MEMBRANEATTACK

Molecular and cellular imaging of membrane interactions in pathogen attack and immune defense

 Coordinatore BIRKBECK COLLEGE - UNIVERSITY OF LONDON 

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 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 2˙311˙036 €
 EC contributo 2˙311˙036 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2011-ADG_20110310
 Funding Scheme ERC-AG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-06-01   -   2017-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    BIRKBECK COLLEGE - UNIVERSITY OF LONDON

 Organization address address: Malet Street
city: LONDON
postcode: WC1E 7HX

contact info
Titolo: Mr.
Nome: Juan
Cognome: Vidal
Email: send email
Telefono: +44 207 380 3141
Fax: +44 20 7380 3221

UK (LONDON) hostInstitution 2˙311˙036.00
2    BIRKBECK COLLEGE - UNIVERSITY OF LONDON

 Organization address address: Malet Street
city: LONDON
postcode: WC1E 7HX

contact info
Titolo: Prof.
Nome: Helen
Cognome: Saibil
Email: send email
Telefono: +44 207 631 6820
Fax: +44 207 631 6803

UK (LONDON) hostInstitution 2˙311˙036.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

pore    toxoplasma    molecular    cell    attack    protein    immune    pathogenesis    cellular    proteins    fundamental    actions    membrane    perforin    cells    microscopy    forming   

 Obiettivo del progetto (Objective)

'The immune system and pathogens both use membrane pore-forming proteins to penetrate cellular membranes, in order to kill target cells or to allow passage of pathogenic organisms such as malaria parasites, listeria, or toxoplasma. For both fundamental and practical reasons, it is important to understand the biological actions of the 'arms race' underlying virulence, pathogenesis and immune defense. The key weapon in this membrane attack is a class of proteins that upon activation undergo a dramatic conversion from water-soluble monomers to a large, membrane-inserted assembly. Both the human immune response and microbial pathogenesis rely on membrane disruption by perforin-like proteins for attack and counterattack. This protein superfamily encompasses perforin and complement pore-forming assemblies in the immune system, as well as the more distantly related bacterial cholesterol-dependent cytolysins. With recent advances in electron cryo-microscopy, tomography and correlative fluorescence microscopy, it is now possible to relate the workings of protein machines in model systems such as liposomes to their actions in the cellular context. I wish to capitalize on these technical advances and visualize membrane interactions at the moment the intracellular pathogen Toxoplasma gondii bursts out of its host cell, as well as the delivery of lethal cargo from the cytotoxic lymphocyte to its target cell through the immune synapse. These studies will correlate 3D spatial information at cellular and molecular levels to reveal the operation of dynamic cellular machinery. I have chosen a well-ordered system that can bridge the gulf between cell biology and atomic structure. Innovations in sample preparation combined with state-of the art imaging methods will lead to the molecular definition of a fundamental process in “hostile” communication between cells and will broaden the landscape for drug design for immune disorders and major infectious diseases.'

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