EUROCLAST
Exploring Functional and Developmental Osteoclast Heterogeneity in Health and Disease
| Coordinatore | STICHTING VU-VUMC
Organization address
address: DE BOELELAAN 1105 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Totale costo | 3˙135˙351 € |
| EC contributo | 3˙135˙351 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2013-ITN |
| Funding Scheme | MC-ITN |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-09-01 - 2017-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
STICHTING VU-VUMC
Organization address
address: DE BOELELAAN 1105 contact info |
NL (AMSTERDAM) | coordinator | 746˙011.44 |
| 2 |
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
Organization address
address: KING'S COLLEGE REGENT WALK contact info |
UK (ABERDEEN) | participant | 604˙213.25 |
| 3 |
NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S
Organization address
address: Herlev Hovedgade 207 contact info |
DK (Helev) | participant | 290˙079.47 |
| 4 |
TURUN YLIOPISTO
Organization address
address: YLIOPISTONMAKI contact info |
FI (TURUN YLIOPISTO) | participant | 266˙697.62 |
| 5 |
GOETEBORGS UNIVERSITET
Organization address
address: VASAPARKEN contact info |
SE (GOETEBORG) | participant | 265˙425.16 |
| 6 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 265˙425.16 |
| 7 |
FUTURE DIAGNOSTICS BV
Organization address
address: NIEUWEWEG 279 contact info |
NL (Wijchen) | participant | 242˙361.45 |
| 8 |
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Organization address
address: OLSHAUSENSTRASSE 40 contact info |
DE (KIEL) | participant | 227˙568.88 |
| 9 |
TECHNISCHE UNIVERSITAET DRESDEN
Organization address
address: HELMHOLTZSTRASSE 10 contact info |
DE (DRESDEN) | participant | 227˙568.88 |
Mappa
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Obiettivo del progetto (Objective)
'Euroclast proposes a research training program on osteoclast biology in the context of osteoclast-driven diseases. Osteoclasts are the complex, multinuclear cells responsible for bone breakdown. Many diseases of osteoclast malfunctioning manifest in bone loss, for example, osteoporosis, cancer-induced bone disease, periodontitis, or rheumatoid arthritis, all conditions set to increase in an ageing EU population. The Euroclast consortium (7 academic, 2 private and 1 ass. partner) focuses on osteoclast heterogeneity, a recent insight that poses new fundamental questions best tackled by a multi-partner consortium capable of assembling the sophisticated molecular, genetic and imaging tools required. We will analyze changes in gene and protein expression during osteoclast (trans)differentiation from different precursor cell pools and in various bone sites and relate this to osteoclast activity and sensitivity to therapeutics. The osteoclast resorptive apparatus will be studied using in depth and will define the key enzymatic and molecular machinery to be translated into novel site-specific drug targets or biomarkers. High throughput screening assays for therapeutics and ELISAs for biomarkers will be developed with our private partners. Our multidisciplinary and cross-sectorial approach will improve understanding and treatment of common disorders associated with osteoclast malfunction and train 11 early stage researchers (ESRs) in modern cell and bone biology. We will provide extensive training in generic skills and all ESRs will spend time with our private partners and be seconded to other academic partners to ensure they are well equipped for employment in research and industrial settings. Euroclast will produce an on-line repository for osteoclast protocols, make methodological and scientific advances in osteoclast and bone biology and create a sustainable network of ESRs and senior academics to tackle diseases of bone loss into the future.'