ARTHROPODSEGCLOCK

Investigating the Arthropod Segmentation Clock that controls Sequential Segment Formation during Arthropod Development and its Potentially Ancient Evolutionary Origins

 Coordinatore UNIVERSITY OF LEEDS 

 Organization address address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT

contact info
Titolo: Mr.
Nome: Martin
Cognome: Hamilton
Email: send email
Telefono: +44 113 343 4090
Fax: +44 113 343 0949

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-05-01   -   2017-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS

 Organization address address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT

contact info
Titolo: Mr.
Nome: Martin
Cognome: Hamilton
Email: send email
Telefono: +44 113 343 4090
Fax: +44 113 343 0949

UK (LEEDS) coordinator 100˙000.00

Mappa

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 Word cloud

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tribolium    segments    vertebrates    somites    molecular    clock    related    genes    evolutionary    clocks    arthropod    genetic    form    underlying    principles    determine    vertebrate    model    segmentation    body   

 Obiettivo del progetto (Objective)

'Many biological processes, with relevance to human development and disease, occur under the control of 'molecular clocks'. One such process is the rhythmical formation of somites during vertebrate embryogenesis. Somites are blocks of tissue that give rise to reiterated vertebrae and their associated muscle. The sequential formation of somites along the body axis of vertebrate embryos occurs via the activities of the vertebrate segmentation clock. My recent work has shown that the body units (segments) of an arthropod, the beetle Tribolium castaneum, also form via the activities of a segmentation clock. This finding suggests that vertebrate somites and arthropod segments form using similar developmental principles. Given the evolutionary distance separating vertebrates and arthropods this finding might also imply that a segmentation clock played an ancient and ancestral role in animal development. However, we have so far only identified two genes involved in the Tribolium clock, compared to 40-100 unrelated genes involved in the segmentation clocks of model vertebrates, making it too early to conclude that the arthropod and vertebrate segmentation clocks are evolutionarily related. I propose a series of genetic and genome-wide approaches to systematically test this idea. A novel, state-of-the-art, transcriptome screen will be used to determine the number and identity of genes involved in the Tribolium segmentation clock. Reverse genetic and transgenic approaches will be used to determine the regulatory interactions underlying the Tribolium clock. This constitutes an ambitious attempt to determine if the arthropod and vertebrate segmentation clocks are evolutionary related, knowledge that would have profound implications for our understanding of the evolution of all animals. It will also help establish Tribolium as a powerful invertebrate model for studying the principles underlying the activities of molecular clocks.'

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