TRPM3 IN SKIN

Cellular regulation of transient receptor potential melastatin 3 (TRPM3) and its role in skin sensation

 Coordinatore KATHOLIEKE UNIVERSITEIT LEUVEN 

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Dr.
Nome: Stijn
Cognome: Delauré
Email: send email
Telefono: +32 16 320 944
Fax: +32 16 324 198

 Nazionalità Coordinatore Belgium [BE]
 Totale costo 177˙000 €
 EC contributo 177˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-05-01   -   2015-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Dr.
Nome: Stijn
Cognome: Delauré
Email: send email
Telefono: +32 16 320 944
Fax: +32 16 324 198

BE (LEUVEN) coordinator 177˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

levels    cellular    skin    neurosteroid    channels    mediators    stimuli    regulatory    functions    trpm    pain    pathways    channel    trp    organ    influence    sensory    itch   

 Obiettivo del progetto (Objective)

'The skin is not only a barrier between our body and the environment, but also functions as a huge sensory ‘surface’, involved in sensing various stimuli, as well as in the etiology of itch and pain. As such, the skin can be envisaged as our largest (multi)sensory organ. Ion channels of the transient receptor potential (TRP) family are considered as cellular sensors, due to their sensitivity to various physical and diverse chemical stimuli, including endogenous mediators as well as various exogenous compounds. Multimodal nociceptive TRP channels are also appealing drug targets in pain-associated syndroms. TRPM3, a member of the melastatin subfamily of TRP channels, was recently reported as a novel neurosteroid- and thermosensitive channel in the pain pathway. In this project we aim to discover how the channel properties of TRPM3 are regulated at molecular and cellular levels, and how these regulatory mechanisms influence the channel’s versatile functions in normal sensory transduction and in processes such as itch and hyperalgesia. A wide array of techniques will be combined to investigate the influence of intracellular signaling pathways and the effect of various mediators (neurotransmitters, mediators of pain, itch and inflammation) on TRPM3 channel function and expression in recombinant systems and primary sensory neurons. The relevance of this novel neurosteroid sensor and its regulatory pathways on skin sensory functions will be analyzed in several functional assays at the organ and behavioral levels using transgenic animal models. This project is expected to reveal important new insight into the cutaneous sensory processes involving TRPM3, which may form the basis of novel therapeutic approaches to treat itch or pain. The execution of the project will widely extend the fellow`s knowledge, technical and complementary skills aiding to reach a position of professional maturity and significantly contributing to his career development in the European Research Area.'

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