METACLOCK

Metabolic oscillations and the 24 hour (circadian) clockwork

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	1˙998˙056 €
EC contributo	1˙998˙056 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-StG_20101109
Funding Scheme	ERC-SG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-10-01   -   2016-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Dr. Nome: Akhilesh Cognome: Basi Reddy Email: send email Telefono: +44 1223 769038	UK (CAMBRIDGE)	hostInstitution	1˙998˙056.00
2	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333543 Fax: +44 1223 333543	UK (CAMBRIDGE)	hostInstitution	1˙998˙056.00

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 Obiettivo del progetto (Objective)

'We live in a '24 hour' culture, with transatlantic air travel and shift-work being part of normal life for many people. These types of desynchronisations (e.g. “jet-lag”) disrupt our daily physiology and are increasingly being linked to diseases such as diabetes, obesity and cancer. Daily rhythms are also impaired in the elderly, and in patients with common neurodegenerative conditions such as Alzheimer-type and fronto-temporal dementias, meaning that clock disruption is widespread in modern society. We know that every cell in the body has its own molecular clock, allowing it to coordinate its daily activities accurately, just as we would use a clock in our daily lives. Our work has uncovered novel mechanisms about how this works and how this fundamental timing system may have evolved in primitive single-celled organisms. By understanding these basic cellular mechanisms in greater detail, we anticipate that we will gain insights into how metabolic oscillations in each cell contribute to normal physiology and therefore disease.'