TUBEREMODELLING

"Tubular organ remodelling during development, homeostasis and disease"

 Coordinatore UNIVERSITY OF CYPRUS 

 Organization address address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678

contact info
Titolo: Prof.
Nome: Niovi
Cognome: Santama
Email: send email
Telefono: +357 22392757

 Nazionalità Coordinatore Cyprus [CY]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-04-01   -   2016-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS

 Organization address address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678

contact info
Titolo: Prof.
Nome: Niovi
Cognome: Santama
Email: send email
Telefono: +357 22392757

CY (NICOSIA) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

signalling    mammalian    progenitors    vessels    lungs    trachea    tumorigenesis    aim    network    homeostasis    cell    tubular    proliferation    remodelling    differentiation    drosophila    angiogenesis    cellular    developmental    tracheal    disease    blood    adult    model    intestinal    tube    organs    remodelled   

 Obiettivo del progetto (Objective)

'Remodelling of tubular organs, like the lungs or blood vessels, encompasses the changes in both cell number and cell shape that lead to an altered organ form adapted to changes in developmental timing, injury or environmental cues. To understand how tubular organs are remodelled during development and disease, I will use as a model the Drosophila tracheal system, which is an extensive tubular network that functions as the lungs and blood vessels. Moreover, the similarity of the fly trachea with mammalian tubular organs extends to the cellular and molecular levels of tube formation, making findings in Drosophila applicable to mammalian biology. To study developmental remodelling, I characterized a set of multipotent progenitors, which respond to evolutionarily-conserved signals that coordinate cellular proliferation and differentiation to generate anew the tracheal system of the adult. In addition, I established in adult Drosophila an intestinal infection and tumorigenesis model. Strikingly, in this model the trachea that surrounds and oxygenates the diseased gut is extensively remodelled, sharing parallels with mammalian angiogenesis. By combining my knowledge of tracheal development and intestinal homeostasis, I aim to understand how signalling pathways interact to remodel epithelial tubular organs during development and disease. Understanding how tubular organs are formed and remodelled in a genetically-amenable model system like Drosophila will aid our understanding of the cause of developmental anomalies and diseases of tubular organs like dysplasias, polycystic kidney disease and tumor angiogenesis. Specifically, I will: Aim 1: Characterize the signalling network that coordinates proliferation and differentiation of tracheal progenitors during developmental remodelling. Aim 2: Identify novel molecules involved in tube remodelling during physiological and regenerative homeostasis as well as during tumorigenesis.'

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