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BioMaGic SIGNED

Design of biomaterials with enzymatic logic gates

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BioMaGic project word cloud

Explore the words cloud of the BioMaGic project. It provides you a very rough idea of what is the project "BioMaGic" about.

clinical    takes    gates    network    assembled    prepare    implantable    economic    signals    eindhoven    mimicking    scientific    transferable    receive    expertise    add    tissues    materials    logic    establishing    career    logically    dimension    infection    competences    healthcare    constructs    faculty    outputs    biomaterial    skills    incoming    realized    serve    applicability    emerge    bacterial    coatings    tissue    biomagic    international    building    cascades    researcher    particles    hydrogel    enhancement    carry    class    academic    surfaces    reactions    fellowship    introduce    multiple    harness    blocks    return    enzymatically    line    input    harvard    strategy    biomaterials    autonomous    dynamic    interests    envisioned    bio    enzymatic    elicit    university    active    initiate    natural    dimensional    regeneration    biocatalytic    illustrate    additional    respectively    therapeutic    virtually    signaling    biochemical    basis    independent    outgoing    expanded    science    combinations   

Project "BioMaGic" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 253˙052 €
 EC max contribution 253˙052 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-GF
 Starting year 2021
 Duration (year-month-day) from 2021-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 253˙052.00
2    PRESIDENT AND FELLOWS OF HARVARD COLLEGE US (CAMBRIDGE) partner 0.00

Map

 Project objective

The present proposal takes a novel approach to design biomaterials with enzymatic logic gates. By mimicking enzymatic biocatalytic cascades present in natural tissues, these biomaterials will be able to receive and process multiple biochemical signals, and logically elicit therapeutic outputs in response to specific combinations of input signals. This goal will be realized using enzymatically active hydrogel particles (Specific Objective (SO) 1) as building blocks that will be assembled into biomaterial coatings (SO 2) or three-dimensional constructs (SO 3), which can be applied to surfaces of currently available biomaterials or serve as autonomous implantable biomaterials, respectively. To illustrate the wide applicability of this biomaterial design strategy, two major clinical challenges are selected as target applications, i.e., tissue regeneration and bacterial infection. The fellowship will harness the existing experience of the researcher in (bio)materials science, and will add a new dimension to this expertise in terms of biochemical signaling and enzymatic reactions. To achieve this goal, the researcher will carry out the outgoing phase of this fellowship at Harvard University, and then return to Eindhoven University of Technology for the incoming phase. The envisioned activities described in the proposal will prepare the researcher to emerge from this fellowship with additional scientific competences and transferable skills, and to establish an expanded international network. The success in this project will introduce a new class of biomaterials with dynamic signaling capabilities to elicit logic-based therapeutic effects, which can impact virtually all fields in which biomaterials are used, contributing to the enhancement of EU healthcare and economic interests. Through BioMaGic, the researcher will initiate an independent line of research as the basis for establishing an academic faculty career at a European research university.

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The information about "BIOMAGIC" are provided by the European Opendata Portal: CORDIS opendata.

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