MEMBRANENANOPART

Modelling the mechanisms of nanoparticle-lipid interactions and nanoparticle effects on cell membrane structure and function

 Coordinatore UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

 Organization address address: BELFIELD
city: DUBLIN
postcode: 4

contact info
Titolo: Dr.
Nome: Vladimir
Cognome: Lobaskin
Email: send email
Telefono: +353 1 7162432

 Nazionalità Coordinatore Ireland [IE]
 Sito del progetto http://www.membranenanopart.eu
 Totale costo 1˙281˙035 €
 EC contributo 999˙810 €
 Programma FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
 Code Call FP7-NMP-2012-SMALL-6
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-01-01   -   2015-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

 Organization address address: BELFIELD
city: DUBLIN
postcode: 4

contact info
Titolo: Dr.
Nome: Vladimir
Cognome: Lobaskin
Email: send email
Telefono: +353 1 7162432

IE (DUBLIN) coordinator 355˙180.00
2    IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

 Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ

contact info
Titolo: Ms.
Nome: Brooke
Cognome: Alasya
Email: send email
Telefono: +44 207 594 1181

UK (LONDON) participant 299˙989.00
3    STOCKHOLMS UNIVERSITET

 Organization address address: Universitetsvaegen 10
city: STOCKHOLM
postcode: 10691

contact info
Titolo: Mr.
Nome: Daniel
Cognome: Emanuelsson
Email: send email
Telefono: +46 8 162374

SE (STOCKHOLM) participant 284˙095.00
4    INSTITUTE OF BIOLOGY OF KARELIAN RESARCH CENTRE RUSSIAN ACADEMY OF SCIENCES

 Organization address address: PUSHKINSKAYA STREET 11
city: PETROZAVODSK REPUBLIC OF KARELIA
postcode: 185910

contact info
Titolo: Prof.
Nome: Alexander
Cognome: Rabinovich
Email: send email
Telefono: +78 14 2769810

RU (PETROZAVODSK REPUBLIC OF KARELIA) participant 60˙546.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cell    protein    interactions    simulation    nps    nanoparticle    toxicological    dynamics    models    mechanisms    toxicity    engineered    nanoparticles    membrane    molecular    computational   

 Obiettivo del progetto (Objective)

'The central goal of our proposal is to develop physically justified models and computational tools to quantitatively describe and understand the molecular mechanisms of nanoparticle-cell membrane interactions, which we consider to be a crucial point in any predictive model of nanoparticle toxicity. We consider mechanisms of nanoparticle protein corona formation, the protective function of the membrane, nanoparticle uptake into the cell, and the effect of nanoparticles on the cell membrane. We plan to develop a consistent multiscale simulation scheme starting from nanoparticle-biomolecule interaction at the atomistic scale using molecular dynamics simulation, and then systematically constructing coarse-grained mesoscale models for simulating the structure and dynamics of the cell membrane perturbed by nanoparticles at the physiologically relevant time and length scales. We will develop and test a universal method for evaluating the rates of nanoparticle translocation through membranes and evaluate associated specific toxicity effects. Based on the information acquired from the simulations and analyzed together with available experimental data, the toxicological impact will be deduced. We will apply our approach to a range of common engineered nanoparticles, relating their physicochemical properties such as size and shape, surface charge, hydrophobicity (logP), and plasma protein binding affinity to the toxicological effects and develop a test suite allowing to make toxicity prediction on the basis of purely computational or limited in vitro screening tests.'

Introduzione (Teaser)

Engineered nanoparticles (NPs) are enabling miniaturisation and functionalisation of devices in numerous fields. New models of toxicity and interactions at the level of the cell membrane will foster design of NPs safe for people and the environment.

Altri progetti dello stesso programma (FP7-NMP)

NANOMAGDYE (2008)

MAGNETIC NANOPARTICLES COMBINED WITH SUBMICRONIC BUBBLES AND DYE FOR ONCOLOGING IMAGING

Read More  

SMILEY (2012)

Smart nano-structured devices hierarchically assembled by bio-mineralization processes

Read More  

NOVA-CI(G)S (2010)

Non-vacuum processes for deposition of CI(G)S active layer in PV cells

Read More