GUTTRYP

The role of the gut in experimental visceral leishmaniasis and Chagas disease

 Coordinatore LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE 

 Organization address address: KEPPEL STREET
city: LONDON
postcode: WC1E7HT

contact info
Titolo: Mr.
Nome: Andrews
Cognome: Chris
Email: send email
Telefono: +44 2079272486

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 294˙219 €
 EC contributo 294˙219 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IOF
 Funding Scheme MC-IOF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-10-01   -   2017-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

 Organization address address: KEPPEL STREET
city: LONDON
postcode: WC1E7HT

contact info
Titolo: Mr.
Nome: Andrews
Cognome: Chris
Email: send email
Telefono: +44 2079272486

UK (LONDON) coordinator 294˙219.60

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

host    interactions    persistence    cd    chronic    leishmaniasis    donovani    responses    gut    skin    commensal       site    immune    environment    vl    disease    cruzi    immunity    syndromes    parasite    infection   

 Obiettivo del progetto (Objective)

'Leishmania donovani and Trypanosoma cruzi cause the neglected infectious diseases visceral leishmaniasis (VL) and Chagas disease (CD) respectively. The host normally controls the initial wave of infection but rarely, if ever, fully clears the infection. Chronic, low-level infection then often progresses to serious clinical syndromes. Infection of a limited set of favoured tissues is a parasite strategy to evade host immunity and maintain chronicity. Recent work shows the gut is a site of chronic T. cruzi infection in CD mouse models. L. donovani persists in liver and spleen, but the gut may also be a target. In cutaneous leishmaniasis, chronic persistence occurs in the skin due to unique immune responses that evolved to tolerate constant exposure to the environment. A similar situation exists in the gut, where inflammatory responses against commensal microbe and food antigens are unwarranted and potentially dangerous. As in the skin, the hypo-responsive environment of the gut may underpin host failure to clear T. cruzi and L. donovani. Persistence in the gut may compromise microbiota containment leading to secondary syndromes (as in HIV and Toxoplasmosis) or exacerbate VL/CD pathology. Project objectives include (1) assessment of relevance of the gut as a site of L. donovani persistence (2) analysis of gut-specific responses to L. donovani (3) analysis of interactions between host, parasite and commensals and impact on gut immune homeostasis and disease (4) analysis of the gut-specific responses to T. cruzi that allow persistence. The training programme will develop a broad range of new technical and conceptual competencies to investigate general and gut-specific immunity and host-commensal interactions as well as enhanced transferable skills. This hypothesis-driven project has potential to reveal novel insights into the immunopathogenesis of VL and CD and should stimulate research on novel strategies to cure chronically infected patients.'

Altri progetti dello stesso programma (FP7-PEOPLE)

INNATELYBETTERCOWS (2013)

A genomics approach to increasing disease resistance in dairy cows through improvements in innate immunity

Read More  

T3D3 STEM CELLS (2011)

Thyroid hormone and development of cardiomyocytes derived from human embryonic and induced pluripotent stem cells

Read More  

MICROGLIA-EPILEPSY (2014)

Microglia phenotype in temporal lobe epilepsy

Read More