MICROENCAPSDELIVERY

MicroEncapsDelivery

 Coordinatore "BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS" 

 Organization address address: Soranou Efesiou 4
city: ATHENS
postcode: 11527

contact info
Titolo: Mr.
Nome: Dimitris
Cognome: Raptis
Email: send email
Telefono: +30 210 6597574
Fax: 302107000000

 Nazionalità Coordinatore Greece [EL]
 Totale costo 161˙065 €
 EC contributo 161˙065 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-09-01   -   2014-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    "BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS"

 Organization address address: Soranou Efesiou 4
city: ATHENS
postcode: 11527

contact info
Titolo: Mr.
Nome: Dimitris
Cognome: Raptis
Email: send email
Telefono: +30 210 6597574
Fax: 302107000000

EL (ATHENS) coordinator 161˙065.20

Mappa

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 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

pex    worldwide    platform    liver    hcc    beads    hepatocellular    tace    carcinoma    cancer    il    drug    tumour    therapeutic    doxorubicin    released    primarily    systemic    treatment    death   

 Obiettivo del progetto (Objective)

'In this multidisciplinary research proposal we aim to develop a new therapeutic platform for hepatocellular carcinoma (HCC). HCC is the third leading cause of cancer death worldwide with a death rate greater than 600,000 persons annually. Currently the main curative treatments include resection, liver transplantation, or percutaneous local ablative treatment. However, all these approaches are primarily suitable for asymptomatic patients with very early and early HCCs. Transarterial chemoembolization (TACE) is the primarily indicated treatment for HCC. New evidence suggests that TACE with doxorubicin-eluting beads is superior to conventional TACE, in terms of reduced adverse event rates and improved survival. These beads are impregnated with doxorubicin, which is slowly released after being infused into the tumour vessels allowing a delivery of high intratumoral concentrations with a low serum doxorubicin level. Ideally, the injected chemotherapeutic should be retained in the tumor and be gradually released to avoid systemic toxicity. However, its selective injection is associated to significant passage into the systemic circulation. To improve drug delivery to the liver, the project “MicroEncapsDelivery” aims to develop a new therapeutic platform for the treatment of HCC that will deliver locally at the tumour the angiogenesis inhibitor hemopexin-like protein (PEX) and the immunostimulatory cytokine interleukin 12 (IL-12). This interdisciplinary therapeutic approach encompasses microencapsulation of genetically modified bone marrow derived mesenchymal stem cells, within biocompatible alginate beads, for the continuous and localised delivery of the therapeutic factors. Our goal is to develop the cell microcapsules and optimise and characterise the pharmacological profiles of PEX and IL-12 in vitro and their biodistribution in vivo in an established HCC rabbit animal model. The result will be dramatically reduced tumour in a manner that was unachievable until now.'

Introduzione (Teaser)

Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. An EU-funded project developed a new drug delivery system specifically for HCC treatment.

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