DASCA

Direct Alkylation of Saturated Cyclic Amines via catalytic C-H Functionalization

Coordinatore	UNIVERSITEIT ANTWERPEN    more  Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 contact info Titolo: Mrs. Nome: Anne Cognome: Adams Email: send email Telefono: +32 3 265 30 28 Fax: +32 3 265 30 11
Nazionalità Coordinatore	Belgium [BE]
Totale costo	169˙800 €
EC contributo	169˙800 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IIF
Funding Scheme	MC-IIF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-03-01   -   2015-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITEIT ANTWERPEN  Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 contact info Titolo: Mrs. Nome: Anne Cognome: Adams Email: send email Telefono: +32 3 265 30 28 Fax: +32 3 265 30 11	BE (ANTWERPEN)	coordinator	169˙800.00

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 Obiettivo del progetto (Objective)

'Direct conversion of C-H into C-C bonds is arguably indispensable in modern organic chemistry, as it allows for obtaining target compounds which are otherwise only accessible via lengthy procedures involving multi-step synthesis. Catalytic C-H functionalization is the most attractive approach to achieve this goal, as it does not require stoichiometric amounts of activating reagent. This research proposal aims to develop direct transition metal-catalyzed functionalizations of C(sp3)–H bonds in saturated nitrogen-based heterocycles, with a particular focus on compatibility with a very broad range of functional groups, regioselectivity and stereoselectivity. Towards this goal, insertion reactions with substituted alkenes featuring a variety of functional groups will be explored. The development of such a technology offers an important contribution to novel, improved and more sustainable synthetic pathways and is expected to be highly warranted for drug discovery purposes.'