HYPERPOLARIZED MRI

Citicoline and deoxyglucose as new molecular imaging probes of DNP hyperpolarized MRI for cancer and neuroimaging

 Coordinatore HADASSAH MEDICAL ORGANIZATION 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Israel [IL]
 Totale costo 1˙650˙000 €
 EC contributo 1˙650˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-StG
 Funding Scheme ERC-SG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-11-01   -   2018-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    HADASSAH MEDICAL ORGANIZATION

 Organization address address: n/a
city: JERUSALEM
postcode: 91120

contact info
Titolo: Dr.
Nome: Hadas
Cognome: Lemberg
Email: send email
Telefono: +97 226776075

IL (JERUSALEM) hostInstitution 1˙650˙000.00
2    HADASSAH MEDICAL ORGANIZATION

 Organization address address: n/a
city: JERUSALEM
postcode: 91120

contact info
Titolo: Dr.
Nome: Rachel
Cognome: Katz-Brull
Email: send email
Telefono: +972 2 6777687
Fax: +972 2 6777687

IL (JERUSALEM) hostInstitution 1˙650˙000.00

Mappa


 Word cloud

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labeled    examinations    molecular    pet    tool    showing    clinical    modality    imaging    analogs    choline    isotope    pre    probes    deoxyglucose    mri    glucose    hyperpolarized    stable    radioactive    purpose    probe   

 Obiettivo del progetto (Objective)

'Radioactively labeled deoxyglucose and choline are the leading molecular imaging probes for positron emission tomography (PET). The clinical applications for this imaging modality include brain function, cardiac imaging, and inflammation, along with oncological applications which are taking the lead. The radiation exposure associated with these examinations is limiting the use of this powerful technology in repeated examinations, in specific populations (pregnant women and children), as a screening tool for the wide population, and as a clinical research tool. Hyperpolarized magnetic resonance imaging (MRI) is an evolving pre-clinical and clinical imaging modality which is non-invasive and non-radioactive. As in PET, the molecular imaging probe used is at the heart of this examination. Originally developed for the purpose of distinguishing the metabolic products of the injected molecular probe, our group, in collaborations with researchers abroad, is a pioneer in showing that direct imaging of specific molecular probes (stable isotope labeled choline and glucose analogs) with hyperpolarized MRI is capable of showing specific tissue uptake, a pre-requisite for diagnostic imaging. The purpose of the current proposal is to establish hyperpolarized MRI capabilities in our own lab and reach two general goals: 1) to use various physiological and pharmacological models to further establish and characterize the conditions in which non-radioactive choline and glucose analogs and derivatives can be useful as imaging probes; and 2) to investigate further the molecular probe that is best suitable for these imaging applications in terms of pharmacokinetics, metabolism, and imaging efficiency. Our focus will be on 1) the actual chemical entity of the probes - where citicoline and deoxyglucose are promising candidates; and 2) the stable isotope labeling strategy. The overriding goal is to aid in translation of this pre-clinical imaging approach to clinical use.'

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