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GAMBBa SIGNED

Gene-activated AntiMicrobial Biomaterials for Bone regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 GAMBBa project word cloud

Explore the words cloud of the GAMBBa project. It provides you a very rough idea of what is the project "GAMBBa" about.

gene    professional    leadership    complementary    group    antibiotic    competences    profs    tissue    mature    proven    osteogenic    bioactive    action    nanohydroxyapatite    profile    significantly    supervised    metal    guided    capacity    antibiotics    osteoconductive    osteomyelitis    plasmid    resistance    alarming    antagomir    auml    attempting    simultaneously    healing    bone    competitiveness    combining    ions    uuml    regarded    lab    functionalised    independent    me    clinical    erlangen    dual    nanoparticles    surgeons    complication    prof    royal    achievement    friedrich    scaffolds    alternative    combined    engineering    bacterial    regeneration    microrna    sustained    college    entrepreneurship    medicine    universit    enhancement    boccaccini    innovative    acquiring    diligently    globally    activated    repair    treatment    incorporation    eliminate    collagen    technologies    modern    environment    skills    brien    cargoes    biomaterial    regenerative    rnberg    devastating       bioglasses    antimicrobial    alexander    infection    pbmp    plan    visibility    dna    scientist    ireland    pioneered    defects    fellowship    personal    genetic    career    133a    tackles    commercialisation   

Project "GAMBBa" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 184˙590.00

Map

 Project objective

Osteomyelitis, i.e. bone infection, combined with the alarming rise in antibiotic resistance globally, is currently regarded as the most devastating clinical complication when attempting to repair bone defects. This project tackles these major challenges of modern bone tissue engineering by developing a novel technology with dual osteogenic and antimicrobial action i.e. regenerative scaffolds that can eliminate bacterial infection while simultaneously providing a bioactive environment for bone growth. The specific goal of this research proposal is to develop and evaluate a new, innovative and effective treatment for osteomyelitis by combining non-antibiotic antimicrobial nanoparticles with gene-activated scaffolds for bone regeneration. Osteoconductive collagen-nanohydroxyapatite scaffolds with proven bone-healing potential will be functionalised for the sustained delivery of genetic cargoes to improve tissue repair, i.e. plasmid DNA (pBMP-2) and microRNA (antagomiR-133a), using novel technologies pioneered at Prof O’Brien’s Lab in the Royal College of Surgeons in Ireland. The project will also study the incorporation of metal-ions, an innovative alternative to traditional antibiotics, into scaffolds and bioglasses developed at Prof Boccaccini’s Lab at Friedrich-Alexander-Universität Erlangen-Nürnberg. Diligently supervised by Profs. O’Brien and Boccaccini, and guided by a Personal Career Development Plan, I will develop complementary skills in project management, entrepreneurship, commercialisation, leadership and profile enhancement. Acquiring advanced research competences and complementary skills will allow me to mature as an independent scientist, enhancing my professional visibility, capacity and competitiveness in the field of regenerative medicine. This Fellowship will significantly contribute to the achievement of my long-term career goal, which is becoming an independent scientist leading my own group focused on novel biomaterial research and development.

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The information about "GAMBBA" are provided by the European Opendata Portal: CORDIS opendata.

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