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GAMBBa SIGNED

Gene-activated AntiMicrobial Biomaterials for Bone regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 GAMBBa project word cloud

Explore the words cloud of the GAMBBa project. It provides you a very rough idea of what is the project "GAMBBa" about.

technologies    regarded    plasmid    diligently    globally    leadership    group    engineering    mature    scientist    friedrich    universit    guided    pioneered    treatment    college    auml    royal    regeneration    competitiveness    bone    innovative    modern    tackles    complication    bioactive    collagen    career    enhancement    alarming    professional    healing    nanohydroxyapatite    antibiotic    biomaterial    commercialisation    prof    alexander    medicine    cargoes    ions    scaffolds    dna    regenerative    bacterial    gene    resistance    osteoconductive    uuml    combined    surgeons    incorporation    capacity    profile    dual    antimicrobial    genetic    osteomyelitis    combining    skills    microrna    environment    attempting    independent    significantly    activated    eliminate    rnberg    repair    complementary    me    brien    osteogenic    simultaneously    personal    visibility    nanoparticles    sustained    entrepreneurship    pbmp    clinical    metal    lab    infection    proven    devastating       defects    supervised    tissue    competences    achievement    ireland    action    133a    alternative    erlangen    functionalised    profs    acquiring    plan    fellowship    bioglasses    antagomir    antibiotics    boccaccini   

Project "GAMBBa" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 184˙590.00

Map

 Project objective

Osteomyelitis, i.e. bone infection, combined with the alarming rise in antibiotic resistance globally, is currently regarded as the most devastating clinical complication when attempting to repair bone defects. This project tackles these major challenges of modern bone tissue engineering by developing a novel technology with dual osteogenic and antimicrobial action i.e. regenerative scaffolds that can eliminate bacterial infection while simultaneously providing a bioactive environment for bone growth. The specific goal of this research proposal is to develop and evaluate a new, innovative and effective treatment for osteomyelitis by combining non-antibiotic antimicrobial nanoparticles with gene-activated scaffolds for bone regeneration. Osteoconductive collagen-nanohydroxyapatite scaffolds with proven bone-healing potential will be functionalised for the sustained delivery of genetic cargoes to improve tissue repair, i.e. plasmid DNA (pBMP-2) and microRNA (antagomiR-133a), using novel technologies pioneered at Prof O’Brien’s Lab in the Royal College of Surgeons in Ireland. The project will also study the incorporation of metal-ions, an innovative alternative to traditional antibiotics, into scaffolds and bioglasses developed at Prof Boccaccini’s Lab at Friedrich-Alexander-Universität Erlangen-Nürnberg. Diligently supervised by Profs. O’Brien and Boccaccini, and guided by a Personal Career Development Plan, I will develop complementary skills in project management, entrepreneurship, commercialisation, leadership and profile enhancement. Acquiring advanced research competences and complementary skills will allow me to mature as an independent scientist, enhancing my professional visibility, capacity and competitiveness in the field of regenerative medicine. This Fellowship will significantly contribute to the achievement of my long-term career goal, which is becoming an independent scientist leading my own group focused on novel biomaterial research and development.

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The information about "GAMBBA" are provided by the European Opendata Portal: CORDIS opendata.

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