DNA REPLICATION

In vitro reconstitution of the replication machinery on a chromatin template

 Coordinatore THE FRANCIS CRICK INSTITUTE LIMITED 

 Organization address address: 215 Euston Road, Gibbs Building
city: LONDON
postcode: NW1 2BE

contact info
Titolo: Ms.
Nome: Heather Joanne
Cognome: Woods
Email: send email
Telefono: 442076000000

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 221˙606 €
 EC contributo 221˙606 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-06-01   -   2015-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED

 Organization address address: 215 Euston Road, Gibbs Building
city: LONDON
postcode: NW1 2BE

contact info
Titolo: Ms.
Nome: Heather Joanne
Cognome: Woods
Email: send email
Telefono: 442076000000

UK (LONDON) coordinator 221˙606.40
2    CANCER RESEARCH UK

 Organization address address: ST JOHN STREET 407 ANGEL BUILDING
city: LONDON
postcode: EC1V 4AD

contact info
Titolo: Ms.
Nome: Holly
Cognome: Elphinstone
Email: send email
Telefono: +44 207 269 3524
Fax: +44 207 269 3585

UK (LONDON) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

genome    duplication    nucleosomes    chromatin    cell    basic    replication    dna   

 Obiettivo del progetto (Objective)

'DNA replication, the process where the genetic material is duplicated, is one of the most important and basic processes a cell undertakes. It is essential that this process is tightly and carefully regulated as errors in DNA replication are catastrophic, resulting in diseases like cancer. The synthetic or S phase of the eukaryotic cell cycle is entirely devoted to genome duplication by orchestrating two processes: DNA replication and histone production. Histones are small basic proteins that together with the DNA form the nucleosome, the repetitive subunit of chromatin. Nucleosomes provide for save storage of linear DNA and contribute to genome integrity. However, nucleosomes are very stable which limits the access of underlying DNA and thus has inhibitory effects on DNA replication, gene expression and DNA repair. Although tremendous progress has been made in order to reveal the molecular mechanisms, clear gaps remain in our understanding of DNA replication biology. One of these important questions is how the replication machinery overcomes the chromatin barrier for efficient DNA duplication. The goal of this proposal is to shed light onto how DNA replication initiates and the replisome elongates on chromatin.'

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