objective

Osteomyelitis, i.e. bone infection, combined with the alarming rise in antibiotic resistance globally, is currently regarded as the most devastating clinical complication when attempting to repair bone defects. This project tackles these major challenges of modern bone tissue engineering by developing a novel technology with dual osteogenic and antimicrobial action i.e. regenerative scaffolds that can eliminate bacterial infection while simultaneously providing a bioactive environment for bone growth. The specific goal of this research proposal is to develop and evaluate a new, innovative and effective treatment for osteomyelitis by combining non-antibiotic antimicrobial nanoparticles with gene-activated scaffolds for bone regeneration. Osteoconductive collagen-nanohydroxyapatite scaffolds with proven bone-healing potential will be functionalised for the sustained delivery of genetic cargoes to improve tissue repair, i.e. plasmid DNA (pBMP-2) and microRNA (antagomiR-133a), using novel technologies pioneered at Prof O’Brien’s Lab in the Royal College of Surgeons in Ireland. The project will also study the incorporation of metal-ions, an innovative alternative to traditional antibiotics, into scaffolds and bioglasses developed at Prof Boccaccini’s Lab at Friedrich-Alexander-Universität Erlangen-Nürnberg. Diligently supervised by Profs. O’Brien and Boccaccini, and guided by a Personal Career Development Plan, I will develop complementary skills in project management, entrepreneurship, commercialisation, leadership and profile enhancement. Acquiring advanced research competences and complementary skills will allow me to mature as an independent scientist, enhancing my professional visibility, capacity and competitiveness in the field of regenerative medicine. This Fellowship will significantly contribute to the achievement of my long-term career goal, which is becoming an independent scientist leading my own group focused on novel biomaterial research and development.

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The information about "GAMBBA" are provided by the European Opendata Portal: CORDIS opendata.

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