Explore the words cloud of the InProSMod project. It provides you a very rough idea of what is the project "InProSMod" about.
The following table provides information about the project.
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
|Coordinator Country||France [FR]|
|Total cost||184˙707 €|
|EC max contribution||184˙707 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2021-09-01 to 2023-08-31|
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|1||INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE||FR (PARIS)||coordinator||184˙707.00|
In the sensory cortex of awake mice, spontaneous activity has been shown to exhibit various regimes, characterized by various levels of spiking activity. Such diverse activity regimes, termed network states, have a profound impact on the computational properties during sensory processing. In the mouse barrel cortex, a major top-down pathway modulating sensory input is represented by the integration of inputs from the motor cortex and associative thalamus onto layer 1 (L1). Here I will characterize the synaptic and circuit properties underlying top-down control of sensory network states during whisking in L1. Using a combination of synaptic biophysics, in vivo electrophysiology, 2-photon imaging and theoretical modeling, I will define the important role of L1 interneurons in decoding top-down processing of sensory information. This research will generate valuable information to advance our knowledge of cortical circuit dynamics during normal cortical operations, with crucial implications for several brain disorders.
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