SUPRHAPOLYMERS

Engineering macromolecular self-assembly of hyaluronan (HA)-based glycopolymers with peptides

 Coordinatore QUEEN MARY UNIVERSITY OF LONDON 

 Organization address address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS

contact info
Titolo: Mr.
Nome: Greg
Cognome: Dow
Email: send email
Telefono: +44 20 7882 2569

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-03-01   -   2018-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON

 Organization address address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS

contact info
Titolo: Mr.
Nome: Greg
Cognome: Dow
Email: send email
Telefono: +44 20 7882 2569

UK (LONDON) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

synthetic    polymer    binding    glcua    supramolecular    glcnac    glycopolymers    peptide    structure    linear    containing    sugars    sequences    peptides    form   

 Obiettivo del progetto (Objective)

'Sugars and amino acids are natural building blocks which are used to form precisely regulated sequences in carbohydrates and proteins, respectively. While the field of proteomics has advanced immensely during the last past years, the field of glycomics is much less developed. The advance in synthetic polymer chemistry is allowing the possibility of controlling monomer sequences in synthetic macromolecules with diverse chemical structure providing many scientific and technological applications. “SuprHApolymers” project aims to design and synthesize glycopolymers mimicking the composition and structure of hyaluronan (HA), a linear polysaccharide composed of repeating disaccharide units of N-acetyl-glucosamine (GlcNAc) and glucuronic acid (GlcUA), but with many important biological functions. Linear glycopolymers, made solely of GlcNAc or GlcUA sugars (homopolymers) or containing both sugars (copolymers) will be synthesized to study their interaction with synthetic peptides bearing HA-binding motifs (peptide library). The synthesis of HA-based glycopopymers with branched architecture will be also attempted to explore different polymer configurations and to create optimal interactions with peptides. The self-assembly of HA glycopolymers with peptide amphiphiles containing selected HA-binding sequences will be investigated to form de novo peptide-polymer hybrid supramolecular materials with different molecular and macroscopic properties. Finally, the formed functional assemblies (nanostructures and supramolecular gels or films) will be explored for applications in synthetic biology and biomedicine.'

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