T-BAC

Exploring the roles and plasticity of T-cell responses in anti-BACterial immunity

 Coordinatore GlaxoSmithKline Biologicals 

 Organization address address: Rue de l'Institut 89
city: Rixensart
postcode: 1330

contact info
Titolo: Dr.
Nome: Philippe
Cognome: Denoel
Email: send email
Telefono: 3226564032

 Nazionalità Coordinatore Belgium [BE]
 Totale costo 169˙800 €
 EC contributo 169˙800 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-05-01   -   2015-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    GlaxoSmithKline Biologicals

 Organization address address: Rue de l'Institut 89
city: Rixensart
postcode: 1330

contact info
Titolo: Dr.
Nome: Philippe
Cognome: Denoel
Email: send email
Telefono: 3226564032

BE (Rixensart) coordinator 169˙800.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cells    il    selected    functional    aureus    immunity    behavior    cytokine    bacterial    phenotypic    play    vaccine       cell    proteins    responses    profiles    antigens    plasticity    cd    inflammatory    anti    linked    vaccination    induce   

 Obiettivo del progetto (Objective)

'Antibodies against bacterial polysaccharides and proteins play a role in anti-bacterial immunity. To date, S. aureus vaccine candidates were selected to induce functional antibody responses. However, a potential role for T-cell mediated immunity is emerging, supported by the fact that impaired Th17 responses in patients with hyper IgE syndrome are linked to abnormal susceptibility to S. aureus infections. Thus, the capacity to induce specific T cell responses may be an important criterion to select vaccine antigens. Understanding the nature of anti-bacterial T cells and their behavior in steady state or under inflammatory conditions (eg, immunization) is thus important for the design of novel vaccine strategies against bacterial pathogens. Among CD4 T cells, Th17 cells play a pivotal role in mucosal host protection. These cells are mainly characterized by the production of the cytokine IL 17A but display considerable phenotypic plasticity. For S. aureus-specific Th17 cells, published data suggest a link between Th17 plasticity and the innate cytokine IL-1b, highlighting the need to better understand the functional role of the different Th17 subsets. Using S. aureus as a model, and hypothesizing that the functional profiles of CD4 T cells (Th1, Th17) may be linked to selected bacterial proteins, we first aim to identify specific S. aureus antigens with defined Th profiles in humans. Second, using in vitro stimulation methods, we aim to phenotypically characterize S. aureus-specific CD4 T cell responses induced by these proteins. Phenotypic plasticity and behavior will be studied under inflammatory (IL-1b, IL-6 or IL-23) cell culture conditions. Third, we aim to evaluate the impact of vaccination on the frequency, phenotype and plasticity of specific memory CD4 T cells, using samples from an S. aureus vaccine trial. This allows studying the phenotypes of antigen-specific CD4 T cells after in vivo exposure (vaccination) to antigens.'

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