PSMS-IN-INFLAMMATION

Imaging Innate Immunity of Staphylococcal Infections

 Coordinatore  

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Nome: Susan
Cognome: Zwaagstra
Email: send email
Telefono: +31 88 7553017
Fax: +31 887555863

 Nazionalità Coordinatore Non specificata
 Totale costo 259˙582 €
 EC contributo 259˙582 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-04-09   -   2017-04-08

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Nome: Susan
Cognome: Zwaagstra
Email: send email
Telefono: +31 88 7553017
Fax: +31 887555863

NL (UTRECHT) coordinator 259˙582.50

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

psms    host    staphylococcal    small    infections    psm    neutrophil    ca    mrsa    virulence    infection    aureus    hdl    strains    functions    attract    complement    neutrophils    vivo   

 Obiettivo del progetto (Objective)

'Staphylococcus aureus community-acquired (CA)-MRSA strains are highly virulent and can cause infections in otherwise healthy individuals and are a leading cause of death worldwide. Innate immunity is our primary defense against invading staphylococci. Blood-neutrophils migrate to the site of infection where they, in concert with the complement system, engulf and kill bacteria in a process called phagocytosis. Especially CA-MRSA strains seem to be very efficient in circumventing this neutrophil killing. Interestingly, only a relative small number of virulence factors have been associated with CA-MRSA, one of which are the phenol soluble modulins (PSMs). In vivo models of experimental infection with PSM-mutants have shown a critical role for PSMs in skin and soft tissue infections. PSMs are small alpha-helical peptides which have two distinct functions on the immune system, in vitro PSMs can attract neutrophils in the nanomolar range, whereas in the micromolar range they are cytolytic for neutrophils. Recent publications suggests that these two functions complement each other for full staphylococcal virulence, although it seems counter-intuitive for S. aureus to actively attract its mortal enemy: the neutrophil. To make matters even more complicated PSMs are functionally inactivated by host serum lipoproteins, most efficiently by high density lipoprotein (HDL). The goal of this research proposal is to determine the mechanism of action for PSMs in staphylococcal disease. To this end, I will use genomic and proteomic approaches combined with cutting edge in vivo spinning-disk confocal microscopy, to dissect the functions of PSMs in host-staphylococcal interactions in; 1) neutrophil recruitment, 2) neutrophil lysis 3) HDL neutralization and liver pathology, 4) Evasion of PSM-recognition by FLIPR-L'

Altri progetti dello stesso programma (FP7-PEOPLE)

DISCO (2014)

A multidisciplinary Doctoral Industrial School on novel preventive strategies against E. Coli infections

Read More  

MUSC ADAP XRCS (2012)

Mechanisms of skeletal muscle adaptation to exercise and their implications in health and disease

Read More  

PHIL-RISK (2009)

Philosophy of Risk: An evaluative account of risk and safety and the methodological consequences for risk research

Read More