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GAMBBa SIGNED

Gene-activated AntiMicrobial Biomaterials for Bone regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 GAMBBa project word cloud

Explore the words cloud of the GAMBBa project. It provides you a very rough idea of what is the project "GAMBBa" about.

environment    lab    bioglasses    acquiring    alexander    competitiveness    skills    alternative    technologies    mature    universit    combining    prof    genetic    simultaneously    dual    significantly    complementary    ions    medicine    antibiotics    tissue    innovative    proven    nanoparticles    healing    tackles    profs    dna    eliminate    supervised       clinical    me    guided    sustained    profile    fellowship    competences    cargoes    microrna    pioneered    diligently    uuml    osteomyelitis    regenerative    attempting    antibiotic    antimicrobial    devastating    metal    scaffolds    bacterial    infection    enhancement    auml    nanohydroxyapatite    bone    modern    visibility    incorporation    royal    action    brien    pbmp    regarded    antagomir    surgeons    ireland    boccaccini    professional    alarming    osteogenic    resistance    133a    osteoconductive    biomaterial    career    entrepreneurship    scientist    rnberg    regeneration    group    capacity    engineering    gene    defects    repair    collagen    globally    personal    combined    bioactive    activated    plan    commercialisation    treatment    functionalised    plasmid    erlangen    friedrich    independent    complication    leadership    college    achievement   

Project "GAMBBa" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 184˙590.00

Map

 Project objective

Osteomyelitis, i.e. bone infection, combined with the alarming rise in antibiotic resistance globally, is currently regarded as the most devastating clinical complication when attempting to repair bone defects. This project tackles these major challenges of modern bone tissue engineering by developing a novel technology with dual osteogenic and antimicrobial action i.e. regenerative scaffolds that can eliminate bacterial infection while simultaneously providing a bioactive environment for bone growth. The specific goal of this research proposal is to develop and evaluate a new, innovative and effective treatment for osteomyelitis by combining non-antibiotic antimicrobial nanoparticles with gene-activated scaffolds for bone regeneration. Osteoconductive collagen-nanohydroxyapatite scaffolds with proven bone-healing potential will be functionalised for the sustained delivery of genetic cargoes to improve tissue repair, i.e. plasmid DNA (pBMP-2) and microRNA (antagomiR-133a), using novel technologies pioneered at Prof O’Brien’s Lab in the Royal College of Surgeons in Ireland. The project will also study the incorporation of metal-ions, an innovative alternative to traditional antibiotics, into scaffolds and bioglasses developed at Prof Boccaccini’s Lab at Friedrich-Alexander-Universität Erlangen-Nürnberg. Diligently supervised by Profs. O’Brien and Boccaccini, and guided by a Personal Career Development Plan, I will develop complementary skills in project management, entrepreneurship, commercialisation, leadership and profile enhancement. Acquiring advanced research competences and complementary skills will allow me to mature as an independent scientist, enhancing my professional visibility, capacity and competitiveness in the field of regenerative medicine. This Fellowship will significantly contribute to the achievement of my long-term career goal, which is becoming an independent scientist leading my own group focused on novel biomaterial research and development.

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The information about "GAMBBA" are provided by the European Opendata Portal: CORDIS opendata.

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