UNIQUE PRECURSOR

"Concise Synthesis of Tricyclic Angularly Fused Natural Products via Controlled Cyclizations of a Common Key Precursor: Preparation of Alliacanes, Arteannuins, Pentalenolactones and Triquinanes"

 Coordinatore THE HEBREW UNIVERSITY OF JERUSALEM. 

 Organization address address: GIVAT RAM CAMPUS
city: JERUSALEM
postcode: 91904

contact info
Titolo: Ms.
Nome: Hani
Cognome: Ben-Yehuda
Email: send email
Telefono: +972 2 6586618
Fax: +972 72 2447007

 Nazionalità Coordinatore Israel [IL]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-10-01   -   2016-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM.

 Organization address address: GIVAT RAM CAMPUS
city: JERUSALEM
postcode: 91904

contact info
Titolo: Ms.
Nome: Hani
Cognome: Ben-Yehuda
Email: send email
Telefono: +972 2 6586618
Fax: +972 72 2447007

IL (JERUSALEM) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

angularly    precursor    structures    accessible    tricyclic    natural    efficient    fused    synthetic    core    molecules   

 Obiettivo del progetto (Objective)

'A general and highly efficient diversity-oriented synthesis of tricyclic angularly fused-structured natural products, such as arteannuins, alliacanes, pentalenolactones and triquinanes, via selective cyclization from a common precursor is proposed. The outlined synthetic methodology offers conceptually novel perspective, enabling to deliver multiple targets via cascade sequence of controlled intramolecular reactions from a common easily accessible key precursor; thus, providing simplified access to numerous classes of natural products, pharmaceutically important molecules and new potential therapeutic agents and drug candidates. Apparently, the mere existence of similar fundamental core structures is not exclusive to chemical compounds extracted from the same natural source. Common or highly resembling core structures were identified throughout various forms of life, such as different (and often distantly related) families of plants, as well as corals, fungi and bacteria. Examples include modern drugs and natural products derived from a broad spectrum of biological sources, such as Alliacol A, Artemisinine, Pentalenolactone P, Arteannuin M, and many others that share the tricyclic angularly fused ring systems. Even though previously developed synthetic methodologies towards the construction of the above mentioned molecules exist, the generality of our strategy and the ability to utilize simple and readily accessible precursors, will uncover rapid and efficient synthetic pathways to result in a wide range of natural products.'

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