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GAMBBa SIGNED

Gene-activated AntiMicrobial Biomaterials for Bone regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 GAMBBa project word cloud

Explore the words cloud of the GAMBBa project. It provides you a very rough idea of what is the project "GAMBBa" about.

attempting    gene    osteomyelitis    me    dna    uuml    antimicrobial    nanoparticles    alexander    plasmid    sustained    regenerative    entrepreneurship    environment    medicine    technologies    simultaneously    nanohydroxyapatite    tissue    antibiotics    capacity    rnberg    bone    career    resistance    regarded    skills    combining    universit    scaffolds    biomaterial    college    guided    scientist    modern    osteoconductive    profile    repair    clinical    friedrich    commercialisation    ireland    complication    treatment    devastating    acquiring    profs    cargoes    personal    fellowship    professional    competitiveness    surgeons    healing    proven    regeneration    bioactive    achievement    visibility    functionalised    group    metal    ions    incorporation    microrna    alarming    innovative    brien    133a    complementary    infection    bacterial    significantly    genetic    diligently    competences    eliminate    plan    dual    pbmp    bioglasses    mature    supervised    tackles    erlangen    independent    engineering    boccaccini    combined    leadership    lab    action    defects    osteogenic    antagomir    antibiotic    globally       activated    collagen    enhancement    auml    prof    pioneered    alternative    royal   

Project "GAMBBa" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 184˙590.00

Map

 Project objective

Osteomyelitis, i.e. bone infection, combined with the alarming rise in antibiotic resistance globally, is currently regarded as the most devastating clinical complication when attempting to repair bone defects. This project tackles these major challenges of modern bone tissue engineering by developing a novel technology with dual osteogenic and antimicrobial action i.e. regenerative scaffolds that can eliminate bacterial infection while simultaneously providing a bioactive environment for bone growth. The specific goal of this research proposal is to develop and evaluate a new, innovative and effective treatment for osteomyelitis by combining non-antibiotic antimicrobial nanoparticles with gene-activated scaffolds for bone regeneration. Osteoconductive collagen-nanohydroxyapatite scaffolds with proven bone-healing potential will be functionalised for the sustained delivery of genetic cargoes to improve tissue repair, i.e. plasmid DNA (pBMP-2) and microRNA (antagomiR-133a), using novel technologies pioneered at Prof O’Brien’s Lab in the Royal College of Surgeons in Ireland. The project will also study the incorporation of metal-ions, an innovative alternative to traditional antibiotics, into scaffolds and bioglasses developed at Prof Boccaccini’s Lab at Friedrich-Alexander-Universität Erlangen-Nürnberg. Diligently supervised by Profs. O’Brien and Boccaccini, and guided by a Personal Career Development Plan, I will develop complementary skills in project management, entrepreneurship, commercialisation, leadership and profile enhancement. Acquiring advanced research competences and complementary skills will allow me to mature as an independent scientist, enhancing my professional visibility, capacity and competitiveness in the field of regenerative medicine. This Fellowship will significantly contribute to the achievement of my long-term career goal, which is becoming an independent scientist leading my own group focused on novel biomaterial research and development.

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The information about "GAMBBA" are provided by the European Opendata Portal: CORDIS opendata.

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