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NeuroVascOme SIGNED

Gut microbiota-Neurovascular Interactions in Early Life

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NeuroVascOme project word cloud

Explore the words cloud of the NeuroVascOme project. It provides you a very rough idea of what is the project "NeuroVascOme" about.

industry    mental    linked    autism    strengthen    training    bbb    public    fellowships    vital    deficits    skillset    deficit    antibiotic    vulnerable    resident    day    disruptions    administration    stress    microbiome    perturbations    scientific    professional    caused    gateway    health    milieu    phases    sensitive    concomitant    maturation    microbial    link    mechanistic    environment    first    ing    neurovascome    managerial    neurovascular    altered    prevalent    disorder    microbiota    prenatal    composition    disorders    hyperactivity    regulating    predisposing    additionally    life    settings    outcomes    precisely    later    adverse    external    leads    turn    impacting    period    network    informed    society    audiences    alteration    occurs    accordance    function    homeostasis    disruptors    modern    organism    caesarean    brain    barrier    neurodevelopmental    postnatal    msca    rate    blood    shown    shaping    thereby    integrity    career    strategy    exact    academic    dysfunction    gut    aid   

Project "NeuroVascOme" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 196˙590.00

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 Project objective

The prenatal and early postnatal life are particularly vulnerable phases for brain development, during which essential neurodevelopmental processes occur. One such vital process is the development of the neurovascular unit resulting in the formation of blood brain barrier (BBB), which is the gateway regulating access of the external milieu to the brain. Concomitant with the postnatal BBB development, the maturation of our resident gut microbiota also occurs during this sensitive period of early life. Altered gut microbial composition has been shown to affect BBB function and is increasingly being linked to adverse health outcomes including neurodevelopmental disorders, such as autism or attention deficit hyperactivity disorder. However, an exact mechanistic understanding of how this early life alteration in microbiota composition leads to brain dysfunction is not known. The NeuroVascOme project aims to investigate the link between early life microbiota perturbations and neurovascular development, which in turn is crucial for brain homeostasis. And more precisely, how are the different disruptors of microbiome in early life impacting the neurovascular/BBB integrity, thereby predisposing the organism to health deficits in later life. This is especially relevant for our modern-day society wherein early life microbiome disruptions caused by increased stress, antibiotic administration and caesarean delivery methods are widely prevalent. In accordance with the aims of the MSCA fellowships, NeuroVascOme project will greatly aid my career development by providing first rate training in academic and industry settings that will enhance my research skillset, foster my managerial abilities and strengthen my professional network. Additionally, public, industry, and scientific audiences will be informed about the outcomes of the project through a dissemination strategy that will aim to promote the role of early life environment in shaping mental health.

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The information about "NEUROVASCOME" are provided by the European Opendata Portal: CORDIS opendata.

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