DEVOCHROMO

Chromosome structure and genome organization in early mammalian development

 Coordinatore THE BABRAHAM INSTITUTE 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 2˙401˙392 €
 EC contributo 2˙401˙392 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-ADG
 Funding Scheme ERC-AG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-02-01   -   2019-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE BABRAHAM INSTITUTE

 Organization address address: Babraham Hall
city: CAMBRIDGE
postcode: CB22 3AT

contact info
Titolo: Mrs.
Nome: Kathryn
Cognome: Umande
Email: send email
Telefono: +44 1223 496590

UK (CAMBRIDGE) hostInstitution 2˙401˙393.00
2    THE BABRAHAM INSTITUTE

 Organization address address: Babraham Hall
city: CAMBRIDGE
postcode: CB22 3AT

contact info
Titolo: Prof.
Nome: Peter
Cognome: Fraser
Email: send email
Telefono: +44 1223 496644
Fax: +44 1223 496022

UK (CAMBRIDGE) hostInstitution 2˙401˙393.00

Mappa


 Word cloud

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genome    nuclear    functions    organization    chromosome    implantation    cell    epigenetic    dna    single    gene    pre    spatial   

 Obiettivo del progetto (Objective)

'The spatial organization of the genome inside the cell nucleus is tissue-specific and has been linked to several nuclear processes including gene activation, gene silencing, genomic imprinting, gene co-regulation, genome maintenance, DNA replication, DNA repair, chromosomal translocations and X chromosome inactivation. In fact, just about any nuclear/genome function has a spatial component that has been implicated in its control. We know surprisingly little about chromosome conformation and spatial organization or how they are established. The extent to which they are a cause or consequence of genome functions are current topics of considerable debate, however emerging data from my group and many other groups world-wide indicate that nuclear location and organization are drivers of genome functions, which in cooperation with other features including epigenetic marks, non-coding RNAs and trans-factor binding bring about genome control. Thus, genome spatial organization can be considered on a par with other epigenetic features that together contribute to overall genome control. The classical paradigm of early mammalian development arguably represents the most dramatic and yet least understood process of genome reprogramming, where a single cell undergoes a series of divisions to ultimately give rise to the hundreds of different cell types found in a mature organism. Study of pre-implantation embryo development is hindered by the very nature of the life form, composed of extremely low cell numbers at each stage, which severely limits the options for investigation. My lab has recently developed a novel technique called single cell Hi-C, which has the power to detect tens of thousands of simultaneous chromatin contacts from a single cell. In this application I propose to apply this technology to study chromosome structure and genome organization during mouse pre-implantation development along with single cell transcriptome analyses from the same cells.'

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