|Coordinatore||KATHOLIEKE UNIVERSITEIT LEUVEN
address: Oude Markt 13
|Nazionalità Coordinatore||Belgium [BE]|
|Totale costo||177˙000 €|
|EC contributo||177˙000 €|
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
|Anno di inizio||2013|
|Periodo (anno-mese-giorno)||2013-05-01 - 2015-04-30|
KATHOLIEKE UNIVERSITEIT LEUVEN
address: Oude Markt 13
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'The skin is not only a barrier between our body and the environment, but also functions as a huge sensory ‘surface’, involved in sensing various stimuli, as well as in the etiology of itch and pain. As such, the skin can be envisaged as our largest (multi)sensory organ. Ion channels of the transient receptor potential (TRP) family are considered as cellular sensors, due to their sensitivity to various physical and diverse chemical stimuli, including endogenous mediators as well as various exogenous compounds. Multimodal nociceptive TRP channels are also appealing drug targets in pain-associated syndroms. TRPM3, a member of the melastatin subfamily of TRP channels, was recently reported as a novel neurosteroid- and thermosensitive channel in the pain pathway. In this project we aim to discover how the channel properties of TRPM3 are regulated at molecular and cellular levels, and how these regulatory mechanisms influence the channel’s versatile functions in normal sensory transduction and in processes such as itch and hyperalgesia. A wide array of techniques will be combined to investigate the influence of intracellular signaling pathways and the effect of various mediators (neurotransmitters, mediators of pain, itch and inflammation) on TRPM3 channel function and expression in recombinant systems and primary sensory neurons. The relevance of this novel neurosteroid sensor and its regulatory pathways on skin sensory functions will be analyzed in several functional assays at the organ and behavioral levels using transgenic animal models. This project is expected to reveal important new insight into the cutaneous sensory processes involving TRPM3, which may form the basis of novel therapeutic approaches to treat itch or pain. The execution of the project will widely extend the fellow`s knowledge, technical and complementary skills aiding to reach a position of professional maturity and significantly contributing to his career development in the European Research Area.'