THERACAV

Harnessing Cavitation for Therapy

 Coordinatore UNIVERSITY OF DUNDEE 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 1˙453˙180 €
 EC contributo 1˙453˙180 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-StG
 Funding Scheme ERC-SG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-10-01   -   2018-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY OF DUNDEE

 Organization address address: Nethergate
city: DUNDEE
postcode: DD1 4HN

contact info
Titolo: Dr.
Nome: Paul Alan
Cognome: Prentice
Email: send email
Telefono: 441382000000
Fax: 441382000000

UK (DUNDEE) hostInstitution 1˙453˙180.00
2    UNIVERSITY OF DUNDEE

 Organization address address: Nethergate
city: DUNDEE
postcode: DD1 4HN

contact info
Titolo: Ms.
Nome: Diane
Cognome: Taylor
Email: send email
Telefono: 441382000000

UK (DUNDEE) hostInstitution 1˙453˙180.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

fus    drug    theracav    ablation    strategies    tissue    ultrasound    monitoring    rapid    cavitation    series   

 Obiettivo del progetto (Objective)

'Focused Ultrasound Surgery (FUS) is rapidly emerging as a technique setting the gold-standard for the treatment of a wide range of diseases, including cancer. Current practise relies on the conversion of acoustic energy to thermal, for localised and minimally-invasive ablation with non-ionising radiation. Cavitation (the formation, and subsequent pressure driven dynamics, of bubbles) is a common occurrence at the high intensities typically employed for FUS. The extremely rapid, often violent evolution of cavitation in tissue exposed to focused ultrasound, poses a high risk of collateral damage to healthy tissue proximal to the site of pathology. TheraCav will demonstrate cavitation can be controlled and harnessed, to redefine the remit of FUS to include targeted drug delivery and rapid ablation formation via enhanced heating. Conceptually, cavitation could act to significantly permeabilise targeted tissue, rendering specific volumes highly susceptible to drug delivery through extravasation from the vasculature. Moreover, cavitation may actively pump and promote drug transport directly to the diseased tissue. If cavitation is to fulfil this potential, however, it is crucial that precise monitoring and control strategies are developed, demonstrating that it can be safely introduced and utilised tissue. Through a series of novel and ambitious objectives, TheraCav will develop techniques and devices to deliver this capability, calibrated against a recent innovation that has allowed the direct observation of cavitation at unprecedented spatial and temporal resolution. A series of translational work packages will test the monitoring and control strategies developed, in tissue-mimicking materials and ultimately soft-embalmed cadaver models, for anatomical verification. Finally, a radical and highly ambitious objective of activating photodynamic therapy drug compounds, via cavitation sonoluminescence and reactive oxygen species production, will be investigated.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

PLANT CIRES BIOTECH (2010)

Functional characterization of plant cellular IRES in response to abiotic stress and their use as biotechnological tools

Read More  

LATIN INTO HEBREW (2008)

Latin Philosophy into Hebrew: Intercultural Networks in 13th and 14th Century Europe

Read More  

COMFUS (2011)

Computational Methods for Fusion Technology

Read More