MODUCAT

New modular self-assembled homogeneous catalysts for asymmetric synthesis in water

 Coordinatore A.N. NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS OF RUSSIAN ACADEMY OF SCIENCES 

 Organization address address: VAVILOVA STREET 28
city: MOSCOW
postcode: 119991

contact info
Titolo: Prof.
Nome: Yuri
Cognome: Bubnov
Email: send email
Telefono: -1356658
Fax: -1350668

 Nazionalità Coordinatore Russian Federation [RU]
 Totale costo 15˙000 €
 EC contributo 15˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IIF-2008
 Funding Scheme MC-IIFR
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-06-18   -   2013-06-17

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    A.N. NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS OF RUSSIAN ACADEMY OF SCIENCES

 Organization address address: VAVILOVA STREET 28
city: MOSCOW
postcode: 119991

contact info
Titolo: Prof.
Nome: Yuri
Cognome: Bubnov
Email: send email
Telefono: -1356658
Fax: -1350668

RU (MOSCOW) coordinator 15˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

polar    compounds    responsible    catalysts    chiral    modular    enantioselectivity    reaction    molecules    tested    charged    optically    model    media    aqueous    expensive    units    catalyst    homogeneous    water    nps    asymmetric    moducat    selectivity    assembled    innovative    chemical    active    quot    catalysis    synthesis   

 Obiettivo del progetto (Objective)

'There is a continuous interest to apply homogeneous catalysis to asymmetric synthesis, which is the elective method for drugs production in pharmaceutical industry. Asymmetric catalysis provides the cheapest synthetic route to optically active compounds with minimal number of steps and reduced use of expensive chiral substrates. Replacing conventional methods with those involving asymmetric catalysis is then mandatory to reduce considerably energy/materials costs and the environmental impact of chemical manufacturing. The improvement of either efficiency and selectivity of traditional molecular chiral catalysts is a time consuming and expensive procedure that may be bypassed by the development of the innovative "modular catalysis" on which the MODUCAT proposal is concerning. The accomplishment of MODUCAT milestones will boost the application of asymmetric catalysts to several industrial processes. The main objectives of the project are: (1) to develop the modular assemblage of a chiral catalyst consisting of two independent units, separately responsible for activity and enantioselectivity. Such units, assembled together by Coulombic and/or hydrophobic forces, should form an innovative catalyst conjugating activity with enantioselectivity; (2) to validate the MODUCAT ideas in model catalytic asymmetric processes carried out in aqueous media. While the few known examples of "modular catalysts" find application in non-polar media, we propose to use Ag/Au NPs functionalized with SAMs of optically active charged molecules to bring about the modular approach in polar solvents. While the Fellow's background in catalysis, organometallic/colloidal chemistry, particularly dealing with charged NPs, is a big asset that guarantees high chance to reach the goals of the project, his training in preparation of water soluble catalysts and their application to aqueous systems, where the Host has a recognized experience, is a fundamental prerequisite for the success of the project.'

Introduzione (Teaser)

EU-funded researchers have developed a new modular type of catalyst that will make the synthesis of complex chemicals (such as pharmaceuticals) cheaper and quicker.

Descrizione progetto (Article)

Catalysis is a crucial part of modern chemical synthesis. Asymmetric catalysts are especially important as they help produce enantiomers (compounds that cannot be superimposed over their mirror images, like left and right hands).

The 'New modular self-assembled homogeneous catalysts for asymmetric synthesis in water' (MODUCAT) project aimed to produce a new class of modular catalysts. Researchers aimed to bond different catalysts responsible for activity and for enantio-selectivity into one catalyst that could perform both functions.

Researchers first tested gold nanoparticles with certain chemical groups attached. This approach was helpful in allowing them to model the process, but presented some problems in practice.

Next, they tested micelles (aggregated fat molecules, almost like bubbles) as these provided compartments that could contain other catalysts. These proved much more effective as modular catalysts, successfully catalysing the model reaction used in the MODUCAT project.

Further studies of this reaction helped researchers better understand the requirements for an effective modular catalyst. The MODUCAT project concluded that developing modular catalysts that function in an aqueous solution is a feasible goal and should be pursued for commercial application.

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