GSCS MAINTENANCE

Post-transcriptional regulation of Germline Stem Cells (GSCs) maintenance

Coordinatore	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY    more  Organization address address: TECHNION CITY - SENATE BUILDING city: HAIFA postcode: 32000 contact info Titolo: Mr. Nome: Mark Cognome: Davison Email: send email Telefono: +972 4 829 3097 Fax: +972 4 823 2958
Nazionalità Coordinatore	Israel [IL]
Totale costo	250˙106 €
EC contributo	250˙106 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IIF
Funding Scheme	MC-IIF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-05-01   -   2014-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY  Organization address address: TECHNION CITY - SENATE BUILDING city: HAIFA postcode: 32000 contact info Titolo: Mr. Nome: Mark Cognome: Davison Email: send email Telefono: +972 4 829 3097 Fax: +972 4 823 2958	IL (HAIFA)	coordinator	250˙106.00

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 Obiettivo del progetto (Objective)

'Adult stem cells (SCs), also known as tissue SCs, support tissue homeostasis and repair throughout the entire life of the organism. The remarkable longevity of tissue SCs relies on their unique ability to asymmetrically generate new SCs (self-renewal) as well as specialized cell types (differentiation). Notably, many genes that signal to regulate the balance between renewal and differentiation encode proteins as well as small RNA molecules, predicted to regulate specific mRNAs. This proposal is aimed to uncover RNA regulation networks essential for maintaining an adult germline stem cells (GSCs) pool, and for preventing differentiation along the germline lineage. Ultimately, I wish to understand in molecular details how the activities of diverse post-transcriptional factors are coordinated in space and time to give a functional tissue homeostasis. Using the Drosophila testis - a stem cell based tissue model in which stem cells and the niche have been defined and can be manipulated, I aim to investigate SCs regulation by conserved RNA regulators. To pursue these interests I will use a variety of biochemical and genetic assays in the highly genetically amenable model organism, Drosophila melanogaster. Given that tissue homeostasis and repair supported by adult SCs is a primordial mechanism of multicellular animals, I anticipate the functional importance of many of the genes to be identified will be conserved between flies and mammals. Understanding the mechanistic basis of adult SC self-renewal, as well as of regulating the differentiation and proliferation of their progeny, will ultimately facilitate stem cell based therapies for regenerative medicine including age-onset diseases and cancer.'

Introduzione (Teaser)

The interplay of stem cells with their microenvironment is of outmost importance for their function. Understanding how this interaction is regulated provides novel insight into fundamental aspects of tissue homeostasis.