SEROTONIN IN ACTION

Serotonergic modulation of cortical activity in vivo: from neurons to networks and implications for autism spectrum disorders

 Coordinatore THE UNIVERSITY OF EDINBURGH 

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: +44 0131 650 3107
Fax: 441317000000

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 221˙606 €
 EC contributo 221˙606 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-06-01   -   2016-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: +44 0131 650 3107
Fax: 441317000000

UK (EDINBURGH) coordinator 221˙606.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

techniques    neuronal    determine    isolate    genetic    network    autism    spectrum    brain    imaging    cellular    cell    tools    dysfunction    ht    populations    action    visual    single    mechanisms    vivo    cortex    cortical    model    precise    nervous    fluoxetine    disorders   

 Obiettivo del progetto (Objective)

'Anti-depressant drugs such as fluoxetine (Prozac) increase levels of serotonin (5HT) in the brain, but little is known about how they affect the function of the nervous system. 5HT is implicated in a wide spectrum of brain functions and disorders. However, its precise role remains controversial and enigmatic. This is partly due to the previous inability to adequately isolate 5HT action in vivo. Recent developments in genetic tools and imaging techniques now offer an unprecedented opportunity to investigate such mechanisms in the living brain. This project aims to isolate 5HT transmission in the cerebral cortex and determine the precise cellular mechanisms underlying serotonergic neuromodulation of brain activity. Our objectives are to determine the action of 5HT in awake-behaving animals in three main ways: (1) on specific neuronal populations, at the network and single-cell level, by the local application of 5HT modulators (including fluoxetine); (2) when endogenously released, by controlling 5HT neuronal activity with optogenetic tools; and (3) on pathologic cortical network activity in an animal model of autism spectrum disorders. We will use the primary visual cortex as a model cortical area, investigating the role of 5HT in visually-evoked and activity-dependent cortical activation under normal conditions and during network dysfunction in autism spectrum disorders. In this project we will use state of the art in vivo two-photon calcium imaging and advanced genetic tools, including optogenetics. These cutting edge techniques will allow us to precisely activate 5HT neurons and measure the resulting effects on neuronal populations with single-cell resolution. The results will apply beyond the visual system to more broadly inform on cellular mechanisms of 5HT action in the central nervous system and its dysfunction in neurological disorders, leading to future advancements for therapeutic targeting.'

Altri progetti dello stesso programma (FP7-PEOPLE)

GLOREA (2008)

CENTRE FOR GLOBAL AND REGIONAL ETHNOGRAPHIES AT AARHUS UNIVERSITY

Read More  

EU CRIMINAL SECURITY (2010)

The Criminal Regulatory Network for Private Security Companies: European and International Perspectives

Read More  

EXMONAN (2014)

Experimental investigation and modelling of nanoscale solid state reactions with high technological impact

Read More